GeroScience, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
Language: Английский
Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(11), P. 2138 - 2151
Published: Sept. 18, 2024
Language: Английский
Citations
13
Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: July 8, 2024
Abstract Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance (MRI) biomarker for investigating brain function and composition. This comprehensive review synthesizes the current state of knowledge on MWF human cerebral aging, neurodegenerative diseases, risk factors influencing myelination. The databases used include Web Science, Scopus, Science Direct, PubMed. We begin with brief discussion theoretical foundations imaging, including its basis in MR physics mathematical modeling underlying calculation, an overview most adopted MRI methods imaging. Next, we delve into clinical research applications that have been explored to date, highlighting advantages limitations. Finally, explore potential serve predictive neurological disorders identify future directions optimizing protocols interpreting various contexts. By harnessing power may gain new insights health disease across lifespan, ultimately informing novel diagnostic therapeutic strategies. image
Language: Английский
Citations
8
Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122952 - 122952
Published: Aug. 9, 2024
The bidirectional regulation between the gut microbiota and brain, known as gut-brain axis, has received significant attention. myelin sheath, produced by oligodendrocytes or Schwann cells, is essential for efficient nervous signal transmission maintenance of brain function. Growing evidence shows that both oligodendrogenesis myelination are modulated its metabolites, when dysbiosis occurs, changes in composition and/or associated metabolites may impact developmental occurrence neurodevelopmental disabilities. Although link demyelinating disease such multiple sclerosis been extensively studied, our knowledge about role other myelin-related disorders, neurodegenerative diseases, limited. Mechanistically, microbiota-oligodendrocyte axis primarily mediated factors inflammation, vagus nerve, endocrine hormones, evidenced metagenomics, metabolomics, vagotomy, morphological molecular approaches. Treatments targeting this include probiotics, prebiotics, microbial herbal bioactive compounds, specific dietary management. In addition to commonly used approaches, viral vector-mediated tracing gene manipulation, integrated multiomics multicenter clinical trials will greatly promote mechanistic interventional studies ultimately, development new preventive therapeutic strategies against gut-oligodendrocyte axis-mediated impairments. Interestingly, recent findings showed can be induced hippocampal damage reversible myelin-targeted drugs, which provides insights into understanding how hippocampus-based functional impairment (such Alzheimer's disease) regulates peripheral homeostasis systemic disorders.
Language: Английский
Citations
4
Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(1)
Published: Jan. 1, 2025
ABSTRACT Parkinson's disease (PD) is a prevalent neurodegenerative caused by the death of dopaminergic neurons within substantia nigra pars compacta (SNpc) region midbrain. Recent genomic and single cell sequencing data identified oligodendrocytes oligodendrocyte precursor cells (OPCs) to confer genetic risk in PD, but their biological role unknown. Although SNpc are scarcely or thinly myelinated, there gap knowledge concerning physiological interactions between oligodendroglia. We sought investigate distribution OPCs with regard myelination state mouse (SN) high‐resolution imaging provide morphological assessment OPC‐dopaminergic neuron quantification numbers across different age groups. evenly distributed midbrain throughout lifespan they physically interact both soma axons neurons. The presence interaction does not correlate myelin. Myelination sparse SNpc, including fibers originating from projecting through reticulata (SNpr). report that exist 1:1 ratio accounting for 15%–16% all This description provides first look at longitudinal mice, suggesting additional functions beyond differentiation into myelinating oligodendrocytes. image
Language: Английский
Citations
0
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106827 - 106827
Published: Feb. 1, 2025
Spinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited and belongs to family of nine diseases caused by a polyglutamine expansion in disease-causing protein. In SCA3, ATXN3 causes neuron loss disease-vulnerable brain regions, resulting progressive coordination ultimately death. There are no disease-modifying or preventative treatments for this uniformly fatal disorder. Recent studies demonstrate prominent white matter atrophy microstructural alterations regions SCA3 patients mouse models. However, major constituent - lipids remains understudied SCA3. study, we conducted first unbiased investigation focusing on cerebellum postmortem Liquid chromatography-mass spectrometry uncovered widespread lipid reductions with Lipid downregulation was recapitulated early- mid-stage models including transgenic YACQ84 Knock-in Q300 mice. End-stage mice displayed reduction content, highlighting targets that could benefit from early therapeutic intervention. contrast, Atxn3-Knock-out showed mild upregulation, emphasizing toxic gain-of-function mechanism underlying We conclude significantly altered establish platform continued exploration disease through interactive data visualization websites. Pronounced myelin-enriched suggest dysregulation underlie This study establishes basis future work elucidating mechanistic, biomarker, potential
Language: Английский
Citations
0
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 207, P. 106816 - 106816
Published: Feb. 6, 2025
Spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder caused by excess CAG repeats in the ATXN3 gene, leads to progressive cerebellar and other symptoms. The results of previous studies suggest that trace element dysregulation contributes onset. Here, we investigated relationships with repeat length, clinical severity, brain structural functional connectivity 45 patients SCA3 44 healthy controls (HCs). Blood levels lithium (Li), selenium (Se), copper (Cu) were significantly lower than HCs; Li Se negatively correlated especially manifest subgroup. Diffusion tensor imaging combined resting-state magnetic resonance revealed fractional anisotropy white matter (WM) bilateral frontal parietal regions; tractography mapping showed Li-associated region nerve fiber pathways SCA3. Dynamic causal modeling analyses bidirectional from inferior lobule(IPL) cerebellum was blood level Time series correlation-based analysis intrinsic connectivities dorsal premotor cortex(PMd) IPL local regions weaker HCs. Our dysregulation, deficiency, induces alterations manifestations SCA3; supplementation may be beneficial for WM or astrocytes this patient population.
Language: Английский
Citations
0
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102697 - 102697
Published: Feb. 1, 2025
Language: Английский
Citations
0
Glia, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Chronic neuroinflammation, driven by central nervous system (CNS)-resident astrocytes and microglia, as well infiltration of the peripheral immune system, is an important pathologic mechanism across a range neurologic diseases. For decades, research focused almost exclusively on how neuroinflammation impacted neuronal function; however, there accumulating evidence that injury to oligodendrocyte lineage component for both clinical outcomes. While oligodendrocytes are able undergo endogenous repair process known remyelination, this becomes inefficient usually fails in presence sustained inflammation. The present review focuses our current knowledge regarding activation innate adaptive systems chronic demyelinating disease, multiple sclerosis, provides other conditions, such perinatal white matter injury, traumatic brain viral infections, converges injury. Lastly, therapeutic potential targeting impact inflammation these diseases discussed.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113631 - 113631
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0