Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(8), P. 1114 - 1114

Published: July 21, 2021

For the last 40 years, praziquantel has been standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide. However, there is no suitable paediatric formulation on market, leading to off-label use and splitting of commercial tablets adults. In this study, we recently available technology, direct powder extrusion (DPE) three-dimensional printing (3DP), prepare Printlets™ (3D printed tablets) amorphous solid dispersions with Kollidon® VA 64 surfactants (Span™ 20 or Kolliphor® SLS). Printlets were successfully from both pellets powders obtained extrudates by hot melt (HME). vitro dissolution studies showed greater four-fold increase in release, due formation dispersions. palatability data indicated that printlets range tolerability, highlighting taste masking capabilities technology without need additional excipients. This work demonstrated possibility 3D using forms HME, avoiding filaments fused deposition modelling 3DP. Moreover, main hurdles praziquantel, such as low drug solubility, inadequate taste, high variable dose requirements, can be overcome technology.

Language: Английский

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State-of-the-Art Review of Artificial Neural Networks to Predict, Characterize and Optimize Pharmaceutical Formulation

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(1), P. 183 - 183

Published: Jan. 13, 2022

During the development of a pharmaceutical formulation, powerful tool is needed to extract key points from complicated process parameters and material attributes. Artificial neural networks (ANNs), promising more flexible modeling technique, can address real intricate questions in high parallelism distributed pattern manner biological networks. The data mined analyzing based on ANNs have ability replace hundreds trial error experiments. been used for analysis by pharmaceutics researchers since 1990s it has now become research method science. This review focuses latest application progress prediction, characterization optimization formulation provide reference further interdisciplinary study ANNs.

Language: Английский

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A Review of State-of-the-Art on Enabling Additive Manufacturing Processes for Precision Medicine

Journal of Manufacturing Science and Engineering, Journal Year: 2022, Volume and Issue: 145(1)

Published: Nov. 8, 2022

Abstract Precision medicine is an emerging healthcare delivery approach that considers variability between patients, such as genetic makeups, in contrast to the current one-size-fits-all designed treat average patient. The White House launched Medicine Initiative 2015, starting endeavor reshape delivery. To translate concept of precision from bench practice, advanced manufacturing will play integral part, including fabrication personalized drugs and drug devices screening platforms. These products are highly customized require robust yet flexible systems. field has rapidly evolved past five years. In this state-of-the-art review, manufactured for be introduced, followed by a brief review processing materials their characteristics. A on different processes applicable those aforementioned provided. status development regulatory submission quality control considerations also discussed. Finally, paper presents future outlook used medicine.

Language: Английский

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Energy consumption and carbon footprint of 3D printing in pharmaceutical manufacture

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 639, P. 122926 - 122926

Published: April 7, 2023

Achieving carbon neutrality is seen as an important goal in order to mitigate the effects of climate change, dioxide a major greenhouse gas that contributes global warming. Many countries, cities and organizations have set targets become neutral. The pharmaceutical sector no exception, being contributor emissions (emitting approximately 55% more than automotive for instance) hence need strategies reduce its environmental impact. Three-dimensional (3D) printing advanced fabrication technology has potential replace traditional manufacturing tools. Being new technology, impact 3D printed medicines not been investigated, which barrier uptake by industry. Here, energy consumption (and emission) printers considered, focusing on technologies successfully demonstrated produce solid dosage forms. 6 benchtop was measured during standby mode printing. On standby, ranged from 0.03 0.17 kWh. required producing 10 printlets 0.06 3.08 kWh, with using high temperatures consuming energy. Carbon between 11.60 112.16 g CO2 (eq) per printlets, comparable tableting. Further analyses revealed decreasing temperature found demand considerably, suggesting developing formulations are printable at lower can emissions. study delivers key initial insights into potentially transformative provides encouraging results demonstrating deliver quality without environmentally detrimental.

Language: Английский

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3D printing technology: A new approach for the fabrication of personalized and customized pharmaceuticals

European Polymer Journal, Journal Year: 2023, Volume and Issue: 195, P. 112240 - 112240

Published: June 20, 2023

Language: Английский

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