Recent Development of Implantable Chemical Sensors Utilizing Flexible and Biodegradable Materials for Biomedical Applications DOI
Hu Chen, Liu Wang, Shangbin Liu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3969 - 3995

Published: Jan. 25, 2024

Implantable chemical sensors built with flexible and biodegradable materials exhibit immense potential for seamless integration biological systems by matching the mechanical properties of soft tissues eliminating device retraction procedures. Compared conventional hospital-based blood tests, implantable have capability to achieve real-time monitoring high accuracy important biomarkers such as metabolites, neurotransmitters, proteins, offering valuable insights clinical applications. These innovative could provide essential information preventive diagnosis effective intervention. To date, despite extensive research on bioresorbable electronics, development has faced several challenges related design, resulting in only a limited number successful accomplishments. This review highlights recent advancements based materials, encompassing their sensing strategies, geometric configurations. The following discussions focus demonstrated detection various objects including ions, small molecules, few examples macromolecules using and/or sensors. Finally, we will present current explore future directions.

Language: Английский

Sensors for daily life: A review DOI Creative Commons
Mohd Javaid, Abid Haleem, Shanay Rab

et al.

Sensors International, Journal Year: 2021, Volume and Issue: 2, P. 100121 - 100121

Published: Jan. 1, 2021

Sensor technologies have improved the everyday life of human beings through their applications in almost all fields. Sensors are devices that detect changes source/environment and collect signals, accordingly, reaction is designed. There a range sources, including light, temperature, movements, pressure etc., which may be used. A wide utilised using innovative sensor lifestyle, healthcare, fitness, manufacturing, daily life. In medical field, difficulty to take medicine eased by drug donors fitted with sensors. It reminds them via signal also supply necessary at specified moment. health care, older individuals, athletes, risk patients benefit from modern technology. The current industrial trends driving innovation include ultrasound, radar, non-contact optoelectronic solutions laser paper gives brief overview numerous types sensors Various capabilities for day-to-day healthcare discussed. features, associated nomenclature, measures routine discussed diagrammatically finally, identifies discusses twenty-two significant produce vital information exchange data other connected administration systems when linked network. Thus, effective running many companies, critical. used our life, more accurate makes quicker analysis.

Language: Английский

Citations

284

Liposome-Mediated In Situ Formation of Type-I Heterojunction for Amplified Photoelectrochemical Immunoassay DOI
Yuan Gao, Yongyi Zeng, Xiaolong Liu

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(11), P. 4859 - 4865

Published: March 9, 2022

Exploiting innovative sensing mechanisms and their rational implementation for selective sensitive detection has recently become one of the mainstream research directions photoelectrochemical (PEC) bioanalysis. In contrast to existing conventional strategies, this study presents a new liposome-mediated method via in situ combining ZnInS nanosheets (ZIS NSs) with SnS2 form ZIS NSs/SnS2 type-I heterojunction on fluorine-doped tin oxide (FTO) electrodes highly PEC immunoassays. Specifically, alkaline phosphatase (ALP)-encapsulated liposomes were confined within 96-well plates by sandwich immunorecognition subsequently subjected lysis treatment. Enzymatically produced H2S released ALP was then directed react Sn(IV) engender FTO/ZIS NSs-Sn(IV) electrode, resulting change photogenerated electron–hole transfer path photoelectrode reduction current signaling. Exemplified heart-type fatty acid binding protein (h-FABP) as target, constructed sensor showed good stability selectivity biosensing system. Under optimal conditions, as-prepared platform displayed high sensitivity h-FABP dynamic linear response range 0.1–1000 pg/mL lower limit 55 fg/mL. This immunoassay based establishment, providing protocol analyzing various targets interest.

Language: Английский

Citations

209

Applications of two-dimensional layered nanomaterials in photoelectrochemical sensors: A comprehensive review DOI
Yunlei Zhou, Huanshun Yin, Shiyun Ai

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 447, P. 214156 - 214156

Published: Aug. 14, 2021

Language: Английский

Citations

203

An Overview on SARS-CoV-2 (COVID-19) and Other Human Coronaviruses and Their Detection Capability via Amplification Assay, Chemical Sensing, Biosensing, Immunosensing, and Clinical Assays DOI Creative Commons
Yasin Orooji, Hessamaddin Sohrabi, Nima Hemmat

et al.

