MOFs and MOF-Derived Materials for Antibacterial Application

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(4), P. 215 - 215

Published: Nov. 3, 2022

Bacterial infections pose a serious threat to people’s health. Efforts are being made develop antibacterial agents that can inhibit bacterial growth, prevent biofilm formation, and kill bacteria. In recent years, materials based on metal organic frameworks (MOFs) have attracted significant attention for various applications due their high specific surface area, enzyme-like activity, continuous release of ions. This paper reviews the progress MOFs as agents, focusing preparation methods, fundamental mechanisms, strategies enhance effects. Finally, several prospects related application proposed, aiming provide possible research directions in this field.

Language: Английский

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Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy

Matter, Journal Year: 2023, Volume and Issue: 6(3), P. 761 - 799

Published: Feb. 3, 2023

Language: Английский

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Engineering Cell Membranes: From Extraction Strategies to Emerging Biosensing Applications

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 7880 - 7894

Published: Jan. 25, 2024

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVReviewNEXTEngineering Cell Membranes: From Extraction Strategies to Emerging Biosensing ApplicationsJing TanJing TanCollege of Chemistry and Materials Science, Nanjing Normal University, 210023, P.R. ChinaMore by Jing TanView Biography, Chengcheng ZhuChengcheng ZhuCollege ZhuView Lulu LiLulu LiCollege Environmental Chemical Engineering, Jiangsu University Science Technology, Zhenjiang 212000, LiView Biographyhttps://orcid.org/0000-0001-6781-1826, Jin Wang*Jin WangCollege China*[email protected]More WangView Biographyhttps://orcid.org/0000-0003-4525-9924, Xing-Hua XiaXing-Hua XiaState Key Laboratory Analytical for Life XiaView Biographyhttps://orcid.org/0000-0001-9831-4048, Chen Wang*Chen ChinaState Biographyhttps://orcid.org/0000-0001-6544-4065Cite this: Anal. Chem. 2024, XXXX, XXX, XXX-XXXPublication Date (Web):January 25, 2024Publication History Received22 April 2023Accepted4 January 2024Revised1 August 2023Published online25 2024https://doi.org/10.1021/acs.analchem.3c01746© 2024 American SocietyRequest reuse permissionsArticle Views572Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biosensing,Cells,Membranes,Nanoparticles,Plasma membrane Get e-Alerts

Language: Английский

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Biomembrane‐coated nanosystems as next‐generation delivery systems for the treatment of gastrointestinal cancers

Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Gastrointestinal cancers, a major global cause of cancer‐related mortality and disease burden, are heterogeneous group malignant aliments involving different organs the digestive system. The late clinical diagnosis, genomic tumor heterogeneity, high complexity gastrointestinal microenvironment, along with increasing treatment resistance have been recognized as main contributing factors to current inadequacy interventions poor prognosis cancer patients. In coming years, is unfortunately predicted increase due absence early detection effective therapeutic options. Biomembrane‐coated biomimetic nanoparticles (NPs) recently appointed advanced nanotechnological tools for management cancers. These comprise not only cell‐mimicking nanodevices (the pioneers this top‐down coating technology), but also exosome bacterial mimetics. Due their enhanced bio‐interfacing features, biocompatibility, immune evasion, specific targetability tumorous tissues, these nanostructures successfully exploited provide safer, effective, targeted applications. This review highlights latest research on biomembrane‐coated nanosystems therapy diagnosis most common deadliest subtypes namely colorectal cancer, gastric liver esophageal pancreatic cancer. challenges toward translation mentioned.

Language: Английский

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One-Step Synthesis and Oriented Immobilization of Strep-Tag II Fused PDGFRβ for Screening Intracellular Domain-Targeted Ligands

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(28), P. 11479 - 11487

Published: June 29, 2024

Accurate orientations and stable conformations of membrane receptor immobilization are particularly imperative for accurate drug screening ligand-protein affinity analysis. However, there remain challenges associated with (1) traditional recombination, purification, receptors, which time-consuming labor-intensive; (2) the on stationary phase not easily controlled. Herein, a novel one-step synthesis oriented-immobilization membrane-receptor chromatography (oSOMAC) method was developed to realize high-throughput targeting specific domains receptors. We employed Strep-tag II as noncovalent tag fused into platelet-derived growth factor β (PDGFRβ) through CFPS, meanwhile, Strep-Tactin-modified monolithic columns prepared in batches. The advantages oSOMAC follows: targeted receptors can be expressed independent living cell within 1-2 h; orientation flexibly controlled active sites expose accurately; (3) synthesized, purified, orientation-immobilized one step. Accordingly, three potential PDGFRβ intracellular domain ligands: tanshinone IIA (Tan IIA), hydroxytanshinone IIA, dehydrotanshinone were successfully screened out from

