Microplastics in human food chains: Food becoming a threat to health safety

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 858, P. 159834 - 159834

Published: Oct. 28, 2022

Language: Английский

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From natural environment to animal tissues: A review of microplastics(nanoplastics) translocation and hazards studies

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 855, P. 158686 - 158686

Published: Sept. 10, 2022

Language: Английский

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The potential impacts of micro-and-nano plastics on various organ systems in humans

EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104901 - 104901

Published: Dec. 6, 2023

Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems not yet fully understood. This review aims provide an overview potential impacts and identify knowledge gaps in current research. The summarized results suggest that exposure can lead oxidative stress, inflammation, immune dysfunction, altered biochemical energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal development, carcinogenicity. There is limited human data MNPs, despite evidence from animal cellular studies. Most published research has focused specific types assess their toxicity, while other plastic particles commonly found environment remain unstudied. Future studies should investigate by considering realistic concentrations, dose-dependent effects, individual susceptibility, confounding factors.

Language: Английский

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A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 16, 2023

Over the years, vaste expansion of plastic manufacturing has dramatically increased environmental impact microplastics [MPs] and nanoplastics [NPs], making them a threat to marine terrestrial biota because they contain endocrine disrupting chemicals [EDCs] other harmful compounds. MPs NPs have deleteriouse impacts on mammalian components such as hypothalamus, pituitary, thyroid, adrenal, testes, ovaries. absorb act transport medium for bisphenols, phthalates, polybrominated diphenyl ether, polychlorinated biphenyl organotin, perfluorinated compounds, dioxins, polycyclic aromatic hydrocarbons, organic contaminants, heavy metals, which are commonly used additives in production. As EDCs not covalently bonded plastics, can easily leach into milk, water, liquids affecting system mammals upon exposure. The toxicity induced by is size-dependent, smaller particles better absorption capacity larger surface area, releasing more EDC toxic chemicals. Various contained or carried share structural similarities with specific hormone receptors; hence interfere normal receptors, altering hormonal action glands. This review demonstrates size-dependent MPs’ bioaccumulation, distribution, translocation potential hazards gland. We reviewed that disrupt hypothalamic-pituitary axes, including hypothalamic-pituitary-thyroid/adrenal/testicular/ovarian axis leading oxidative stress, reproductive toxicity, neurotoxicity, cytotoxicity, developmental abnormalities, decreased sperm quality, immunotoxicity. direct consequences testis, ovaries documented. Still, studies need be out identify effects adrenal

Language: Английский

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Polystyrene microplastics promote liver inflammation by inducing the formation of macrophages extracellular traps

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 452, P. 131236 - 131236

Published: March 21, 2023

Language: Английский

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A systematic review of the impacts of exposure to micro- and nano-plastics on human tissue accumulation and health

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 2(4), P. 195 - 207

Published: Aug. 21, 2023

Micro- and nano-plastics (MNPs) pollution has become a pressing global environmental issue, with growing concerns regarding its impact on human health. However, evidence the effects of MNPs health remains limited. This paper reviews three routes exposure to MNPs, which include ingestion, inhalation, dermal contact. It further discusses potential translocation in lungs, intestines, skin, analyses homeostasis organ systems, provides an outlook future research priorities for There is that are present tissues or fluids. Lab studies, including

Language: Английский

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Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 445, P. 130544 - 130544

Published: Dec. 5, 2022

Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility. However, most existing studies have focused on the adulthood stage of reproduction toxicity caused by relatively short-term PS-MP exposure. This study aimed to investigate toxic effect PS-MPs testicular development and reproductive function upon prenatal postnatal Pregnant mice their offspring were exposed 0, 0.5 mg/L, 5 50 mg/L through daily drinking water from gestational day 1 (PND) 35 or PND70. We found that exposure induced testis disorder PND35 spermatogenesis dysfunction By combining RNA sequencing results bioinformatics analysis, hormone-mediated signaling pathway, G1/S transition mitotic cell cycle, coregulation androgen receptor activity, Hippo pathway shown be involved in PND35. The meiotic regulation immune effector process, neutrophil degranulation, inflammation mediated chemokine cytokine pathways associated with disturbed These findings show resulted subfertility, which may regulated involve an reaction.

Language: Английский

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Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113230 - 113230

Published: April 7, 2022

Language: Английский

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Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis

Toxicological Sciences, Journal Year: 2024, Volume and Issue: 200(2), P. 235 - 240

Published: May 15, 2024

Abstract The ubiquitous existence of microplastics and nanoplastics raises concerns about their potential impact on the human reproductive system. Limited data exists within system consequences sperm quality. Our objectives were to quantify characterize prevalence composition both canine testes investigate associations with count, weights testis epididymis. Using advanced sensitive pyrolysis-gas chromatography/mass spectrometry, we quantified 12 types 47 23 testes. Data organ weights, count in dogs collected. Statistical analyses, including descriptive analysis, correlational multivariate linear regression analyses applied association functions. study revealed presence all testes, significant inter-individual variability. Mean total microplastic levels 122.63 µg/g 328.44 humans. Both humans canines exhibit relatively similar proportions major polymer types, PE being dominant. Furthermore, a negative correlation between specific polymers such as PVC PET normalized weight was observed. These findings highlight pervasive male fertility.

Language: Английский

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Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 454, P. 131470 - 131470

Published: April 23, 2023

Language: Английский

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