Identification and Characterization of Candidate Platelet Proteins as Potential Biomarkers for Alcoholism Patients DOI
Sangeetha P Kademani,

Vithiavathi Siva Subramanian,

Prabhudas Nelaturi

et al.

Alcoholism Treatment Quarterly, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Oct. 22, 2024

Chronic alcoholism is a significant health issue associated with severe liver complications, including alcohol-related disease (ARLD), progresses from fatty to cirrhosis and hepatocellular carcinoma. ARLD affects function hemostasis, leading increased mortality. This study intended investigate the platelet proteome detect cell apoptosis via Annexin V in patients order identify potential biomarkers for progression. Twenty-three were recruited, their proteins analyzed mass spectrometry. Approximately 441 identified, 73 candidate selected on basis of clinical importance. Key involved coagulation, inflammation, cellular interactions are highlighted. Gene ontology STRING analyses revealed functional clusters pathways these proteins. identified critical proteins, such as von Willebrand factor, vitronectin, serpin family members, which play essential roles hemostasis pathogenesis. These findings suggest that changes proteomes could serve noninvasive diagnosing, monitoring, treating ARLD.

Language: Английский

Uncovering the impact of alcohol on internal organs and reproductive health: Exploring TLR4/NF‐kB and CYP2E1/ROS/Nrf2 pathways DOI Creative Commons
Eason Qi Zheng Kong, Vetriselvan Subramaniyan, Natasha Sura Anak Lubau

et al.

Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: 7(4), P. 444 - 459

Published: June 9, 2024

This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health, elucidating underlying mechanisms involving Toll-like receptor 4 (TLR4)/Nuclear factor kappa light chain enhancer activated B cells (NF-kB) pathway Cytochrome P450 2E1 (CYP2E1)/reactive oxygen species (ROS)/nuclear erythroid 2-related 2 (Nrf2) pathways. The TLR4/NF-kB pathway, crucial for inflammatory immune responses, triggers production pro-inflammatory agents type-1 interferon, disrupting balance between antioxidant responses when tissues are chronically exposed to alcohol. Alcohol-induced dysbiosis in gut microbes heightens wall permeability pathogen-associated molecular patterns (PAMPs), leading liver cell infection subsequent inflammation. Concurrently, CYP2E1-mediated metabolism generates ROS, causing oxidative stress damaging cells, lipids, proteins, deoxyribonucleic acid (DNA). To counteract this imbalance, Nrf2 regulates gene expression, inhibiting progression promoting responses. Excessive intake results elevated enzymes (ADH, CYP2E1, catalase), NADH, acetaldehyde, acetate, damage vital such as heart, brain, lungs. Moreover, negatively affects health by hypothalamic-pituitary-gonadal axis, infertility both men women. These findings underscore profound concerns associated with alcohol-induced damage, emphasizing need public awareness regarding intricate interplay multi-organ impacts consumption.

Language: Английский

Citations

9
Effect of Tetrastigma hemsleyanum leaves and Extract supplementation on liver metabolomics and the gut microbiota in alcohol-induced liver injury DOI

Kexin Tao,

Han Peng, Xin Bi

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 58, P. 103617 - 103617

Published: Jan. 20, 2024

Language: Английский

Citations

6
Protective effects of polysaccharides from Polygonatum cyrtonema on the acute alcohol induced liver damage DOI

Yueyao Gui,

Bing Zheng, Hairong Huang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104879 - 104879

Published: Aug. 6, 2024

Language: Английский

Citations

4
Mechanism of triiodothyronine alleviating acute alcoholic liver injury and delaying alcoholic liver fibrosis progression DOI Creative Commons

Renli Luo,

Sanqiang Li,

Mengli Yang

et al.