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 13(1)

Published: Nov. 2, 2020

Abstract A novel coronavirus of zoonotic origin (SARS-CoV-2) has recently been recognized in patients with acute respiratory disease. COVID-19 causative agent is structurally and genetically similar to SARS bat SARS-like coronaviruses. The drastic increase the number its genome sequence have given us an unprecedented opportunity perform bioinformatics genomics analysis on this class viruses. Clinical tests like PCR ELISA for rapid detection virus are urgently needed early identification infected patients. However, these techniques expensive not readily available point-of-care (POC) applications. Currently, lack any rapid, available, reliable POC method gives rise progression as a horrible global problem. To solve negative features clinical investigation, we provide brief introduction general coronaviruses describe various amplification assays, sensing, biosensing, immunosensing, aptasensing determination groups applied template SARS-CoV-2. All sensing biosensing developed classes useful recognize newly immerged coronavirus, i.e., Also, methods sheds light way designing proper screening system detect at stage infection tranquilize speed vastity spreading. Among other approaches investigated among molecular or recognition viral diseases, LAMP-based LFAs great importance their numerous benefits, which can be helpful design universal platform future emerging pathogenic

Language: Английский

Citations

196

Exploiting Photoelectric Activities and Piezoelectric Properties of NaNbO3 Semiconductors for Point-of-Care Immunoassay DOI
Zhichao Yu,

Hexiang Gong,

Jianhui Xu

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(7), P. 3418 - 3426

Published: Feb. 11, 2022

Point-of-care testing (POCT) technology has made major breakthroughs in community medicine and physician office situations, tandem with the more ubiquitous intensive usage of highly integrated quick detection equipment for illness diagnosis, personal care, mobile healthcare. Although photoelectrochemical (PEC)-based POCT platform offers benefits cheap cost good user engagement, its commercialization is still limited by photodetection components' downsizing mobility, among other factors. In this work, a novel PEC biosensor aided piezophototronics to enhance efficiency was reported flexible cancer-associated antigens biological fluids (prostate-specific antigen, PSA, used as an example). Multiple signal enhancement strategies, including magnetic bead-linked enzyme-linked immune system catalyzing production ascorbic acid from substrate piezoelectric-assisted strategy, were sensitive analyte be tested human body fluids. Unlike electron transfer mechanism heterojunctions, piezoelectric semiconductors promote electrons holes generating potentials ultrasonic field, thus contributing performance testbed. Under optimized conditions, test achieves correspondence PSA at 0.02–40 ng mL–1. Impressively, devices are comparable or even superior gold standard ELISA kits terms approval batch testing. This research demonstrates potential POC applications revolutionary PECs innovative thoughts development new bioanalytical components.

Language: Английский

Citations

191

Chemiluminescence-Derived Self-Powered Photoelectrochemical Immunoassay for Detecting a Low-Abundance Disease-Related Protein DOI
Zhichao Yu,

Hexiang Gong,

Yuxuan Li

et al.

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 93(39), P. 13389 - 13397

Published: Sept. 23, 2021

Early diagnosis of cancers relies on the sensitive detection specific biomarkers, but most current testing methods are inaccessible to home healthcare due cumbersome steps, prolonged time, and utilization toxic hazardous substances. Herein, we developed a portable self-powered photoelectrochemical (PEC) sensing platform for rapid prostate-specific antigen (PSA, as model disease-related protein) by integrating photoelectric signal output system catalyzed with chemiluminescence-functionalized Au nanoparticles (AuNPs) phosphomolybdic acid (PMA)-based photochromic visualization platform. TiO2-g-C3N4-PMA photosensitive materials were first synthesized functionalized sensor chip. The consisted filter paper modified photocatalytic material regional laser-etched FTO electrode an alternative conventional PEC glass-based electrode. targeting involved monoclonal anti-PSA capture antibody-functionalized Fe3O4 magnetic bead (mAb1-MB) polyclonal antibody (pAb2)-N-(4-aminobutyl)-N-ethylisoluminol-AuNP (ABEI-AuNP). Based intensity chemiluminescent system, device color changed from light yellow heteropoly blue through PMA integrated into output. In addition, electrical in was amplified sandwich-type capacitor readout handheld digital multimeter. Under optimum conditions, exhibited high sensitivity relative PSA range 0.01–50 ng mL–1 low limit 6.25 pg mL–1. flow-through chemiluminescence reactor semiautomatic injection separation avoid unstable source inherent process. Therefore, our strategy provides new horizon point-of-care analysis cost-effective clinical diagnosis.

Language: Английский

Citations

157

Application of MXene in Electrochemical Sensors: A Review DOI
Xinzhao Wu, Pinyi Ma, Ying Sun

et al.

