Microplastics are everywhere — but are they harmful?

Nature, Journal Year: 2021, Volume and Issue: 593(7857), P. 22 - 25

Published: May 4, 2021

Language: Английский

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Polystyrene microplastics induced male reproductive toxicity in mice

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 401, P. 123430 - 123430

Published: July 7, 2020

Language: Английский

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Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Particle and Fibre Toxicology, Journal Year: 2020, Volume and Issue: 17(1)

Published: Nov. 12, 2020

Abstract Background Together with poor biodegradability and insufficient recycling, the massive production use of plastics have led to widespread environmental contamination by nano- microplastics. These particles accumulate across ecosystems - even in most remote habitats are transferred through food chains, leading inevitable human ingestion, that adds highest one due processes packaging. Objective The present review aimed at providing a comprehensive overview current knowledge regarding effects microplastics on intestinal homeostasis. Methods We conducted literature search focused vivo gut epithelium microbiota, as well immune response. Results Numerous animal studies shown exposure leads impairments oxidative inflammatory balance, disruption gut’s epithelial permeability. Other notable microplastic include dysbiosis (changes microbiota) cell toxicity. Moreover, contain additives, adsorb contaminants, may promote growth bacterial pathogens their surfaces: they potential carriers toxicants can potentially lead further adverse effects. Conclusion Despite scarcity reports directly relevant human, this brings together growing body evidence showing disturbs microbiota critical functions. Such development chronic disorders. Further investigation threat health is warranted.

Language: Английский

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Microplastic sources, formation, toxicity and remediation: a review

Environmental Chemistry Letters, Journal Year: 2023, Volume and Issue: 21(4), P. 2129 - 2169

Published: April 4, 2023

Abstract Microplastic pollution is becoming a major issue for human health due to the recent discovery of microplastics in most ecosystems. Here, we review sources, formation, occurrence, toxicity and remediation methods microplastics. We distinguish ocean-based land-based sources Microplastics have been found biological samples such as faeces, sputum, saliva, blood placenta. Cancer, intestinal, pulmonary, cardiovascular, infectious inflammatory diseases are induced or mediated by exposure during pregnancy maternal period also discussed. Remediation include coagulation, membrane bioreactors, sand filtration, adsorption, photocatalytic degradation, electrocoagulation magnetic separation. Control strategies comprise reducing plastic usage, behavioural change, using biodegradable plastics. Global production has risen dramatically over past 70 years reach 359 million tonnes. China world's top producer, contributing 17.5% global production, while Turkey generates waste Mediterranean region, at 144 tonnes per day. 75% marine waste, with responsible 80–90% pollution, account only 10–20%. induce toxic effects on humans animals, cytotoxicity, immune response, oxidative stress, barrier attributes, genotoxicity, even minimal dosages 10 μg/mL. Ingestion animals results alterations gastrointestinal tract physiology, system depression, differential gene expression, growth inhibition. Furthermore, bioaccumulation tissues aquatic organisms can adverse ecosystem, potential transmission birds. Changing individual behaviours governmental actions, implementing bans, taxes, pricing carrier bags, significantly reduced consumption 8–85% various countries worldwide. The microplastic minimisation approach follows an upside-down pyramid, starting prevention, followed reducing, reusing, recycling, recovering, ending disposal least preferable option.

Language: Английский

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Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 405, P. 124028 - 124028

Published: Oct. 5, 2020

Language: Английский

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Polystyrene microplastics induced female reproductive toxicity in mice

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 424, P. 127629 - 127629

Published: Oct. 30, 2021

Plastics have caused serious environmental pollution. In recent years, microplastics (MPs) widespread concern about their potential toxicity on animals and humans, especially organ tissue deposition. However, there is little known the reproductive toxic effects of MPs in female mammals. this study, polystyrene (PS-MPs) mice was evaluated after continued exposure for 35 days. Results showed that PS-MPs could accumulate heart, liver, spleen, lung, kidney, brain, large intestine, small uterus, ovary blood exposed mice. Moreover, increased IL-6 level decreased malondialdehyde (MDA) mouse ovaries. The results also first polar body extrusion rate survival superovulated oocytes. Meanwhile, reduced glutathione (GSH), mitochondrial membrane (MMP), endoplasmic reticulum calcium ([Ca2+]ER) reactive oxygen species (ROS) conclusion, our study illustrated induced inflammation ovaries quality oocytes mice, which provided a basis studying mechanism

Language: Английский

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Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 806, P. 150328 - 150328

Published: Sept. 15, 2021

Language: Английский

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Potential Health Impact of Microplastics: A Review of Environmental Distribution, Human Exposure, and Toxic Effects

Environment & Health, Journal Year: 2023, Volume and Issue: 1(4), P. 249 - 257

Published: Aug. 10, 2023

Microplastics are ubiquitous in the global environment. As a typical emerging pollutant, its potential health hazards have been widely concerning. In this brief paper, we introduce source, identification, toxicity, and hazard of microplastics human. The literature review shows that frequently detected environmental human samples. Humans potentially exposed to through oral intake, inhalation, skin contact. We summarize toxic effects experimental models like cells, organoids, animals. These consist oxidative stress, DNA damage, organ dysfunction, metabolic disorder, immune response, neurotoxicity, as well reproductive developmental toxicity. addition, epidemiological evidence suggests variety chronic diseases may be related exposure. Finally, put forward gaps toxicity research their future development directions. This will helpful understanding exposure risk microplastics.

Language: Английский

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Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice

Toxicology, Journal Year: 2021, Volume and Issue: 465, P. 153059 - 153059

Published: Dec. 2, 2021

Language: Английский

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Effects of nano- and microplastics on kidney: Physicochemical properties, bioaccumulation, oxidative stress and immunoreaction

Chemosphere, Journal Year: 2021, Volume and Issue: 288, P. 132631 - 132631

Published: Oct. 21, 2021

Language: Английский

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