Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(11), P. 1615 - 1615

Published: Nov. 15, 2023

Antibiotics have revolutionized medicine, saving countless lives since their discovery in the early 20th century. However, origin of antibiotics is now overshadowed by alarming rise antibiotic resistance. This global crisis stems from relentless adaptability microorganisms, driven misuse and overuse antibiotics. article explores subsequent emergence It delves into mechanisms employed bacteria to develop resistance, highlighting dire consequences drug including compromised patient care, increased mortality rates, escalating healthcare costs. The elucidates latest strategies against drug-resistant encompassing innovative approaches such as phage therapy, CRISPR-Cas9 technology, exploration natural compounds. Moreover, it examines profound impact resistance on development, rendering pursuit new economically challenging. limitations challenges developing novel are discussed, along with hurdles regulatory process that hinder progress this critical field. Proposals for modifying facilitate development presented. withdrawal major pharmaceutical firms research examined, potential re-engage interest. also outlines initiatives overcome economic incentivize emphasizing international collaborations partnerships. Finally, sheds light government-led a specific focus Middle East. discusses proactive measures taken governments region, Saudi Arabia United Arab Emirates, combat threat. In face multifaceted approach imperative. provides valuable insights complex landscape challenges, collaborative efforts required ensure future where remain effective tools safeguarding public health.

Language: Английский

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Synthesis of Metal–Organic Framework-Based ZIF-8@ZIF-67 Nanocomposites for Antibiotic Decomposition and Antibacterial Activities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(51), P. 49244 - 49258

Published: Dec. 12, 2023

Toxic antibiotic effluents and antibiotic-resistant bacteria constitute a threat to global health. So, scientists are investigating high-performance materials for decomposition antibacterial activities. In this novel research work, we have successfully designed ZIF-8@ZIF-67 nanocomposites via sol-gel solvothermal approaches. The nanocomposite is characterized by various techniques that exhibit superior surface area enhancement, charge separation, high light absorption performance. Yet, ZIF-8 has adsorption rates active sites, while ZIF-67 larger pore volume efficient reaction capabilities, demonstrating the outperforms pristine ZIF-67. Compared with ZIF-67, most 6ZIF-67@ZIF-8 showed higher efficacy ciprofloxacin (65%), levofloxacin (54%), ofloxacin (48%). Scavenger experiments confirmed

Language: Английский

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Bio-inspired sustainable synthesis of silver nanoparticles as next generation of nanoproduct in antimicrobial and catalytic applications

Materials Science and Engineering B, Journal Year: 2024, Volume and Issue: 301, P. 117165 - 117165

Published: Jan. 5, 2024

Language: Английский

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MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: March 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Language: Английский

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A roadmap of recent advances in MXene@MOF hybrids, its derived composites: Synthesis, properties, and their utilization as an electrode for supercapacitors, rechargeable batteries and electrocatalysis

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 80, P. 110293 - 110293

Published: Jan. 5, 2024

Language: Английский

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Synergetic Antibacterial Nanoparticles with Broad‐Spectrum for Wound Healing and Lung Infection Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 10, 2024

Abstract The problem of antimicrobial resistance (AMR) caused by the abuse antibiotics is becoming serious. development antibacterial materials with synergistic efficiency and treatment deep tissue/organ infections imminent. Herein, nanoparticles (MPH NPs) are prepared loading peptide polymyxin B (PMB) on Fe‐based MOF (MIL‐100) hyaluronic acid (HA) modification. MPH NPs exerts effects chemodynamic therapy (CDT) release PMB. have broad‐spectrum properties Gram‐negative bacteria ( E. coli , 100%), Gram‐positive S. aureus 98.5 %), MRSA (98.4%). Importantly, not only promote healing infected wounds but also target lungs to accomplish organ infection therapy. Therefore, this study provides a new strategy for designing synergetic anti‐AMR system function in future.