Electroanalysis, Journal Year: 2021, Volume and Issue: 33(8), P. 1827 - 1851

Published: May 19, 2021

Abstract Electroanalysis has obtained considerable progress over the past few years, especially in field of electrochemical sensors. Broadly speaking, sensors include not only conventional biosensors or non‐biosensors, but also emerging electrochemiluminescence (ECL) and photoelectrochemical (PEC) which are both combined with optical methods. In addition, various sensing devices have been developed for practical purposes, such as multiplexed simultaneous detection disease‐related biomarkers non‐invasive body fluid monitoring. For further performance improvement sensors, material is crucial. Recent a kind two‐dimensional (2D) nanomaterial MXene containing transition metal carbides, nitrides carbonitrides, unique structural, mechanical, electronic, optical, thermal properties, attracted lot attention form analytical chemists, widely applied Here, we reviewed based on from Nov. 2014 (when first work about sensor published) to Mar. 2021, dividing them into different types biosensors, flexible We believe this review will be help those who want design develop MXene, hoping new inspirations could sparked.

Language: Английский

Citations

156

Mycotoxins’ Toxicological Mechanisms Involving Humans, Livestock and Their Associated Health Concerns: A Review DOI Creative Commons
Chinaza Godswill Awuchi, Erick Nyakundi Ondari,

Sarah O. Nwozo

et al.

Toxins, Journal Year: 2022, Volume and Issue: 14(3), P. 167 - 167

Published: Feb. 24, 2022

Mycotoxins are well established toxic metabolic entities produced when fungi invade agricultural/farm produce, and this happens especially the conditions favourable. Exposure to mycotoxins can directly take place via consumption of infected foods feeds; humans also be indirectly exposed from consuming animals fed with feeds. Among hundreds known humans, around a handful have drawn most concern because their occurrence in food severe effects on human health. The increasing public health importance across livestock environments mandates continued review relevant literature, regard understanding toxicological mechanisms. In particular, our analysis recently conducted reviews showed that mechanisms deserve additional attention help provide enhanced regarding subject matter. For reason, current work reviewed mycotoxins' involving livestock, associated concerns. we deepened about how impact cellular genome. Along significance mycotoxin toxicities mechanisms, there concerns arising exposures these toxins, including DNA damage, kidney DNA/RNA mutations, growth impairment children, gene modifications, immune impairment. More needs done enhance regards underscoring environmental implications mycotoxins, which actualized risk assessment studies into conditions/factors facilitating toxicities.

Language: Английский

Citations

143

Nanostructure-based photoelectrochemical sensing platforms for biomedical applications DOI
Zhenli Qiu, Dianping Tang

Journal of Materials Chemistry B, Journal Year: 2020, Volume and Issue: 8(13), P. 2541 - 2561

Published: Jan. 1, 2020

As a newly developed and powerful analytical method, the use of photoelectrochemical (PEC) biosensors opens up new opportunities to provide wide applications in early diagnosis diseases, environmental monitoring food safety detection. The properties diverse photoactive materials are one essential factors, which can greatly impact PEC performance. continuous development nanotechnology has injected vitality into field biosensors. In many studies, much effort on sensing with semiconductor is highlighted. Thus, we propose systematic introduction recent progress nanostructure-based exploit more promising advanced technologies. This review briefly evaluates several nanomaterials an emphasis charge separation transfer mechanism over past few years. addition, introduce application research sensors from perspective basic principles, give brief overview main advances versatile pattern platforms. last section covers aspects future prospects challenges analysis field.

Language: Английский

Citations

141

Photoinduced Electron Transfer Modulated Photoelectric Signal: Toward an Organic Small Molecule-Based Photoelectrochemical Platform for Formaldehyde Detection DOI
Yuan Gao, Zhichao Yu, Lingting Huang

et al.

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(23), P. 9130 - 9137

Published: May 30, 2023

Photoelectrochemical (PEC) sensing has been rapidly evolving in recent years, while the introduction of small molecules with specific recognition functions into interface remains a nascent area study. In this work, we reported PEC biosensor for formaldehyde (FA) detection based on photoinduced electron transfer (PET)-gated injection between organic and inorganic semiconducting substrates. Specifically, an FA-responsive probe (NA-FA-COOH) TiO2 nanoarrays were integrated to construct platform (NFC/TiO2) via coordination bond. NFC served simultaneously as target-specific element modulator injection. Treatment NFC/TiO2 by FA would suppress intramolecular PET process, quenched photocurrent signal due changed carrier pathway, thus establishing effective modulation. The proposed system exhibited high selectivity sensitivity, low limit 0.071 μM. This study presents novel perspective use effect advanced bioanalysis.

Language: Английский

Citations

134