Synthesis, Structure, and Stability of Copper(II) Complexes Containing Imidazoline-Phthalazine Ligands with Potential Anticancer Activity DOI Creative Commons
Łukasz Balewski, Iwona Inkielewicz‐Stępniak, М. Gdaniec

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 375 - 375

Published: March 6, 2025

Background/Objectives: Recently, there has been great interest in metallopharmaceuticals as potential anticancer agents. In this context, presented studies aim to synthesize and evaluate of two copper(II) complexes derived from phthalazine- imidazoline-based ligands against on three human cancer cell lines: cervix epithelial line (HeLa), breast epithelial-like adenocarcinoma (MCF-7), triple–negative (MDA-MB-231), well non-tumorigenic (HDFa). Moreover their antimicrobial, antioxidant properties were assessed. Methods: The synthetized compounds—both free L1, L2, L3 C1 C2—were characterized by elemental analysis, infrared spectroscopy. Additionally, a single-crystal X-ray diffraction we performed for ligand its complex C2. stability Cu(II)-complexes C2 was evaluated UV-Vis cytotoxic potency estimated HeLa, MCF-7, MDA-MB-231, non-cancerous HDFa use an MTT assay after 48 h incubation. Moreover, the antimicrobial activity L1 using reference strains following bacteria yeasts: Staphylococcus aureus, Escherichia coli, Candida albicans. radical scavenging corresponding C1, tested with colorimetric methods—ABTS, DPPH, reduction ability (FRAP). ADME webtool used assess drug-likeness synthesized compounds, physicochemical pharmacokinetic properties. Results: Copper(II) exhibited antitumor towards MDA-MB-231 compared Cisplatin (cancer viability rate 23.6% vs. 22.5%). At concentration 200 μg/mL, less than normal, skin fibroblast According vitro tests, reduced cells about 57.5–81.2%. It evident that all compounds devoid antibacterial or antifungal activity. assays revealed moderate antiradical effect observed containing phthalazin-1(2H)-imine ABTS (IC50 = 23.63 µg/mL). Conclusions: most potent compound bearing phthalazin-1(2H)-one scaffold. None showed This feature seems be beneficial terms uses agents future. only phthalazin-1(2H)-imine.

Language: Английский

Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer DOI Open Access
Pasquale Marino,

Mariangela Mininni,

Giovanni Deiana

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 800 - 800

Published: March 11, 2024

Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence increased over years. A potential strategy to counter growing spread various forms cancer is adoption prevention strategies, in particular, use healthy lifestyles, such maintaining weight, following diet; being physically active; avoiding smoking, alcohol consumption, sun exposure; vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing development, progression, severity. This review evaluates relationship between potentially overall specifically breast, colorectal, prostate cancer, highlights updated recommendations on prevention. The results numerous clinical epidemiological studies clearly show influence lifestyles development cancer. An incorrect diet, composed mainly saturated fats processed products, resulting body combined physical inactivity, induced an increase all three types under study. Given importance adopting correct prevent global institutions should develop strategies environments that encourage individuals adopt regular behaviors.

Language: Английский

Citations

68
Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health DOI
Yasser Fakri Mustafa

Indian Journal of Clinical Biochemistry, Journal Year: 2023, Volume and Issue: 39(2), P. 154 - 167

Published: Aug. 1, 2023

Language: Английский

Citations

54
Latest advances in hepatocellular carcinoma management and prevention through advanced technologies DOI Creative Commons

Tamer A. Addissouky,

Ibrahim El Tantawy El Sayed, Majeed M. A. Ali

et al.