Language: Английский

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Fe-Based Metal Organic Frameworks (Fe-MOFs) for Bio-Related Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1599 - 1599

Published: May 26, 2023

Metal–organic frameworks (MOFs) are porous materials composed of metal ions and organic ligands. Due to their large surface area, easy modification, good biocompatibility, MOFs often used in bio-related fields. Fe-based metal–organic (Fe-MOFs), as important types MOF, favored by biomedical researchers for advantages, such low toxicity, stability, high drug-loading capacity, flexible structure. Fe-MOFs diverse widely used. Many new have appeared recent years, with modification methods innovative design ideas, leading the transformation from single-mode therapy multi-mode therapy. In this paper, therapeutic principles, classification, characteristics, preparation methods, applications years reviewed understand development trends existing problems Fe-MOFs, view provide ideas directions future research.

Language: Английский

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Metal-organic framework membrane for waterborne micro/nanoplastics treatment

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 474, P. 145715 - 145715

Published: Aug. 29, 2023

Micro/nanoplastics (MPs/NPs) are widespread and pose a significant threat to the environment. Conventional polymeric membrane filtration struggles completely remove MPs/NPs from water wastewater. However, metal–organic frameworks (MOFs)-based membranes have gained attention due their potential in tunable hydrophilicity, pore structure, low surface roughness, dual charge, compatibility with matrix materials, resistance biofouling. This article critically analyzes factors affecting performance of MOF removing MPs/NPs, interaction mechanism, limitations conventional systems, advantages membranes. Despite promising potential, MOF-based also face challenges such as re-aggregation nanoparticles, cross-contamination during poor structural stability. paper discusses how mitigate these problems by incorporating different materials MOFs. Overall, high

Language: Английский

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Multifunctional metal–organic frameworks for wound healing and skin regeneration

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112252 - 112252

Published: Aug. 18, 2023

Various wounds caused by burns, trauma, surgery, and genetic irregularities, including acute chronic wounds, pose a huge burden on global healthcare. Many therapeutic strategies, such as nanomedicine regenerative medicine, have been applied to wound repair skin regeneration. As promising exciting nanomaterial, metal-organic frameworks (MOFs) encompass many desirable properties, crystalline porous structure, tunable size, good mechanical stability, large specific surface area, exceptional chemical stability. Most importantly, the performance of MOFs can be modulated changing synthesis steps conditions. release metal ions modulate cellular behaviors kill various microorganisms, which meets this dual agent strategy for healing Additionally, act carriers delivering bioactive agents in desired manner. Recently, an increasing number researchers conducted studies applying Based this, we perform study report current status further perspective MOFs-based strategy. Furthermore, molecular process fabrication were also discussed.

Language: Английский

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Environmental implications of metal–organic frameworks and MXenes in biomedical applications: a perspective

RSC Advances, Journal Year: 2023, Volume and Issue: 13(49), P. 34562 - 34575

Published: Jan. 1, 2023

Metal-organic frameworks (MOFs) and MXenes have demonstrated immense potential for biomedical applications, offering a plethora of advantages. MXenes, in particular, exhibit robust mechanical strength, hydrophilicity, large surface areas, significant light absorption potential, tunable terminations, among other remarkable characteristics. Meanwhile, MOFs possess high porosity area, making them ideal protecting active biomolecules serving as carriers drug delivery, hence their extensive study the field biomedicine. However, akin to (nano)materials, concerns regarding environmental implications persist. The number studies investigating toxicity biocompatibility is growing, albeit further systematic research needed thoroughly understand biosafety issues biological effects prior clinical trials. synthesis often involves use strong acids temperatures, which, if not properly managed, can adverse on environment. Efforts should be made minimize release harmful byproducts ensure proper waste management during production process. In addition, it crucial assess into environment applications. For applications MOFs, several challenges exist. These include fabrication costs, poor selectivity, low capacity, quest stable water-resistant well difficulties recycling/regeneration maintaining chemical/thermal/mechanical stability. Thus, careful consideration associated with utilization vital. addition manufacturing processes, ultimate fate must taken account. While numerous reviews been published this perspective aims shed key issues, urging researchers conduct field. aspects biomedicine are discussed, focusing main outlining future directions.

Language: Английский

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