iScience,
Journal Year:
2024,
Volume and Issue:
27(2), P. 108873 - 108873
Published: Jan. 11, 2024
Lung
adenocarcinoma
(LUAD)
is
one
of
the
leading
causes
cancer-related
death
worldwide.
Epithelial-mesenchymal
transition
(EMT)
plays
an
important
role
in
malignant
tumor
progression.
Recently,
accumulating
evidence
has
shown
that
autophagy
involved
regulation
EMT-induced
migration.
Therefore,
exploration
targets
to
inhibit
EMT
by
targeting
important.
In
this
study,
we
found
OVO-like
zinc
finger
2
(OVOL2)
may
be
a
key
target
for
regulating
autophagy-induced
EMT.
Firstly,
OVOL2
expression
was
dramatically
downregulated
LUAD.
Low
indicator
poor
prognosis
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Dec. 18, 2023
Metastatic
dissemination
of
solid
tumors,
a
leading
cause
cancer-related
mortality,
underscores
the
urgent
need
for
enhanced
insights
into
molecular
and
cellular
mechanisms
underlying
metastasis,
chemoresistance,
mechanistic
backgrounds
individuals
whose
cancers
are
prone
to
migration.
The
most
prevalent
signaling
cascade
governed
by
multi-kinase
inhibitors
is
mitogen-activated
protein
kinase
(MAPK)
pathway,
encompassing
RAS-RAF-MAPK
(MEK)-extracellular
signal-related
(ERK)
pathway.
RAF
primary
mediator
MAPK
responsible
sequential
activation
downstream
targets,
such
as
MEK
transcription
factor
ERK,
which
control
numerous
physiological
processes,
including
organism
development,
cell
cycle
control,
proliferation
differentiation,
survival,
death.
Defects
in
this
associated
with
diseases
cancer.
(RAFi)
combined
blockers
represent
an
FDA-approved
therapeutic
strategy
RAF-mutant
cancers,
melanoma,
non-small
lung
carcinoma,
thyroid
However,
development
therapy
resistance
cancer
cells
remains
important
barrier.
Autophagy,
intracellular
lysosome-dependent
catabolic
recycling
process,
plays
critical
role
RAFi
Thus,
targeting
autophagy
could
be
novel
treatment
strategies
cancers.
In
review,
we
delve
deeper
surrounding
tumorigenesis
RAFi-resistance.
Furthermore,
explore
discuss
ongoing
next-generation
profiles.
Additionally,
review
sheds
light
on
functional
interplay
between
RAF-targeted
therapies
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
163, P. 114866 - 114866
Published: May 12, 2023
Artemisinin
(ART)
is
a
bioactive
compound
isolated
from
the
plant
Artemisia
annua
and
has
been
traditionally
used
to
treat
conditions
such
as
malaria,
cancer,
viral
infections,
bacterial
some
cardiovascular
diseases,
especially
in
Asia,
North
America,
Europe
other
parts
of
world.
This
comprehensive
review
aims
update
biomedical
potential
ART
its
derivatives
for
treating
human
diseases
highlighting
pharmacokinetic
pharmacological
properties
based
on
results
experimental
studies
vitro
vivo.
Cellular
molecular
mechanisms
action,
tested
doses
toxic
effects
artemisinin
were
also
described.
The
analysis
data
an
up-to-date
literature
search
showed
that
display
anticancer
along
with
wide
range
activities
antibacterial,
antiviral,
antimalarial,
antioxidant
cardioprotective
effects.
These
compounds
have
great
discovering
new
drugs
adjunctive
therapies
cancer
various
diseases.
Detailed
translational
are
however
needed
fully
understand
these
compounds.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(9)
Published: Sept. 1, 2024
Abstract
Cell
death
regulation
is
essential
for
tissue
homeostasis
and
its
dysregulation
often
underlies
cancer
development.
Understanding
the
different
pathways
of
cell
can
provide
novel
therapeutic
strategies
battling
cancer.
This
review
explores
several
key
mechanisms
apoptosis,
necroptosis,
autophagic
death,
ferroptosis,
pyroptosis.
The
research
gap
addressed
involves
a
thorough
analysis
how
these
be
precisely
targeted
therapy,
considering
tumor
heterogeneity
adaptation.
