Therapeutic detoxification of quercetin for aflatoxin B1-related toxicity: Roles of oxidative stress, inflammation, and metabolic enzymes

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123474 - 123474

Published: Feb. 1, 2024

Language: Английский

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Integrating magnetic-plasmonic and membrane-like nanotags for the sensitive and reliable detection of aflatoxin B1 in foodstuffs

Food Control, Journal Year: 2025, Volume and Issue: unknown, P. 111144 - 111144

Published: Jan. 1, 2025

Language: Английский

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Nanobiosensors for aflatoxin B1 detection, current research trends and future outlooks

Microchemical Journal, Journal Year: 2023, Volume and Issue: 194, P. 109344 - 109344

Published: Sept. 9, 2023

Language: Английский

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Monitoring Mycotoxin Exposure in Food-Producing Animals (Cattle, Pig, Poultry, and Sheep)

Toxins, Journal Year: 2024, Volume and Issue: 16(5), P. 218 - 218

Published: May 9, 2024

Food-producing animals are exposed to mycotoxins through ingestion, inhalation, or dermal contact with contaminated materials. This exposure can lead serious consequences for animal health, affects the cost and quality of livestock production, even impact human health foods origin. Therefore, controlling mycotoxin in is utmost importance. A systematic literature search was conducted this study retrieve results monitoring food-producing over last five years (2019–2023), considering both external (analysis feed) internal biomarkers biological matrices). The most commonly used analytical technique approaches LC-MS/MS due its capability multidetection. Several mycotoxins, especially those that regulated (ochratoxin A, zearalenone, deoxynivalenol, aflatoxins, fumonisins, T-2, HT-2), along some emerging (sterigmatocystin, nivalenol, beauvericin, enniantins among others), were studied 13,818 feed samples worldwide typically detected at low levels, although they occasionally exceeded regulatory levels. occurrence multiple widespread. Regarding biomonitoring, primary objective studies retrieved metabolism after toxin administration. Some compounds have been suggested as plasma, urine, feces species such pigs poultry. However, further research required, including many other species, cattle sheep.

Language: Английский

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Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 452 - 452

Published: April 11, 2024

Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity association with spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, cancer. Lycopene, lipid-soluble natural carotenoid, has emerged as potential mitigator deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity, nephrotoxicity, intestinal damage, reproductive impairment. This protective mechanism operates reducing oxidative stress, inflammation, lipid peroxidation, activating mitochondrial apoptotic pathway, facilitating activation biogenesis, endogenous antioxidant system, nuclear factor erythroid 2-related 2 (Nrf2)/kelch-like ECH-associated protein 1 (KEAP1) peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) pathways, well regulating activities cytochrome P450 (CYP450) enzymes. review provides an overview lycopene against exposure-induced underlying molecular mechanisms. Furthermore, it explores profile clinical applications lycopene. The present underscores lycopene’s promising detoxification agent intent to stimulate further research practical utilization in this domain.

Language: Английский

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Effects of Green-Synthesised Copper Oxide–Zinc Oxide Hybrid Nanoparticles on Antifungal Activity and Phytotoxicity of Aflatoxin B1 in Maize (Zea mays L.) Seed Germination

Agronomy, Journal Year: 2025, Volume and Issue: 15(2), P. 313 - 313

Published: Jan. 26, 2025

Maize contamination with aflatoxin B1 (AFB1) is of significance on a global scale due to its major contribution food security. It very probable that substantial amounts AFB1 may be absorbed by germinating seeds grown in contaminated soil and cause deleterious effects the growth development maize. In this study, effect green-synthesised ZnO-CuO hybrid nanoparticles (NPs) antifungal activity reducing toxic seed germination was examined. A notable inhibitory A. flavus observed at concentration 0.5 ppm, resulting 13.1% inhibition, which more effective than higher 1.0 ppm control. The results showed final percentage were inoculated 320 ppb significantly increased treatment 125 mg/mL green NPs. This study indicated potential NPs as alternative agents control production maize improve security safety supressing threat posed AFB1.

Language: Английский

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Urinary markers/metabolites of exposure to chemical carcinogens - New possibilities in preventive oncology

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 269, P. 115774 - 115774

Published: Dec. 6, 2023

Centuries have passed without tobacco medical evaluation, and similar catastrophes happened from the Roman Empire to now. We are not aware when, how much our body is exposed chemical carcinogens every day. As a result of such exposure, millions people fall ill with malignant diseases year. The objectives this work are: 1) Determination main urinary markers exposure most dangerous carcinogens; 2) Globally raising awareness about necessity scientific testing chemicals before widespread human use; 3) Introducing public ubiquity of: As, Ni, Cr(VI), Cd, Be, maximal reducing people′s them. There well known causal relations between different types diseases. Population based studies may determine persons high concentrations markers/metabolites carcinogens. Then, selected should be removed circumstances and/or regularly checked. Better solution find out source(s) incriminated cancerogens eliminate or mitigate their emission. These kind (pre)screening (primordial prevention) for risk developing causally related

Language: Английский

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Recent developments of mycotoxin-degrading enzymes: identification, preparation and application

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(27), P. 10089 - 10104

Published: June 9, 2023

Mycotoxins are secondary metabolites produced by fungi during their growth. They not only seriously affect the yield of food crops but also pose a threat to human and animal health. Physical chemical methods have been widely used reduce production accumulation mycotoxins in field or after harvest, these difficulty completely removing while keeping nutrients at same time. Biodegradation using isolated enzymes shown superiority potential for modest reaction conditions, high degradation efficiency products with low toxicity. Therefore, occurrence, structures, toxicology six prevalent (deoxynivalenol, zearalenone, aflatoxin, patulin, fumonisin, ochratoxin) were described this manuscript. The identification application mycotoxin-degrading thoroughly reviewed. It is believed that near future, expected be commercially developed feed industries.

Language: Английский

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Isolation and characterization of mycotoxins and their control

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 397 - 414

Published: Jan. 1, 2025

Language: Английский

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Recent Progress of Mycotoxin in Various Food Products—Human Exposure and Health Risk Assessment

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 865 - 865

Published: March 3, 2025

Mycotoxins, as prevalent contaminants in the food chain, exhibit diverse toxicological effects on both animals and humans. Chronic dietary exposure to mycotoxin-contaminated foods may result bioaccumulation of these toxins, posing substantial public health risks. This review systematically examines contamination patterns mycotoxins across major categories, including cereals related products, animal-derived foods, fruits, medical materials. Furthermore, we critically evaluated two methodological frameworks for assessing mycotoxin risks: (1) models integrating levels consumption data (2) human biomonitoring approaches quantifying biomarkers biological samples. A key contribution lies stratified analysis disparities among population subgroups (adults, teenagers, children, infants). Additionally, summarize current research relationship between associated impacts, with a particular emphasis vulnerable groups such pregnant women infants. By elucidating challenges inherent existing studies, this synthesis provides roadmap advancing risk characterization evidence-based safety interventions.

Language: Английский

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