Immunity Inflammation and Disease,
Journal Year:
2024,
Volume and Issue:
12(10)
Published: Oct. 1, 2024
Abstract
Background
Phytochemicals
possess
a
wide
range
of
anti‐tumor
properties,
including
the
modulation
autophagy
and
regulation
programmed
cell
death.
Autophagy
is
critical
process
in
cellular
homeostasis
its
dysregulation
associated
with
several
pathological
conditions,
such
as
cancer,
neurodegenerative
diseases,
diabetes.
In
plays
dual
role
by
either
promoting
tumor
growth
or
suppressing
it,
depending
on
context.
During
autophagy,
autophagosomes
engulf
cytoplasmic
components
proteins
organelles.
LC3‐II
(microtubule‐associated
protein
1
light
chain
3‐II)
an
established
marker
autophagosome
formation,
making
it
central
to
monitoring
mammals.
Objective
To
explore
regulatory
phytochemicals
LC3‐mediated
their
potential
therapeutic
impact
cancer.
The
review
emphasizes
involvement
promotion
suppression,
particularly
focusing
autophagy‐related
signaling
pathways
like
oxidative
stress
through
NRF2
pathway,
implications
for
genomic
stability
cancer
development.
Methods
focuses
comprehensive
analysis
bioactive
compounds
Curcumin,
Celastrol,
Resveratrol,
Kaempferol,
Naringenin,
Carvacrol,
Farnesol,
Piperine.
Literature
these
was
examined
assess
influence
LC3
expression,
tumor‐related
pathways.
A
systematic
literature
search
conducted
across
databases
PubMed,
Scopus,
Web
Science
from
inception
2023.
Studies
were
selected
prominent
databases,
roles
diagnosis
interventions,
relation
mechanisms.
Results
have
been
shown
modulate
levels
autophagic
flux
cells.
interaction
between
other
stress,
inflammation,
epigenetic
highlights
complex
biology.
For
instance,
Curcumin
Resveratrol
reported
induce
inhibit
type,
influencing
progression
responses.
Conclusion
Targeting
presents
promising
strategy
therapy.
suppression
promotion,
however,
necessitates
careful
consideration
context
which
induced
inhibited.
Future
research
should
aim
delineate
context‐specific
how
can
be
optimized
efficacy.
Novel
strategies
focus
use
fine‐tune
thereby
maximizing
inducing
death
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(13), P. e34032 - e34032
Published: July 1, 2024
Thyroid
cancer
is
the
most
common
malignant
tumor
of
endocrine
system,
and
evidence
suggests
that
post-translational
modifications
(PTMs)
epigenetic
alterations
play
an
important
role
in
its
development.
Recently,
there
has
been
increasing
linking
dysregulation
ubiquitinating
enzymes
deubiquitinases
with
thyroid
cancer.
This
review
aims
to
summarize
our
current
understanding
ubiquitination-modifying
cancer,
including
their
regulation
oncogenic
pathways
proteins.
The
development
progression
requires
further
study,
which
will
provide
new
insights
into
prevention,
treatment
novel
agents.
Cells,
Journal Year:
2024,
Volume and Issue:
13(14), P. 1186 - 1186
Published: July 12, 2024
Autophagy,
an
intrinsic
catabolic
mechanism
that
eliminates
misfolded
proteins,
dysfunctional
organelles,
and
lipid
droplets,
plays
a
vital
function
in
energy
balance
cytoplasmic
quality
control,
addition
to
maintaining
cellular
homeostasis.
Liver
cancer
such
as
hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
causes
deaths
globally
shows
resistance
several
anticancer
drugs.
Despite
rising
incidence
poor
prognosis
malignant
HCC,
underlying
molecular
mechanisms
driving
this
aggressive
remain
unclear.
Several
natural
compounds,
phytochemicals
dietary
non-dietary
origin,
affect
hepatocarcinogenesis
signaling
pathways
vitro
vivo,
which
may
help
prevent
treat
HCC
cells.
Current
cells
treatments
include
chemotherapy,
radiation,
surgery.
