Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy DOI Creative Commons

Mengyao Yan,

Zhe Wang, Zhiwei Qiu

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 31, 2024

Platelets are essential for blood clotting and maintaining normal hemostasis. In pathological conditions, platelets increasingly recognized as crucial regulatory factors in various immune-mediated inflammatory diseases. Resting induced by such immune complexes through Fc receptors, platelet-targeting autoantibodies other platelet-activating stimuli. Platelet activation immunological processes involves the release of stimuli, antigen presentation interaction with cells. participate both innate system (neutrophils, monocytes/macrophages, dendritic cells (DCs) Natural Killer (NK) adaptive (T B cells). Clinical therapeutic strategies include targeting platelet activation, platelet-immune cell platelet-endothelial interaction, which display positive development prospects. Understanding mechanisms immunity is important, developing targeted modulations these will pave way promising strategies.

Language: Английский

The emerging role of neutrophil extracellular traps in autoimmune and autoinflammatory diseases DOI Creative Commons

Liuting Zeng,

Xiang Wang, Wei Xiao

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Neutrophil extracellular traps (NETs) are unique fibrous structures released by neutrophils in response to various pathogens, exhibiting both anti-inflammatory and proinflammatory effects. In autoimmune conditions, NETs serve as crucial self-antigens triggering inflammatory cascades activating the inflammasome complement systems, disrupting self-tolerance mechanisms accelerating responses. Furthermore, play a pivotal role modulating immune cell activation, affecting adaptive This review outlines intricate relationship between diseases, including arthritis, systemic Behçet's disease, lupus erythematosus, kidney skin sclerosis, vasculitis, gouty arthritis. It highlights potential of targeting therapeutic strategy diseases. By examining dynamic balance NET formation clearance this offers critical insights theoretical foundation for future research on NET-related mechanisms. Advances systems biology, flow cytometry, single-cell multiomics sequencing have provided valuable tools exploring molecular NETs. These advancements renewed focus offering promising avenues further investigation into their clinical implications.

Language: Английский

Citations

0
Extracellular vesicles lay the ground for neuronal plasticity by restoring mitochondrial function, cell metabolism and immune balance DOI
Dirk M. Hermann, Chen Wang, Ayan Mohamud Yusuf

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Extracellular vesicles (EVs) convey complex signals between cells that can be used to promote neuronal plasticity and neurological recovery in brain disease models. These EV are multimodal context-dependent, making them unique therapeutic principles. This review analyzes how EVs released from various cell sources control metabolic function, survival plasticity. Preferential sites of communication the interfaces pre- postsynaptic neurons at synapses, astrocytes plasma membranes or tripartite oligodendrocytes axons, microglial cells/macrophages neurons, cerebral microvascular neurons. At each these interfaces, support mitochondrial function metabolism under physiological conditions orchestrate response injury. In injured brain, promotion by is tightly linked with actions on metabolism, oxidative stress immune responses. Via stabilization balance, responses activated functional induced. As such, lay ground for

Language: Английский

Citations

0
Neutrophil extracellular traps (NETs) and NETosis in alcohol‐associated diseases: A systematic review DOI Open Access

Mohammed A. S. Khan,

Byoung‐Joon Song, Xin Wang

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract Heavy alcohol consumption is implicated in the alteration of antimicrobial function neutrophils, such as phagocytosis, chemotaxis, formation neutrophil extracellular traps (NETs), and occurrence NETosis. NETosis an endogenous process elimination invading microbes, autoantibodies, inflammatory elements danger‐associated molecular patterns (DAMPs) pathogen‐associated (PAMPs). However, both exaggeration suppression modulate normal physiological metabolic processes by influencing events at cellular levels. Recent research shows that binge induces NETosis, leading to tissue damage inflammation. Binge consumption, chronic intake, use disorder (AUD) can affect immunity often lead alcohol‐associated liver disease (ALD) and/or other organ damage. Alcohol detrimental consequences multiple organs, including brain, liver, pancreas, gut. Gut‐derived microbial substances, endotoxins circulation, induce systemic Sterile danger signals from damaged cells, cytokines, prostaglandins act proinflammatory stimuli are involved signaling pathways. The alcohol‐induced cytokines chemoattract which interact coordinate with immune cells exaggerate or suppress inflammation within milieu, depending on effects. Several proteins, different receptors, play important roles activation NETs well initiation execution This review article specifically gathers current information its biological components, pathways relating associated ALD AUD multiorgans, We also briefly describe various therapeutic strategies against AUD‐associated experimental models human states.

