Micromachines,
Journal Year:
2022,
Volume and Issue:
13(2), P. 200 - 200
Published: Jan. 27, 2022
Microfluidic
technology
has
been
highly
useful
in
nanovolume
sample
preparation,
separation,
synthesis,
purification,
detection
and
assay,
which
are
advantageous
drug
development.
This
review
highlights
the
recent
developments
trends
microfluidic
applications
two
areas
of
First,
we
focus
on
how
microfluidics
developed
as
a
facile
tool
for
fabrication
carriers
including
microparticles
nanoparticles.
Second,
discuss
chips
could
be
used
an
independent
platform
or
integrated
with
other
technologies
toxicity
screening.
Challenges
future
perspectives
development
have
also
provided
considering
present
technological
limitations.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(6), P. 2483 - 2509
Published: Feb. 15, 2023
New
drug
discovery
is
under
growing
pressure
to
satisfy
the
demand
from
a
wide
range
of
domains,
especially
pharmaceutical
industry
and
healthcare
services.
Assessment
efficacy
safety
prior
human
clinical
trials
crucial
part
development,
which
deserves
greater
emphasis
reduce
cost
time
in
discovery.
Recent
advances
microfabrication
tissue
engineering
have
given
rise
organ-on-a-chip,
an
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 22, 2024
Abstract
Drug
screening
based
on
in-vitro
primary
tumor
cell
culture
has
demonstrated
potential
in
personalized
cancer
diagnosis.
However,
the
limited
number
of
cells,
especially
from
patients
with
early
stage
cancer,
hindered
widespread
application
this
technique.
Hence,
we
developed
a
digital
microfluidic
system
for
drug
using
cells
and
established
working
protocol
precision
medicine.
Smart
control
logic
was
to
increase
throughput
decrease
its
footprint
parallelly
screen
three
drugs
4
×
cm
2
chip
device
measuring
23
16
3.5
3
.
We
validated
method
an
MDA-MB-231
breast
xenograft
mouse
model
liver
specimens
patients,
demonstrating
suppression
mice/patients
treated
that
were
screened
be
effective
individual
cells.
Mice
on-chip
as
ineffective
exhibited
similar
results
those
groups.
The
identified
through
consistency
absence
mutations
their
related
genes
determined
via
exome
sequencing
tumors,
further
validating
protocol.
Therefore,
technique
may
promote
advances
medicine
treatment
and,
eventually,
any
disease.
Energy & Environmental Science,
Journal Year:
2021,
Volume and Issue:
14(6), P. 3301 - 3322
Published: Jan. 1, 2021
This
review
article
presents
the
state-of-the-art
in
high-throughput
computational
and
experimental
screening
routines
with
application
organic
solar
cells,
including
materials
discovery,
device
optimization
machine-learning
algorithms.
The Analyst,
Journal Year:
2022,
Volume and Issue:
147(11), P. 2294 - 2316
Published: Jan. 1, 2022
This
review
focuses
on
the
recent
advances
in
fundamentals
of
single-cell
droplet
microfluidics
and
its
applications
biomedicine,
providing
insights
into
design
establishment
microsystems
their
further
performance.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
26, P. 101048 - 101048
Published: April 4, 2024
Biosensing
is
vital
for
many
areas
like
disease
diagnosis,
infectious
prevention,
and
point-of-care
monitoring.
Microfluidics
has
been
evidenced
to
be
a
powerful
tool
biosensing
via
integrating
biological
detection
processes
into
palm-size
chip.
Based
on
the
chip
structure,
microfluidics
two
subdivision
types:
open
closed
microfluidics,
whose
operation
methods
would
diverse.
In
this
review,
we
summarize
fundamentals,
liquid
control
methods,
applications
of
separately,
point
out
bottlenecks,
propose
potential
directions
microfluidics-based
biosensing.
Microsystems & Nanoengineering,
Journal Year:
2022,
Volume and Issue:
8(1)
Published: Jan. 17, 2022
The
rapid
and
label-free
diagnosis
of
malignancies
in
ex
vivo
breast
biopsy
tissues
has
significant
utility
pathology
laboratories
operating
rooms.
We
report
a
MEMS-based
platform
integrated
with
microchips
that
performs
phenotyping
using
electrothermal
sensing.
microchip,
fabricated
on
silicon
substrate,
incorporates
platinum
microheater,
interdigitated
electrodes
(IDEs),
resistance
temperature
detectors
(RTDs)
as
on-chip
sensing
elements.
are
onto
the
slide-fit
contact
enabling
quick
replacement
for
biological
measurements.
bulk
resistivity
(