Egyptian Liver Journal, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 2, 2024

Abstract Background Hepatocellular carcinoma (HCC) is a common type of liver cancer, with high mortality rate. cancer that can be effectively managed through early detection and accurate diagnosis, followed by personalized treatment plan may include surgical resection, transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending on the stage severity cancer. Main body abstract This paper discusses recent advances in detection, management, prevention HCC. The use newer imaging such as Magnetic resonance (MRI) contrast-enhanced ultrasound, along image segmentation technology deep learning models, have greatly enhanced accuracy HCC diagnosis. Minimally-invasive thermal ablation radiofrequency ablation, allowed for more precise destruction tumors, while Nanoparticles, immunotherapy shown promise management advanced Artificial intelligence (AI) machine has revolutionized research, aiding identification high-risk patients predicting outcomes. Lifestyle modifications, weight alcohol avoidance, hepatitis B vaccinations, play critical role preventing development. Short conclusion Recent improving patient therapy, AI research lifestyle modifications prevention. However, further required to fully understand potential benefits nanoparticles, traditional Chinese medicine herbal medicines treatment. Graphical

Language: Английский

Citations

35
Oxidative Stress and Age-Related Tumors DOI Creative Commons
Emma Di Carlo, Carlo Sorrentino

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1109 - 1109

Published: Sept. 13, 2024

Oxidative stress is the result of imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous exogenous processes, antioxidant defenses consisting molecules that protect biological systems from free radical toxicity. a major factor in aging process, contributing to accumulation cellular damage over time. biomolecules, leads DNA alterations, lipid peroxidation, protein oxidation, mitochondrial dysfunction resulting senescence, immune system tissue dysfunctions, increased susceptibility age-related pathologies, such as inflammatory disorders, cardiovascular neurodegenerative diseases, diabetes, cancer. stress-driven mutations, or methylation histone modification, alter gene expression, key determinants tumor initiation, angiogenesis, metastasis, therapy resistance. Accumulation genetic epigenetic damage, oxidative contributes, eventually unrestrained cell proliferation, inhibition differentiation, evasion death, providing favorable conditions for tumorigenesis. Colorectal, breast, lung, prostate, skin cancers most frequent aging-associated malignancies, implicated their pathogenesis behavior. Our aim shed light on molecular mechanisms link stress, aging, cancers, highlighting impact both RONS antioxidants, provided diet exercise, immunity, development an antitumor response. The dual role ROS physiological regulators signaling responsible well its use anti-tumor therapeutic purposes, will also be discussed. Managing crucial promoting healthy reducing risk tumors.

Language: Английский

Citations

17
Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of In Vitro and In Vivo Potential DOI Creative Commons
Maria Rosaria Miranda, Vincenzo Vestuto, Giuseppina Amodio

et al.

Life, Journal Year: 2024, Volume and Issue: 14(3), P. 420 - 420

Published: March 21, 2024

Lycium barbarum, known as goji berry or wolfberry, is a fruit long associated with health benefits, showing plethora of effects ranging from antioxidant, anticancer, anti-inflammatory, and immunomodulatory effects. Its potential attributed to the significant presence polysaccharides, glycopeptides, polyphenols, flavonoids, carotenoids, their derivatives. These compounds effectively counteract action free radicals, positively influencing cellular balance intracellular signaling, contributing overall cell function acting on multiple molecular pathways. Several fractions extracted berries demonstrate antitumor properties, particularly effective against breast cancer, without cytotoxic normal human cells. Hence, review explored fundamental traits bioactive elements in barbarum cancer treatment and, specifically, cancer. It focused elucidating wolfberry’s influenced biochemical pathways, its synergism anticancer drugs, alleviate side existing treatments.

Language: Английский

Citations

14
Bioactivity and Bioavailability of Carotenoids Applied in Human Health: Technological Advances and Innovation DOI Open Access
Tomás Gabriel Bas

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7603 - 7603

Published: July 11, 2024

This article presents a groundbreaking perspective on carotenoids, focusing their innovative applications and transformative potential in human health medicine. Research jointly delves deeper into the bioactivity bioavailability of revealing therapeutic uses technological advances that have to revolutionize medical treatments. We explore pioneering which carotenoids are used treat chronic diseases such as cancer, cardiovascular disease, age-related macular degeneration, offering novel protective mechanisms benefits. Our study also shows cutting-edge innovations carotenoid extraction bioavailability, including development supramolecular carriers advanced nanotechnology, dramatically improve absorption efficacy these compounds. These not only ensure consistent quality but tailor therapies each patient's needs, paving way for personalized By integrating latest scientific discoveries techniques, this research provides prospective clinical establishing new benchmark future studies field. findings underscore importance optimizing extraction, administration, bioactivity, methods develop more effective, targeted, treatments, thus visionary insight modern practices.