Language: Английский

Citations

0
Bacterial meningitis is a significant catalyst for neuroinflammation DOI
Sudharsan Parthasarathy, Siva Vijayakumar Tharumasivam,

Ashajyothi Chavaan

et al.

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Infection route influence the consequences of Nocardia farcinica infection in BALB/c mice DOI Creative Commons
Jirao Shen, Lichao Han,

Jiang Yao

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 20, 2024

Nocardia, a rare but potentially fatal pathogen, can induce systemic infections with diverse manifestations. This study aimed to investigate the tissue and organ damage caused by Nocardia farcinica (N. farcinica) in mice via different infection routes, evaluate resulting host immune responses, assess its invasiveness brain tissue.

Language: Английский

Citations

2
Unveiling the covert interaction between gut microbiota and neutrophils to drive colorectal cancer metastasis DOI

Peiliang Shen,

Peng Cheng, Yanan Li

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 962, P. 176217 - 176217

Published: Nov. 28, 2023

Language: Английский

Citations

6
Neutrophil extracellular traps as a unique target in the treatment of inflammatory pain DOI

Wanxiang Qin,

Yuping Li, Jian Cui

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 710, P. 149896 - 149896

Published: April 5, 2024

Language: Английский

Citations

1
Monitoring of Perioperative Microcirculation Dysfunction by Near-Infrared Spectroscopy for Neurological Deterioration and Prognosis of Aneurysmal Subarachnoid Hemorrhage: An Observational, Longitudinal Cohort Study DOI Creative Commons

Shunyan Yang,

Binbin Tan, Jie Lin

et al.

Neurology and Therapy, Journal Year: 2024, Volume and Issue: 13(2), P. 475 - 495

Published: Feb. 17, 2024

No evidence has established a direct causal relationship between early microcirculation disturbance after aneurysmal subarachnoid hemorrhage (aSAH) and neurological function prognosis, which is the key pathophysiological mechanism of brain injury (EBI) in patients with aSAH. A total 252 aSAH were enrolled Neurosurgical Intensive Care Unit Southwest Hospital January 2020 December 2022 divided into no deterioration, delayed deterioration groups. Indicators disorders EBI included regional cerebral oxygen saturation (rSO2) measured by near-infrared spectroscopy (NIRS), monitoring, other clinical parameters for evaluating determining prognosis Our data suggest that rSO2 generally lower who develop than those do not there at least one time point population where left right hemisphere differences can be significantly monitored NIRS. An unordered multiple-classification logistic regression model was constructed, results revealed multiple factors effective predictors deterioration: reoperation, history surgery, World Federation Societies (WFNS) grade 4-5, Fisher 3-4, SAFIRE 3-5, abnormal serum sodium potassium levels, reduced during perioperative period. However, aSAH, only surgery RBC count predictive indicators. The concentration without via further studies are needed to determine role neurocritical management as these reduce incidence adverse outcomes mortality hospitalization.

Language: Английский

Citations

0
Associations of three differential white blood cell counts, platelet counts, and their derived inflammatory indices with cancer-related fatigue in patients with breast cancer undergoing chemotherapy DOI
Guopeng Li, Di Zhao, Rui Qin

et al.

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(7)

Published: July 1, 2024

Language: Английский

Citations

0
Erythrocyte Osmotic Fragility as a Diagnostic Marker in Glaucoma: A Comprehensive Analysis Using LASSO Regression DOI
Jialiang Yang,

Fang Yang,

Junming Gu

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Objective This study investigates the potential of blood biomarkers in early diagnosis glaucoma, focusing on erythrocyte osmotic fragility (EOF) as a novel indicator. We used Least Absolute Shrinkage and Selection Operator (LASSO) regression to evaluate EOF’s predictive utility for glaucoma diagnosis. Methods included 195 confirmed patients an equal number age- sex-matched healthy controls. Blood samples were analyzed various parameters, including white cell count, neutrophil red (RBC) EOF. Key differential markers identified, model was constructed using LASSO models. Results analysis identified HCT, NEUT, LYMPH, MCV, MCHC, EOF critical discriminating from Incorporating into significantly enhanced its performance, with showing positive correlation likelihood glaucoma. Conclusions is promising biomarker Combining other improves accuracy

Language: Английский

Citations

0