However,
these
standard
therapies
have
substantial
side
effects,
combination
therapy
enhances
effects
for
acceptable
therapeutic
benefit.
Therefore,
there
need
develop
treatment
strategies
are
more
efficacious
fewer
adverse
effects.
Multiple
genetic
epigenetic
factors
responsible
become
resistant
treatment.
Autophagy
contributes
maintain
homeostasis,
activates
autophagy
biosynthesis
mitochondrial
regulation
recycling.
modifying
autophagic
would
present
promising
opportunity
identify
novel
current
treatments.
This
comprehensive
review
illustrates
how
compounds
demonstrate
their
anti-hepatocellular
through
autophagy.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 26, 2023
Diabetes
mellitus
(DM)
is
a
chronic
metabolic
disorder
that
affects
multiple
organs
and
systems,
including
the
pulmonary
system.
Pulmonary
dysfunction
in
DM
patients
has
been
observed
studied
for
years,
but
underlying
mechanisms
have
not
fully
understood.
In
addition
to
traditional
such
as
production
accumulation
of
advanced
glycation
end
products
(AGEs),
angiopathy,
tissue
glycation,
oxidative
stress,
systemic
inflammation,
recent
studies
focused
on
programmed
cell
deaths
(PCDs),
especially
non-apoptotic
ones,
diabetic
dysfunction.
Non-apoptotic
PCDs
(NAPCDs)
autophagic
death,
necroptosis,
pyroptosis,
ferroptosis,
copper-induced
death
found
certain
correlations
with
diabetes
relevant
complications.
The
AGE–AGE
receptor
(RAGE)
axis
only
plays
an
important
role
pathogenesis
lung
disease
also
death.
this
review,
we
summarize
novel
about
roles
focus
their
interactions
AGE–RAGE
axis.
Immunity Inflammation and Disease,
Journal Year:
2024,
Volume and Issue:
12(10)
Published: Oct. 1, 2024
Abstract
Background
Phytochemicals
possess
a
wide
range
of
anti‐tumor
properties,
including
the
modulation
autophagy
and
regulation
programmed
cell
death.
Autophagy
is
critical
process
in
cellular
homeostasis
its
dysregulation
associated
with
several
pathological
conditions,
such
as
cancer,
neurodegenerative
diseases,
diabetes.
In
plays
dual
role
by
either
promoting
tumor
growth
or
suppressing
it,
depending
on
context.
During
autophagy,
autophagosomes
engulf
cytoplasmic
components
proteins
organelles.
LC3‐II
(microtubule‐associated
protein
1
light
chain
3‐II)
an
established
marker
autophagosome
formation,
making
it
central
to
monitoring
mammals.
Objective
To
explore
regulatory
phytochemicals
LC3‐mediated
their
potential
therapeutic
impact
cancer.
The
review
emphasizes
involvement
promotion
suppression,
particularly
focusing
autophagy‐related
signaling
pathways
like
oxidative
stress
through
NRF2
pathway,
implications
for
genomic
stability
cancer
development.
Methods
focuses
comprehensive
analysis
bioactive
compounds
Curcumin,
Celastrol,
Resveratrol,
Kaempferol,
Naringenin,
Carvacrol,
Farnesol,
Piperine.
Literature
these
was
examined
assess
influence
LC3
expression,
tumor‐related
pathways.
A
systematic
literature
search
conducted
across
databases
PubMed,
Scopus,
Web
Science
from
inception
2023.
Studies
were
selected
prominent
databases,
roles
diagnosis
interventions,
relation
mechanisms.
Results
have
been
shown
modulate
levels
autophagic
flux
cells.
interaction
between
other
stress,
inflammation,
epigenetic
highlights
complex
biology.
For
instance,
Curcumin
Resveratrol
reported
induce
inhibit
type,
influencing
progression
responses.
Conclusion
Targeting
presents
promising
strategy
therapy.
suppression
promotion,
however,
necessitates
careful
consideration
context
which
induced
inhibited.
Future
research
should
aim
delineate
context‐specific
how
can
be
optimized
efficacy.
Novel
strategies
focus
use
fine‐tune
thereby
maximizing
inducing
death