Human & Experimental Toxicology, Journal Year: 2025, Volume and Issue: 44

Published: Feb. 1, 2025

Introduction Alcoholic liver disease poses a severe threat to human health. The thyroid hormone Triiodothyronine (T3) is closely related metabolism. This study investigated the effect and mechanism of T3 in alcoholic injury. Methods Acute injury model was established mice by alcohol administration. fibrosis models were vivo vitro using hepatic stellate cells (HSC)-T6 mice. role regulatory occurrence progression acute analyzed evaluating key factors involved cell proliferation apoptosis, inflammatory response, oxidative stress, autophagy histopathological staining. Results results showed that at low medium concentrations reduced inflammation damage inhibited HSC activation delayed onset PI3K/AKT NF-κB signal pathway, increased Nrf2 expression levels, restored autophagy. However, high had opposite effect. Discussion Optimal protects from inhibiting response stress restoring hepatocyte proliferation,

Language: Английский

Citations

0
Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights DOI Creative Commons

Padmanaban Sathiyamoorthy,

Jiwon Baek,

Sai Sahithya Chamarthy

et al.

Liver Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Mogroside V Prevents Ethanol-Induced Hangover and Liver Damage by Reducing Oxidative Stress, Steatosis and Inflammation DOI
Rui Ai, Tian Miao, J. Sun

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 766, P. 151912 - 151912

Published: April 26, 2025

Language: Английский

Citations

0
Auricularia auriculaPolysaccharides Exert Anti-inflammatory Effects in Hepatic Fibrosis by the Gut–Liver Axis and Enhancing SCFA Metabolism DOI Creative Commons
Lu Zhang, Zhaoxiu Liu, Yiheng Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Auricularia auricula, esteemed in Chinese culture for their culinary and medicinal properties, exhibits notable metabolic immunomodulatory effects. The principal active constituents are indigestible fermentable polysaccharides, which not only exhibit anti-inflammatory activities but also facilitate the proliferation of beneficial gut microbiota. However, influence gut-derived components on liver-regulated products remains insufficiently understood. This item offers insights into therapeutic potential wood ear mushrooms treating hepatic fibrosis associated mechanisms. Following 8 weeks treatment, a substantial reduction ECM deposition was recorded, linked to modulation NLRP3 inflammasome activation. study aims reveal microbiome-mediated mechanisms behind its Insights from antibiotic combination treatments indicate that protective effects against rely presence specific fecal microbiota intervention enhances key physiological mechanisms, underscoring contributions Lactobacillales, Rikenellaceae, Bacteroidaceae potentially mitigating fibrosis. Collectively, these findings suggest interventions utilizing may reduce inflammation deposition, mediated by TLR4/NF-κB pathway.

Language: Английский

Citations

0
Identification and immunological role of cuproptosis in osteoporosis DOI Creative Commons

Tongying Chen,

Zhijie Gao,

Yuedong Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26759 - e26759

Published: Feb. 20, 2024

osteoporosis is a skeletal disorder disease features low bone mass and poor architecture, which predisposes to increased risk of fracture. Copper death newly recognized form cell caused by excess copper ions, presumably involve in various disease. Accordingly, we intended investigate the molecular clusters related cuproptosis construct predictive model.

Language: Английский

Citations

2
Black rice bran extract exerts hepatoprotection via attenuating inflammation and apoptosis in obese-insulin-resistant rats DOI Creative Commons
Pongrapee Laorodphun, Aussara Panya, Hsu Myat Tin Swe

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38538 - e38538

Published: Sept. 27, 2024

Language: Английский

Citations

1
Rehabilitation of N, N'-methylenebisacrylamide-induced DNA destruction in the testis of adult rats by adipose-derived mesenchymal stem cells and conditional medium DOI Creative Commons
Mona Atia,

Aya Ahmed Badr El-Deen,

Hanem Abdel-Tawab

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(23), P. e40380 - e40380

Published: Nov. 14, 2024

Environmental pollutant acrylamide has toxic effect on human health. Numerous industries such as the paper, and cosmetics, use in their manufacturing. In certain foods, arises at extremely high temperatures. Mesenchymal stem cells can shield different tissues from damaging effects of free radicals induced by acrylamide. This study aimed to compare therapeutic efficacy against acrylamide-induced toxicity between adipose-derived mesenchymal (MSCs) conditioned media (CM), evaluating which is more effective. Seventy adult male rats were employed this study, distributed among 5 groups. The control group consisted 10 rats, while each other four groups comprised 15 rats. AC received a daily oral (AC) dosage 3 mg/kg. + AD-MSCs CM groups, after 4 weeks administration, injected with 0.65 ×

Language: Английский

Citations

0