Language: Английский

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Screening of CPT1A-Targeting Lipid Metabolism Modulators Using Mitochondrial Membrane Chromatography

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(10), P. 13234 - 13246

Published: Feb. 27, 2024

Carnitine palmitoyltransferase 1A (CPT1A), which resides on the mitochondrial outer membrane, serves as rate-limiting enzyme of fatty acid β-oxidation. Identifying compounds targeting CPT1A warrants a promising candidate for modulating lipid metabolism. In this study, we developed CPT1A-overexpressed membrane chromatography (MMC) to screen with affinity CPT1A. Cells overexpressing were cultured, and subsequently, their was isolated immobilized amino-silica gel cross-linked by glutaraldehyde. After packing column, retention components MMC performed LC/MS, whose analytic peaks provided structural information that might interact proteins. With newly MMC-LC/MS approach, several Chinese traditional medicine extracts, such Scutellariae Radix Polygoni Cuspidati Rhizoma et (PCRR), analyzed. Five noteworthy compounds, baicalin, baicalein, wogonoside, wogonin, resveratrol, identified enhancers activity, resveratrol being new agonist The study suggests reliable screening system efficiently identifying modulators from complex extracts.

Language: Английский

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An emerging paradigm to develop analytical methods based on immobilized transmembrane proteins and its applications in drug discovery

TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 157, P. 116728 - 116728

Published: July 4, 2022

Language: Английский

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Advances in receptor chromatography for drug discovery and drug–receptor interaction studies

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(6), P. 103576 - 103576

Published: March 31, 2023

Language: Английский

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Genetically Engineered Cell Membrane-Coated Nanoparticles with High-Density Customized Membrane Receptor for High-Performance Drug Lead Discovery

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 7, 2023

Cell membrane coating strategies have been increasingly researched due to their unique capabilities of biomimicry and biointerfacing, which can mimic the functionality original source cells in vivo but fail provide customized nanoparticle surfaces with new or enhanced beyond natural cells. However, field drug lead discovery necessitates acquisition sufficient surface density specific target receptors, presenting a heightened demand for this technology. In study, we developed novel approach fabricate high fibroblast growth factor receptor 4 (FGFR4) cell membrane-coated nanoparticles through covalent site-specific immobilization between genetically engineered FGFR4 HaloTag anchor on chloroalkane-functionalized magnetic nanoparticles. This technique enables efficient screening tyrosine kinase inhibitors from products. And were successfully confirmed by Western blot assay confocal laser scanning microscopy. Further, demonstrated exceptional sensitivity (limit detection = 0.3 × 10-3 μg mL-1). Overall, proposed design achieved anchor, demonstrates promising strategy development engineering. highlights potential technology facilitating advanced extraction small molecules discovery.

Language: Английский

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Rationally Designed Cell Membrane Biomimetic Biosensing Platform for the Binding Analysis of Drugs with Intracellular Kinase Domain of Epidermal Growth Factor Receptor

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Biosensing technologies have demonstrated significant potential in exploring the binding of drugs to receptor tyrosine kinases (RTKs). As a typical transmembrane receptor, there are still several shortcomings utilization intracellular kinase domain RTKs, primary action site small-molecule inhibitors, resulting insufficient and unclear sites, which impair efficiency accuracy biosensing. Herein, using epidermal growth factor (EGFR) as an example, we reported biosensing platform based on cell membrane camouflage technology for evaluating EGFR. The azide-functionalized membranes modified through glucose metabolism were reverse-coated onto alkyne-functionalized magnetic nanoparticles via bioorthogonal reaction (CMRMNPs), therefore effectively exposing EGFR without damage. To construct platform, fluorescent probe derived from gefitinib pharmacophore (GN probe) was further synthesized incubated with CMRMNPs. This strategy facilitated efficient localization GN within Ultimately, this approach successfully implemented evaluate three inhibitors study provides viable constructing biomimetic biosensors defined orientation offers novel insights methodologies drug regions RTKs.

Language: Английский

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