Recent advances in the use of graphitic carbon nitride-based composites for the electrochemical detection of hazardous contaminants

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 470, P. 214708 - 214708

Published: July 26, 2022

Language: Английский

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Iridium Complex with Specific Intercalation in the G-Quadruplex: A Phosphorescence and Electrochemiluminescence Dual-Mode Homogeneous Biosensor for Enzyme-Free and Label-Free Detection of MicroRNA

ACS Sensors, Journal Year: 2023, Volume and Issue: 8(4), P. 1529 - 1535

Published: March 24, 2023

Design and exploitation of high-property multifunctional emitters for achieving immobilization-free, label-free, enzyme-free, dual-mode determination microRNA (miRNA) with high sensitivity selectivity are particularly urgent but remain a huge challenge. Herein, the first time, we reported an Ir3+-based N-heterocyclic complex, namely, IrPyPt, ascertained its phosphorescence electrochemiluminescence (ECL) dual-emission behavior in homogeneous solution, discovered turn-up signal-off ECL response to G-quadruplex DNA over other DNAs. Inspired by this, IrPyPt was pioneered as emitter combine nucleic acid probes (ON1 ON2) developing biosensor, which applied highly sensitive, credible analysis miRNA-21 used target analyte. triggered hybridization chain reaction ON1 ON2 generate abundant G-quadruplexes, caught yield IrPyPt@G-quadruplex, intramolecular rotary motion inhibited unable diffuse electrode, contributing boosted emission sharply declined emission. With this design, achieved limits detection down 1.40 0.18 pM, respectively. Furthermore, biosensor triumphantly determine concentration cancer cell lysates thus provided great potential alternative miRNA-related diseases' early accurate diagnosis.

Language: Английский

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Nonenzymatic Sweat Wearable Uric Acid Sensor Based on N-Doped Reduced Graphene Oxide/Au Dual Aerogels

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(7), P. 3864 - 3872

Published: Feb. 6, 2023

Sweat wearable sensors enable noninvasive and real-time metabolite monitoring in human health management but lack accuracy applicability. The rational design of sensing electrode materials will be critical yet challenging. Herein, we report a dual aerogel-based nonenzymatic sensor for the sensitive selective detection uric acid (UA) sweat. three-dimensional porous dual-structural aerogels composed Au nanowires N-doped graphene nanosheets (noted as N-rGO/Au DAs) provide large active surface, abundant access to target, rapid electron transfer pathways, high intrinsic activity. Thus, direct UA electro-oxidation is demonstrated at DAs with much higher activity than those individual gels (i.e., N-rGO). Moreover, resulting chip displays performance good anti-interfering ability, long-term stability, excellent flexibility toward detection. With assistance wireless circuit, successfully applied on skin. obtained result comparable that evaluated by high-performance liquid chromatography. This biosensing platform not only holds considerable promise reliable sweat also opens an avenue metal-based flexible electrodes sensing.

Language: Английский

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Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 424 - 424

Published: March 27, 2023

Electrochemical biosensors are superior technologies that used to detect or sense biologically and environmentally significant analytes in a laboratory environment, even the form of portable handheld wearable electronics. Recently, imprinted implantable emerging as point-of-care devices, which monitor target continuous environment alert intended users anomalies. The stability performance developed biosensor depend on nature properties electrode material platform is constructed. Therefore, plays an integral role effectiveness biosensor. Enormous effort has been dedicated rational design fabrication strategies for improving biosensors. Every year, search multifarious materials, thousands new platforms reported. Moreover, order construct effectual biosensor, researcher should familiarize themself with sensible behind fabrication. Thus, we intend shed light various methodologies utilized electrochemical facilitate sensitive selective detection analytes. Furthermore, this review highlights advantages materials correlation between immobilized biomolecules modified surfaces.

Language: Английский

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Vertical growth of leaf-like Co-metal organic framework on carbon fiber cloth as integrated electrode for sensitive detection of dopamine and uric acid

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 386, P. 133734 - 133734

Published: March 27, 2023

Language: Английский

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Recent advancements of smartphone-based sensing technology for diagnosis, food safety analysis, and environmental monitoring

Talanta, Journal Year: 2024, Volume and Issue: 275, P. 126080 - 126080

Published: April 10, 2024

Language: Английский

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Magnetic graphene oxide and vertically-ordered mesoporous silica film for universal and sensitive homogeneous electrochemiluminescence aptasensor platform

Microchemical Journal, Journal Year: 2024, Volume and Issue: 200, P. 110315 - 110315

Published: March 12, 2024

Language: Английский

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CRISPR-Based Homogeneous Electrochemical Strategy for Near-Zero Background Detection of Breast Cancer Extracellular Vesicles via Fluidity-Enhanced Magnetic Capture Nanoprobe

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Precise identification and analysis of multiple protein biomarkers on the surface breast cancer cell-derived extracellular vesicles (BC-EVs) are great significance for noninvasive diagnosis subtypes, but it remains a major challenge owing to their high heterogeneity low abundance. Herein, we established CRISPR-based homogeneous electrochemical strategy near-zero background ultrasensitive detection BC-EVs. To realize high-performance capture isolation BC-EVs, fluidity-enhanced magnetic nanoprobes were facilely prepared. After capturing AND logic gate-based catalytic hairpin assembly (CHA) trans-cleavage activity CRISPR-Cas12a against signal triggered successively, generating significant signal. Notably, as-developed metal-mediated could efficiently decrease by separation, endowing method with signal-to-noise ratio. Consequently, ingeniously integrating DNA CRISPR-CHA amplification dual in strategy, precise BC-EVs was successfully achieved through simultaneous specific recognition markers surface. More importantly, this approach effectively discriminate subgroups clinical serum samples, which may provide opportunities accurate prognosis evaluation manner.

Language: Английский

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Recent Advances in Electrochemical and Optical Biosensors for Cancer Biomarker Detection

BioChip Journal, Journal Year: 2022, Volume and Issue: 17(1), P. 44 - 67

Published: Nov. 3, 2022

Language: Английский

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Directionally In Situ Self-Assembled Iridium(III)-Polyimine Complex-Encapsulated Metal–Organic Framework Two-Dimensional Nanosheet Electrode To Boost Electrochemiluminescence Sensing

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(32), P. 12024 - 12031

Published: Aug. 1, 2023

Manufacturing electrochemiluminescence (ECL) electrodes to detect analytes with high performance in the aqueous phase for water-insoluble metal complexes is a great challenge. Here, directional self-assembling avenue situ fabricating iridium(III)-polyimine complex-encapsulated metal-organic framework (MOF) two-dimensional electrode Hf-MOF/Ir2PD/APS/ITO developed. The displayed bright red ECL emission stability and specific adsorption toward ssDNA against dsDNA mNs. That say, "high-performance multifunctional electrode" presented explored sensitive detection of acetamiprid (Ace) limit 0.0025 nM, where Ace-aptamer recognition-switched Exonuclease III-mediated digestion make large numbers Fc-labeled transform into Fc-mNs. Furthermore, proposed method was triumphantly employed monitor change residual concentration Ace pakchoi. This work breaks through bottleneck complex-based organic solvents provides novel strategy develop high-performance sensors.

Language: Английский

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