Language: Английский

Citations

12
A review on the composition, extraction and applications of phenolic compounds DOI
Great Iruoghene Edo, Susan Chinedu Nwachukwu,

Ali B.M. Ali

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

12
Catechin and quercitrin mitigate the cytotoxic effects of aflatoxin-B1 on liver and colon cells by inhibiting cytochrome P450 1A2 and 3A4, in silico DOI
Solomon Abrehame Tsega, Valsa Remony Manoj, Merry Hailu Gebretsadik

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105989 - 105989

Published: Jan. 1, 2025

Language: Английский

Citations

1
Much More than Nutrients: The Protective Effects of Nutraceuticals on the Blood–Brain Barrier in Diseases DOI Open Access

Anna E. Kocsis,

Nóra Kucsápszky,

Ana Raquel Santa-Maria

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 766 - 766

Published: Feb. 21, 2025

The dysfunction of the blood-brain barrier (BBB) is well described in several diseases, and considered a pathological factor many neurological disorders. This review summarizes most important groups natural compounds, including alkaloids, flavonoids, anthocyanidines, carotenoids, lipids, vitamins that were investigated for their potential protective effects on brain endothelium. penetration these compounds interaction with BBB efflux transporters solute carriers are discussed. cerebrovascular endothelium therapeutic target diseases. In preclinical studies modeling systemic central nervous system nutraceuticals exerted beneficial BBB. vivo, they decreased permeability, edema, astrocyte swelling, morphological changes vessel structure basal lamina. At level endothelial cells, increased cell survival apoptosis. From general functions, angiogenesis levels vasodilating agents demonstrated. elevated integrity by tightened intercellular junctions, expression activity transporters, such as pumps, carriers, metabolic enzymes, shown. Nutraceuticals enhanced antioxidative defense anti-inflammatory at signaling mediating stability activation WNT, PI3K-AKT, NRF2 pathways, inhibition MAPK, JNK, ERK, NF-κB pathways. represent valuable source new potentially molecules to treat diseases protecting

Language: Английский

Citations

1
Antitumor Assessment of Liposomal Beta-Carotene with Tamoxifen Against Breast Carcinoma Cell Line: An In Vitro Study DOI Creative Commons
Mohamed Elsayed, Medhat W. Shafaa, Mohga S. Abdalla

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 486 - 486

Published: March 26, 2025

The present study was designed to characterize the interactions between lecithin liposomes, a model membrane, and either β-carotene or tamoxifen. In addition, cytotoxicity of liposomal beta-carotene with tamoxifen screened in vitro human breast cancer cell lines MCF-7 MDA-MB-231 addition normal WI38 line. All liposomes were nearly spherical evenly distributed had fewer aggregates for encapsulated empty vesicles. Measurements using dynamic light scattering verified that each sample monodisperse. When is incorporated into membranes, zeta potential values tend decrease. test treated cells, IC50 value at least 0.45 μg/mL, whereas free cells 7.8 μg/mL. For tamoxifen, 9.92 but its form, it 20.88 According β-carotene, 15.5 38.1 12.1 21.2 11.4 respectively. This investigation demonstrated has more potent cytotoxic impact than findings showed comet assay variable significantly (p < 0.05) elevated comparison control values. Analysis flow cytometry revealed displayed greater degree apoptosis following 48 h exposure β-carotene. Based on available data, novel treatment plan includes may boost antitumor activity toward current preparations natural products might be good substitute pharmaceutical interventions cancer.

Language: Английский

Citations

1