It
delves
into
genetic
epigenetic
factors
signaling
cascades
like
phosphatidylinositol
3‐kinase/protein
kinase
B/mammalian
target
rapamycin
(PI3K/AKT/mTOR)
mitogen‐activated
protein
kinase/extracellular
signal‐regulated
(MAPK/ERK)
pathways,
which
are
critical
death.
Additionally,
interaction
microenvironment
with
cells,
particularly
influence
hypoxia,
nutrient
deprivation,
immune
cellular
interactions,
explored.
Emphasizing
strategies,
this
highlights
emerging
modulators
inducers
such
as
B
lymphoma
2
(BCL2)
homology
domain
3
(BH3)
mimetics,
tumour
necrosis
factor‐related
apoptosis‐inducing
ligand
(TRAIL),
chloroquine,
innovative
approaches
to
induce
ferroptosis
provides
insights
therapy's
future
direction,
focusing
on
multifaceted
circumvent
drug
resistance.
examination
evolving
underlines
considerable
clinical
potential
continuous
necessity
in‐depth
exploration
within
scientific
domain.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 5, 2023
Background
Gastric
cancer
(GC)
represents
a
malignancy
with
multi-factorial
combination
of
genetic,
environmental,
and
microbial
factors.
Targeting
lysosomes
presents
significant
potential
in
the
treatment
numerous
diseases,
while
lysosome-related
genetic
markers
for
early
GC
detection
have
not
yet
been
established,
despite
implementing
this
process
by
assembling
artificial
intelligence
algorithms
would
greatly
break
through
its
value
translational
medicine,
particularly
immunotherapy.
Methods
To
end,
study,
utilizing
transcriptomic
as
well
single
cell
data
integrating
20
mainstream
machine-learning
(ML)
algorithms.
We
optimized
an
AI-based
predictor
diagnosis.
Then,
reliability
model
was
initially
confirmed
results
enrichment
analyses
currently
use.
And
immunological
implications
genes
comprising
explored
response
patients
were
evaluated
to
immunotherapy
chemotherapy.
Further,
we
performed
systematic
laboratory
work
evaluate
build-up
central
genes,
both
at
expression
stage
functional
aspect,
which
could
also
demonstrate
guide
Results
Eight
lysosomal-related
selected
predictive
construction
based
on
inclusion
RMSE
reference
standard
RF
algorithm
ranking,
namely
ADRB2,
KCNE2,
MYO7A,
IFI30,
LAMP3,
TPP1,
HPS4,
NEU4.
Taking
into
account
accuracy,
precision,
recall,
F1
measurements,
preliminary
determination
our
study
carried
out
means
applying
extra
tree
random
forest
algorithms,
incorporating
ROC-AUC
consideration,
Extra
Tree
seems
be
optimal
option
AUC
0.92.
The
superiority
diagnostic
signature
is
reflected
analysis
immune
features.
Conclusion
In
summary,
first
integrate
around
ML
construct
gastric
genes.
This
will
facilitate
accurate
prediction
incidence
subsequent
risk
assessment
or
precise
individualized
immunotherapy,
thus
improving
survival
prognosis
patients.
Current Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
31(32), P. 5178 - 5198
Published: Feb. 2, 2024
Cancer
is
a
complex
and
heterogeneous
malignant
disease.
Due
to
its
multifactorial
nature,
including
progressive
changes
in
genetic,
epigenetic,
transcript,
protein
levels,
conventional
therapeutics
fail
save
cancer
patients.
Evidence
indicates
that
dysregulation
of
microRNA
(miRNA)
expression
plays
crucial
role
tumorigenesis,
metastasis,
cell
proliferation,
differentiation,
metabolism,
signaling
pathways.
Moreover,
miRNAs
can
be
used
as
diagnostic
prognostic
markers
therapeutic
targets
cancer.
Berberine,
naturally
occurring
plant
alkaloid,
has
wide
spectrum
biological
activities
different
types
cancers.
Inhibition
migration,
invasion,
angiogenesis,
well
induction
cycle
arrest
apoptosis
cells,
reported
by
berberine.
Recent
studies
suggested
berberine
regulates
many
oncogenic
tumor
suppressor
implicated
phases
This
review
discussed
how
inhibits
growth
propagation
cells.
And
berberine-mediated
miRNA
regulation
the
landscape
transcripts
proteins
promote
or
suppress
progression.
Overall,
underlying
molecular
pathways
altered
influencing
pathophysiology
will
enhance
our
understanding
combat
malignancy.
