Current genetic test for ovarian cancer

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(1), P. 8 - 10

Published: Jan. 1, 2025

Language: Английский

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Antibody–drug conjugates (ADCs) may be a big breakthrough in gynecologic cancer treatment (II): Anti-HER2/neu

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(6), P. 820 - 822

Published: Oct. 30, 2024

Language: Английский

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Antibody–drug conjugates (ADCs) may be a big breakthrough in gynecologic cancer treatment (I)

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(6), P. 817 - 819

Published: Oct. 30, 2024

Language: Английский

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Lymphedema and sentinel lymph node mapping

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(1), P. 4 - 5

Published: Jan. 1, 2025

Language: Английский

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Primary cytoreductive surgery for advanced epithelial ovarian cancer patients is still popular in gynecologic oncologists in Korea and Taiwan, particularly apparent in Taiwan

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(1), P. 1 - 3

Published: Jan. 1, 2025

Language: Английский

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Expression of female hormone receptor and prognosis of cervical cancer: Does any relationship exist?

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(1), P. 6 - 7

Published: Jan. 1, 2025

Language: Английский

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Menopause part I: Vasomotor symptoms (I)

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(2), P. 230 - 238

Published: March 1, 2025

Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production estrogen) without another pathological or physiological cause becomes one the most health issues in world. Vasomotor symptoms (VMS) is a hallmark menopause, occurring up 80 % women experiencing and persisting for over seven years with significant negative impacts on physical, psychological, social, overall wellbeing. Conventionally, menopause hormone therapy (MHT) considered effective therapeutic opinion many based fact as "deficiency estrogen"; however, ratio benefits risk highly debated always concern. Therefore, non-MHT agent focusing underlying pathophysiology VMS, such hypothalamus-pituitary-ovary axis becoming attractive. Based this concept, hypothalamus neural construct containing Kisspeptin (Kp) neurons median pre-optic area (POA) Kp-neurokinin B (NKB)-dynorphin (DYN) (KNDy neurons) infundibular nucleus identified thermoregulatory circultry involve normal reproduction menopause-associated VMS. The neurokinin 3 receptor (NK3R) antagonists applied VMS are enthusiasm big success. Fezolinetant best breakthroughs. Recent three randomized clinical trials (RCTs), including SKYLIGHT 1,2, 4 confirmed safety efficacy treating moderate-to-severe women. By contrast, MONGLIGHT RCTs East Asia population seemed controversial effect treatment, but there no doubt that issue also satisfied, contributing need more validate its diverse population. current review will summary recent advance new landscape management particularly focus fezolinetant product.

Language: Английский

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Application of 2023 FIGO staging system for 2019 FIGO stage I endometrial cancer

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(2), P. 210 - 212

Published: March 1, 2025

Language: Английский

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Is it enough to use cisplatin-paclitaxel-bevacizumab along in the management of stage IVB cervical cancer patients?

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(2), P. 207 - 209

Published: March 1, 2025

Language: Английский

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Gambogic Acid Based Coordination Polymer Reinforces High‐Intensity Focused Ultrasound Treatment of Gynecologic Malignancies

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract High‐intensity focused ultrasound (HIFU) is emerging as a promising non‐invasive treatment for solid tumors. Nevertheless, HIFU may also induce the upregulation of Heat Shock Protein 90 (HSP‐90), potentially resulting in resistance to HIFU. Besides, although it effective against situ tumors, challenges remain with tumor metastasis and recurrence. Herein, innovative design gambogic acid (GA) based coordination polymer—GAZn‐PEG nanoparticles (GAZn‐PEG NPs) are synthesized through GA zinc ions (Zn 2+ ), subsequently functionalized lipid bilayer incorporating polyethylene glycol (PEG), sensitizing cervical ovarian cancers. Briefly, under exposure, markedly suppresses expression HSP‐90, thereby increasing tumor's sensitivity therapy. Furthermore, Zn not only overcome issue GA's poor water solubility but synergistically stimulate immune responses conjunction GA. More intriguingly, has been discovered that GAZn‐PEG can effectively activate cyclic GMP‐AMP synthase‐stimulator interferon genes (cGAS‐STING) pathway, enhancing provoked by Specifically, NPs show remarkable increase dendritic cell activation stimulation cGAS‐STING crucial long‐term protection recurrence metastasis.

Language: Английский

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