Redox Biology,
Journal Year:
2023,
Volume and Issue:
62, P. 102677 - 102677
Published: March 17, 2023
Ferroptosis,
an
iron-dependent
lipid
peroxidation-driven
programmed
cell
death,
is
closely
related
to
cancer
therapy.
The
development
of
druggable
ferroptosis
inducers
and
their
rational
application
in
therapy
are
critical.
Here,
we
identified
Tubastatin
A,
HDAC6
inhibitor
as
a
novel
inducer
through
large-scale
drug
screening.
A
directly
bonded
GPX4
inhibited
enzymatic
activity
biotin-linked
putdown
LC/MS
analysis,
which
independent
its
inhibition
HDAC6.
In
addition,
our
results
showed
that
radiotherapy
not
only
activated
Nrf2-mediated
transcription
but
also
lysosome-mediated
degradation,
subsequently
inducing
tolerance
radioresistance
cells.
overcame
resistance
cells
by
inhibiting
activity.
More
importantly,
has
excellent
bioavailability,
demonstrated
ability
significantly
promote
radiotherapy-induced
peroxidation
tumour
suppression
mouse
xenograft
model.
Our
findings
identify
inducer,
enhances
radiotherapy-mediated
antitumor
effects.
This
work
provides
compelling
rationale
for
the
clinical
evaluation
especially
combination
with
radiotherapy.
Theranostics,
Journal Year:
2022,
Volume and Issue:
13(2), P. 483 - 509
Published: Dec. 19, 2022
Computed
tomography
(CT),
a
diagnostic
tool
with
clinical
application,
comprehensive
coverage,
and
low
cost,
is
used
in
hospitals
worldwide.
However,
CT
imaging
fails
to
distinguish
soft
tissues
from
normal
organs
tumors
because
their
mass
attenuation
coefficients
are
similar.
Various
contrast
agents
have
been
developed
recent
years
improve
the
sensitivity
of
imaging.
Here,
we
review
progress
nanomaterial-based
applications
image-guided
therapy.
The
classified
according
components;
gold
(Au)-based,
bismuth
(Bi)-based,
lanthanide
(Ln)-based,
transition
metal
(TM)-based
nanomaterials
discussed.
therapy
diseases,
including
photothermal
(PPT),
photodynamic
(PDT),
chemotherapy,
radiotherapy
(RT),
gas
therapy,
sonodynamic
(SDT),
immunotherapy,
starvation
gene
(GT),
microwave
thermal
(MWTT),
reviewed.
Finally,
perspectives
on
biomedical
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(3), P. 704 - 704
Published: March 12, 2023
Nutrition
has
a
significant
effect
and
crucial
role
in
disease
prevention.
Low
consumption
of
fruit
vegetables
sedentary
lifestyle
are
closely
related
with
the
onset
development
many
types
cancer.
Recently,
nutraceuticals
have
gained
much
attention
cancer
research
due
to
their
pleiotropic
effects
relatively
non-toxic
behavior.
In
fact,
although
past
there
been
conflicting
results
on
some
antioxidant
compounds
as
allies
against
cancer,
numerous
recent
clinical
studies
highlight
efficacy
dietary
phytochemicals
prevention
treatment
However,
further
investigation
is
necessary
gain
deeper
understanding
potential
anticancer
capacities
well
mechanisms
action.
Therefore,
this
review
examined
current
literature
key
properties
bioactive
components
present
diet,
such
carotenoids,
polyphenols,
compounds,
use
therapy.
The
focused
chemopreventive
properties,
evaluating
synergistic
drugs
and,
consequently,
side
associated
treatments.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 860 - 860
Published: April 2, 2023
It
is
more
effective
to
maintain
good
health
than
regain
it
after
losing
it.
This
work
focuses
on
the
biochemical
defense
mechanisms
against
free
radicals
and
their
role
in
building
maintaining
antioxidant
shields,
aiming
show
how
balance,
as
much
possible,
situations
which
we
are
exposed
radicals.
To
achieve
this
aim,
foods,
fruits,
marine
algae
with
a
high
content
should
constitute
basis
of
nutritional
elements,
since
natural
products
known
have
significantly
greater
assimilation
efficiency.
review
also
gives
perspective
use
antioxidants
can
extend
life
food
products,
by
protecting
them
from
damage
caused
oxidation
well
additives.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
62, P. 102677 - 102677
Published: March 17, 2023
Ferroptosis,
an
iron-dependent
lipid
peroxidation-driven
programmed
cell
death,
is
closely
related
to
cancer
therapy.
The
development
of
druggable
ferroptosis
inducers
and
their
rational
application
in
therapy
are
critical.
Here,
we
identified
Tubastatin
A,
HDAC6
inhibitor
as
a
novel
inducer
through
large-scale
drug
screening.
A
directly
bonded
GPX4
inhibited
enzymatic
activity
biotin-linked
putdown
LC/MS
analysis,
which
independent
its
inhibition
HDAC6.
In
addition,
our
results
showed
that
radiotherapy
not
only
activated
Nrf2-mediated
transcription
but
also
lysosome-mediated
degradation,
subsequently
inducing
tolerance
radioresistance
cells.
overcame
resistance
cells
by
inhibiting
activity.
More
importantly,
has
excellent
bioavailability,
demonstrated
ability
significantly
promote
radiotherapy-induced
peroxidation
tumour
suppression
mouse
xenograft
model.
Our
findings
identify
inducer,
enhances
radiotherapy-mediated
antitumor
effects.
This
work
provides
compelling
rationale
for
the
clinical
evaluation
especially
combination
with
radiotherapy.
