Extrapulmonary Comorbidities Associated with Chronic Obstructive Pulmonary Disease: A Review

International Journal of COPD, Journal Year: 2024, Volume and Issue: Volume 19, P. 567 - 578

Published: Feb. 1, 2024

Abstract: Most patients with chronic obstructive pulmonary disease (COPD) suffer from at least one additional, clinically relevant disease. To a degree, the high global prevalence and mortality rate of COPD is closely related to its extrapulmonary effects. Moreover, various comorbidities itself interact each other, resulting in diverse clinical manifestations individual differences, thus further influencing prognosis as well healthcare burden patients. This common risk factors diseases (aging, smoking, inactivity, etc.). Additionally, some pathophysiological mechanisms caused by COPD, including systemic inflammatory response, hypoxia, oxidative stress, others, also have an impact on other systems. But comprehensive management medical interventions not yet been established. The clinicians should improve their knowledge skills diagnosing treating then aim develop more individualized, efficient diagnostic therapeutic strategies for different achieve greater benefits. In this article, we will review factors, mechanisms, treatment disease, cardiovascular diseases, diabetes, anemia, osteoporosis, emotional disorders, gastroesophageal reflux Keywords: comorbidity, therapeutics

Language: Английский

---

Advanced glycation end products and reactive oxygen species: uncovering the potential role of ferroptosis in diabetic complications

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Sept. 9, 2024

Language: Английский

---

AGE-RAGE Axis and Cardiovascular Diseases: Pathophysiologic Mechanisms and Prospects for Clinical Applications

Cardiovascular Drugs and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Advanced glycation end products (AGE), a diverse array of molecules generated through non-enzymatic glycosylation, in conjunction with the receptor advanced (RAGE), play crucial role pathogenesis diabetes and its associated complications. Recent studies have revealed that AGE-RAGE axis potentially accelerated progression cardiovascular diseases, including heart failure, atherosclerosis, myocarditis, pulmonary hypertension, arrhythmia, other related conditions. The is intricately involved initiation independently engagement diabetes. mechanisms include oxidative stress, inflammation, alterations autophagy flux, mitochondrial dysfunction. Conversely, inhibition AGE production, disruption binding between RAGE ligands, or silencing expression could effectively impair function axis, thereby delaying ameliorating aforementioned diseases. soluble for (sRAGE) potential to be novel predictors In this review, we provide an in-depth overview towards biosynthetic pathway elucidate pathophysiological implications various Furthermore, delve into profound offering insights further exploration strategies prevention management disorders.

Language: Английский

---

Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 135, P. 112304 - 112304

Published: May 21, 2024

Activating angiotensin-converting enzyme 2 (ACE2) is an important player in the pathogenesis of septic-related acute respiratory distress syndrome (ARDS). Rosmarinic acid (RA) as a prominent polyphenolic secondary metabolite derived from Rosmarinus officinalis modulates ACE2 sepsis remains unclear, although its impact on ACE inhibition and septic-associated lung injury has been explored. The study investigated expression lipopolysaccharide (LPS)-induced lungs mice BEAS2B cells. Additionally, molecular docking, protein-protein interaction (PPI) network analysis, western blotting were employed to predict evaluate mechanism RA LPS-induced ferroptosis vivo vitro. glutathione peroxidase 4 (GPX4) downregulation, ACE/ACE2 imbalance, alteration frequency breathing (BPM), minute volume (MV), expiratory flow at 50% expired (EF

Language: Английский

---

From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.

Language: Английский

---

Research Progress of Diabetes and Lung Impairment

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(08), P. 134 - 141

Published: Jan. 1, 2024

Language: Английский

---

Integrating Single-Cell and Bulk Rna Sequencing to Identify Disulfidptosis-Related Gene Signature, Immune Landscape, and Immunotherapy Targets in Cutaneous Melanoma

Published: Jan. 1, 2024

Language: Английский

---