Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats DOI Open Access

Alaa Muqbil Alsirhani,

Amal S. Abu-Almakarem,

Maha Abdullah Alwaili

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12541 - 12541

Published: Nov. 22, 2024

Doxorubicin (DOX), an anticancer drug, is used to treat several types of tumors, but it has detrimental side effects that restrict its therapeutic efficacy. One the iron-dependent form ferroptosis, which characterized by elevated ROS production and iron overload.

Language: Английский

Ratiometric Fluorescent Probe for Super-Resolution Imaging of Lysosome HClO in Ferroptosis Cells DOI

Hongyong Zheng,

Weikang Peng, Miaomiao Liu

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Ferroptosis is an iron-dependent programmed cell death that characterized by the dysregulation of lipid reactive oxygen species (ROS) production, causing abnormal changes in hypochlorous acid (HClO) levels lysosomes. Super-resolution imaging can observe fine structure lysosome at nanometer level; therefore, it be used to detect HClO during ferroptosis suborganelle level. Herein, we utilize a ratiometric fluorescent probe,

Language: Английский

Citations

14
6PPD impairs growth performance by inducing intestinal oxidative stress and ferroptosis in zebrafish DOI
Hao Xu,

Xiaoyu Mao,

Dashuang Mo

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2025, Volume and Issue: 293, P. 110161 - 110161

Published: Feb. 21, 2025

Language: Английский

Citations

0
Nanostructured aptasensors for ricin detection and tumor therapy: exploring aptamer-protein interactions and conformational stability in biological complexities DOI
Minahil Hayat, Sayyad Ali Raza Bukhari, Mohsan Raza

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143282 - 143282

Published: April 1, 2025

Language: Английский

Citations

0
Discovery of phenazine derivatives as a new class of non-classical ferroptosis inhibitors and efficacy evaluation on a mouse model of liver injury DOI
Yunjie Wu, Yang Lu, Jing You

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 282, P. 117042 - 117042

Published: Nov. 12, 2024

Language: Английский

Citations

0
Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats DOI Open Access

Alaa Muqbil Alsirhani,

Amal S. Abu-Almakarem,

Maha Abdullah Alwaili

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12541 - 12541

Published: Nov. 22, 2024

Doxorubicin (DOX), an anticancer drug, is used to treat several types of tumors, but it has detrimental side effects that restrict its therapeutic efficacy. One the iron-dependent form ferroptosis, which characterized by elevated ROS production and iron overload.

Language: Английский

Citations

0