Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1393 - 1393
Published: Oct. 31, 2024
Chronic
kidney
disease
(CKD)
represents
a
significant
global
health
challenge,
affecting
millions
of
individuals
and
leading
to
substantial
morbidity
mortality.
This
review
aims
explore
the
epidemiology,
cardiovascular
complications,
management
strategies
associated
with
CKD,
emphasizing
importance
preventing
early
intervention.
CKD
is
primarily
driven
by
conditions
such
as
diabetes
mellitus,
hypertension,
diseases,
which
often
coexist
exacerbate
renal
impairment.
Effective
requires
multifaceted
approach,
including
lifestyle
modifications,
pharmacological
interventions,
regular
monitoring.
Dietary
changes,
sodium
restriction
controlled
intake
phosphorus
potassium,
play
vital
role
in
preserving
function.
Pharmacological
therapies,
particularly
angiotensin-converting
enzyme
(ACE)
inhibitors,
angiotensin
receptor
blockers
(ARBs),
emerging
agents
like
SGLT2
have
shown
efficacy
slowing
progression
improving
patient
outcomes.
Furthermore,
patients
undergoing
dialysis
face
increased
risk,
necessitating
comprehensive
address
both
cardiac
health.
As
landscape
treatment
evolves,
ongoing
research
into
novel
therapeutic
options
personalized
medical
approaches
are
essential.
underscores
urgent
need
for
awareness,
education,
effective
preventive
measures
mitigate
burden
enhance
quality
life
affected
individuals.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3881 - 3881
Published: March 30, 2024
Epigenetic
changes
are
in
gene
expression
that
do
not
involve
alterations
to
the
DNA
sequence.
These
lead
establishing
a
so-called
epigenetic
code
dictates
which
and
when
genes
activated,
thus
orchestrating
regulation
playing
central
role
development,
health,
disease.
The
brain,
being
mostly
formed
by
cells
undergo
renewal
process
throughout
life,
is
highly
prone
risk
of
leading
neuronal
death
neurodegenerative
disorders,
mainly
at
late
age.
Here,
we
review
main
modifications
have
been
described
with
particular
attention
on
those
related
onset
developmental
anomalies
or
conditions
and/or
occurring
old
methylation
several
types
histone
(acetylation,
methylation,
phosphorylation,
ubiquitination,
sumoylation,
lactylation,
crotonylation)
major
players
these
processes.
They
directly
indirectly
involved
neurodegeneration
Alzheimer's
Parkinson's
Therefore,
this
briefly
describes
roles
mechanisms
brain
maturation,
aging
some
most
important
factors
dynamically
regulating
contributing
changes,
such
as
oxidative
stress,
inflammation,
mitochondrial
dysfunction.
Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(2), P. 37 - 37
Published: March 1, 2024
Vitamin
D
is
a
natural
photoproduct
that
has
many
beneficial
effects
on
different
organs,
including
skin.
Active
forms
of
vitamin
and
its
derivatives
exert
biological
skin
cells,
thus
maintaining
homeostasis.
In
keratinocytes,
they
inhibit
proliferation
stimulate
differentiation,
have
anti-inflammatory
properties,
act
as
antioxidants,
DNA
damage
repair
after
ultraviolet
(UV)
exposure.
melanocytes,
also
cell
proliferation,
apoptosis
antioxidants.
fibroblasts,
affect
fibrotic
processes
collagen
production,
promote
wound
healing
regeneration.
On
the
other
hand,
cells
ability
to
activate
directly.
These
activities,
along
with
projected
topical
application
derivatives,
are
promising
for
care
photo
protection
can
be
used
in
prevention
or
possible
reversal
aging.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1062 - 1062
Published: Aug. 30, 2024
Neurodegenerative
diseases
encompass
a
spectrum
of
disorders
marked
by
the
progressive
degeneration
structure
and
function
nervous
system.
These
conditions,
including
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
Amyotrophic
lateral
sclerosis
(ALS),
Multiple
(MS),
often
lead
to
severe
cognitive
motor
deficits.
A
critical
component
neurodegenerative
pathologies
is
imbalance
between
pro-oxidant
antioxidant
mechanisms,
culminating
in
oxidative
stress.
The
brain's
high
oxygen
consumption
lipid-rich
environment
make
it
particularly
vulnerable
damage.
Pro-oxidants
such
as
reactive
nitrogen
species
(RNS)
(ROS)
are
continuously
generated
during
normal
metabolism,
counteracted
enzymatic
non-enzymatic
defenses.
In
diseases,
this
balance
disrupted,
leading
neuronal
This
systematic
review
explores
roles
stress,
gut
microbiota,
epigenetic
modifications
aiming
elucidate
interplay
these
factors
identify
potential
therapeutic
strategies.
We
conducted
comprehensive
search
articles
published
2024
across
major
databases,
focusing
on
studies
examining
relationships
redox
homeostasis,
changes
neurodegeneration.
total
161
were
included,
comprising
clinical
trials,
observational
studies,
experimental
research.
Our
findings
reveal
that
stress
plays
central
role
pathogenesis
with
microbiota
composition
significantly
influencing
balance.
Specific
bacterial
taxa
markers
identified
modulators
suggesting
novel
avenues
for
intervention.
Moreover,
recent
evidence
from
human
animal
supports
emerging
concept
targeting
homeostasis
through
therapies.
Future
research
should
focus
validating
targets
settings
exploring
personalized
medicine
strategies
based
individual
profiles.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(6)
Published: March 14, 2025
With
the
growing
elderly
population
and
increasing
incidence
of
various
aging-related
diseases,
scientific
community
is
faced
with
an
urgent
challenge
to
identify
natural
anti-aging
agents.
Traditional
Chinese
medicine
(TCM)
polysaccharides
have
been
proven
good
activities.
This
article
reviews
literature
on
pathways
traditional
applied
Caenorhabditis
elegans
models
in
past
decade.
In
our
study,
we
found
that
45
TCM
from
28
genera
26
families
could
delay
aging
process
C.
elegans.
mainly
by
anti-oxidative
stress,
eliminating
free
radicals,
repairing
DNA
damage,
insulin/insulin-like
growth
factor
signaling
pathway
(IIS
pathway).
addition,
number
prolong
lifespan
reducing
inflammation,
regulating
intestinal
flora,
affecting
immune
cell
function.
this
paper,
was
used
as
animal
model
clarify
polysaccharides,
so
provide
theoretical
guidance
for
future
research
clinical
experiments
effect
polysaccharides.
