Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring? DOI Creative Commons
Cheryl S. Rosenfeld

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1628 - 1628

Published: July 23, 2024

Endocrine-disrupting chemicals (EDCs) have become so pervasive in our environment and daily lives that it is impossible to avoid contact with such compounds, including pregnant women seeking minimize exposures themselves their unborn children. Developmental exposure of humans rodent models bisphenol A (BPA) other EDCs linked increased anxiogenic behaviors, learning memory deficits, decreased socio-sexual behaviors. Prenatal BPA leads longstanding harmful effects on gut microbiota reductions beneficial bacteria, i.e., dysbiosis, microbial changes are host fecal metabolites, those involved carbohydrate metabolism synthesis, neurobehavioral alterations adulthood, particular, social cognitive deficits. Gut dysbiosis increasingly being recognized as a key driver myriad diseases, ranging from metabolic, cardiovascular, reproductive, disorders via the gut-microbiome-brain axis. Thus, might induce indirect physical mental health by acting microbiome-disrupting chemicals. Findings raise important question whether should consume probiotic supplement mitigate pernicious EDCs, especially BPA, offspring. Current studies investigating maternal supplementation women's offspring will be reviewed. Data inform potential application reverse unwittingly exposed these compounds striving give best start life.

Language: Английский

Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2 DOI

Chunfeng Xie,

Xinyao Jiang, Juan Yin

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137166 - 137166

Published: Jan. 9, 2025

Language: Английский

Citations

1
Uterine Microbiota and Bisphenols: Novel Influencers in Reproductive Health DOI Creative Commons

Dafne Castellanos‐Ruiz,

J. Gerardo Ojeda-Borbolla,

Olga V. Ruiz-García

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 26 - 26

Published: Feb. 2, 2025

Infertility affects 8–12% of couples worldwide, and 30–75% preclinical pregnancy losses are due to a failure during the implantation process. Exposure endocrine disruptors, like bisphenols, among others, has been associated with increase in infertility observed past decades. An correlated exposure disruptors bisphenols. The uterus harbors its own microbiota, changes this microbiota have linked several gynecological conditions, including reproductive failure. There no studies on effects bisphenols uterine–microbiota composition, but some inferences can be gleaned by looking at gut. Bisphenols alter gut molecular mechanism which regulates intestinal permeability involves Toll-like receptors (TLRs) tight junction (TJ) proteins. TJs participate embryo uterus, bisphenol disrupts expression localization TJ aim review is summarize current knowledge female tract (FRT), association different diseases—particularly failure—the composition health, mechanisms regulating interactions crucial for implantation. This also highlights existing gaps outlines research needs future risk assessments regarding reproduction.

Language: Английский

Citations

0
Environmental contamination by bisphenols: from plastic production to modulation of the intestinal morphophysiology in experimental models DOI

Beatriz Gouvêa de Luca,

Patrícia Pereira Almeida, Reinaldo Röpke

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115280 - 115280

Published: Feb. 1, 2025

Language: Английский

Citations

0
Sexual dimorphism in neurobehavioural phenotype and gut microbial composition upon long-term exposure to structural analogues of bisphenol-A DOI
Dhirendra Singh, Ashish Kumar, Jignesh Prajapati

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135178 - 135178

Published: July 11, 2024

Language: Английский

Citations

3
Metabolic disrupting chemicals in the intestine: the need for biologically relevant models DOI Creative Commons
Chedi Erradhouani, Sylvie Bortoli, Sélim Aı̈t-Aı̈ssa

et al.

FEBS Open Bio, Journal Year: 2024, Volume and Issue: 14(9), P. 1397 - 1419

Published: Sept. 1, 2024

Although the concept of endocrine disruptors first appeared almost 30 years ago, relatively recent involvement these substances in etiology metabolic pathologies (obesity, diabetes, hepatic steatosis, etc.) has given rise to Metabolic Disrupting Chemicals (MDCs). Organs such as liver and adipose tissue have been well studied context disruption by substances. The intestine, however, unexplored despite its close link with organs. In vivo models are useful for study effects MDCs intestine and, addition, allow investigations into interactions rest organism. latter respect, zebrafish is an animal model which used increasingly characterization use a assessing on will, no doubt, expand. This review aims highlight importance metabolism present relevant alternative investigating effect pollutants focusing, particular, cytochrome P450 3A (CYP3A), one major molecular players endogenous gut.

Language: Английский

Citations

3
Environmental microbial diversity and water pollution characteristics resulted from 150 km coastline in Quanzhou Bay offshore area DOI Creative Commons

Siqi Ding,

Jiamin Chang,

Wen‐Zhou Zhang

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

As a typical transitional area between the land and sea, offshore is subjected to triple synergistic pressure from ocean, land, atmosphere at same time, has obvious characteristics such as complex diverse chemical, physical, biological processes, coupled changeable environmental factors, sensitive fragile ecological environment. With deepening of urbanization process, gradually become final receptions pollutants produced by industry, agriculture, service industries, plays key role in global geochemical cycle pollutants. In this study, Quanzhou Bay was selected research object. Sediment water samples were collected 8 sampling points within about 150 km coastline area. 16s rDNA high-throughput sequencing method used investigate variation rule microbial diversity area, multi-parameter quality analysis carried out time. The results showed that distribution communities significant differences different latitudes longitudes. This difference closely related complexity study can provide scientific support for protecting improving environment areas.

Language: Английский

Citations

1
Influence of bisphenol A and its analogues on human gut microbiota composition and metabolic activity: Insights from an in vitro model DOI
Paulina Średnicka, Marek Roszko, Paulina Emanowicz

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 956, P. 177323 - 177323

Published: Nov. 6, 2024

Language: Английский

Citations

1
Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring? DOI Creative Commons
Cheryl S. Rosenfeld

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1628 - 1628

Published: July 23, 2024

Endocrine-disrupting chemicals (EDCs) have become so pervasive in our environment and daily lives that it is impossible to avoid contact with such compounds, including pregnant women seeking minimize exposures themselves their unborn children. Developmental exposure of humans rodent models bisphenol A (BPA) other EDCs linked increased anxiogenic behaviors, learning memory deficits, decreased socio-sexual behaviors. Prenatal BPA leads longstanding harmful effects on gut microbiota reductions beneficial bacteria, i.e., dysbiosis, microbial changes are host fecal metabolites, those involved carbohydrate metabolism synthesis, neurobehavioral alterations adulthood, particular, social cognitive deficits. Gut dysbiosis increasingly being recognized as a key driver myriad diseases, ranging from metabolic, cardiovascular, reproductive, disorders via the gut-microbiome-brain axis. Thus, might induce indirect physical mental health by acting microbiome-disrupting chemicals. Findings raise important question whether should consume probiotic supplement mitigate pernicious EDCs, especially BPA, offspring. Current studies investigating maternal supplementation women's offspring will be reviewed. Data inform potential application reverse unwittingly exposed these compounds striving give best start life.

Language: Английский

Citations

0