Many
natural
products
(NPs)
exhibit
strong
antioxidant
activity,
making
them
valuable
for
various
applications.
In
this
context,
the
emergence
of
deep
eutectic
solvents
(DESs)
is
expected
to
help
address
growing
demand
innovative,
efficient,
and
more
sustainable
methods
NPs
extraction.
DESs
are
designer
that
provide
higher
yields
enhance
activity
extracted
phytochemicals
compared
with
conventional
volatile
organic
solvents.
Antioxidant
naturally
occurring
molecules
can
also
form
DESs,
either
as
hydrogen
bond
donors
(HBD)
or
acceptors
(HBA),
creating
DES
(NADES)
inherent
activity.
Thus,
containing
exert
synergistic
effects,
entire
system
a
promising
active
ingredient
food
industry
The
synergy
arises
from
enhanced
solubilization
stabilization
in
through
bonding,
ionic
interactions,
van
der
Waals
forces.
Collectively,
enable
effectively
neutralize
oxidants
(such
ROS
free
radicals)
regulate
their
reactions
other
molecules,
achieving
up
3-fold
increase
extracts
regular
vitro.
This
Account
overviews
wide
range
resources
using
DESs.
activities
HBA,
HBD,
along
advantageous
coupling
extracts,
thoroughly
discussed.
Finally,
we
envisage
future
directions
potential
applications
harnessing
collective
guide
advances
chemistry.
Foods,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1091 - 1091
Published: March 21, 2025
Resveratrol
is
the
most
important
biopotential
phytoalexin
of
stilbene
group
(natural
polyphenolic
secondary
metabolites),
synthesized
naturally
by
action
biotic
and
abiotic
factors
on
plant.
The
yield
individual
bioactive
compounds
isolated
from
grapevine
components,
products
by-products
directly
dependent
conditions
synthesis,
extraction
identification
techniques
used.
Modern
methods
synthesis
extraction,
as
well
techniques,
are
centred
use
non-toxic
solvents
that
have
advantages
realisation
rapid
extractions,
maintenance
optimal
parameters,
low
energy
consumption;
this
a
challenge
with
promising
results
for
various
industrial
applications.
Actionable
advances
in
identifying
analysing
stilbenes
consist
coupling
synthesis/extraction/identification
proven
accurate,
reproducible
efficient.
main
remains
to
keep
resveratrol
compositionally
unaltered
while
increasing
its
microbiome
solubility
stability
nutraceutical
food
industry.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5500 - 5500
Published: May 17, 2024
Various
studies
have
shown
that
Hypogymnia
physodes
are
a
source
of
many
biologically
active
compounds,
including
lichen
acids.
These
lichen-specific
compounds
characterized
by
antioxidant,
antiproliferative,
and
antimicrobial
properties,
they
can
be
used
in
the
cosmetic
pharmaceutical
industries.
The
main
aim
this
study
was
to
optimize
composition
natural
deep
eutectic
solvents
based
on
proline
or
betaine
lactic
acid
for
extraction
metabolites
from
H.
physodes.
design
experimental
method
response
surface
approach
allowed
optimization
process
specific
metabolites.
Based
preliminary
research,
multivariate
model
experiment
developed.
For
optimization,
following
parameters
were
employed
confirm
model:
proline/lactic
acid/water
molar
ratio
1:2:2.
Such
mixture
efficient
three
depsidones
(i.e.,
physodic
acid,
physodalic
3-hydroyphysodic
acid)
one
depside
atranorin).
developed
solvent
mixtures
ensured
good
efficiency
when
extracting
thallus
with
high
antioxidant
properties.
Foods,
Journal Year:
2024,
Volume and Issue:
13(18), P. 2863 - 2863
Published: Sept. 10, 2024
Using
natural
plant
extracts
as
food
additives
is
a
promising
approach
for
improving
products'
quality,
nutritional
value,
and
safety,
offering
advantages
both
consumers
the
environment.
Therefore,
main
goal
of
this
study
was
to
develop
sustainable
method
extracting
polyphenols
carotenoids
from
horned
melon
peel
using
cloud
point
extraction
(CPE)
technique,
intending
utilize
it
additive.
CPE
novel
separation
pre-concentration
different
compounds
while
being
simple,
inexpensive,
low-toxic.
Three
parameters
within
approach,
i.e.,
pH,
equilibrium
temperature,
time,
were
investigated
independent
variables
through
implementation
Box-Behnken
design
statistical
analyses.
The
optimized
conditions
maximum
recovery
carotenoids,
reaching
236.14
mg
GAE/100
g
13.80
β
carotene/100
g,
respectively,
pH
value
7.32,
an
temperature
55
°C,
time
43.03
min.
obtained
bioactives'
values
under
corresponded
predicted
ones,
indicating
suitability
employed
RSM
model.
These
results
highlight
effectiveness
in
bioactive
with
varying
polarities
agricultural
by-products,
underscoring
its
potential
enhancing
waste
advancing
practices
processing.
According
microbiological
safety
parameters,
optimal
extract
suitable
applications,
storage
refrigerated
dark
particularly
beneficial.
extract's
enhanced
stability
these
makes
more
viable
option
long-term
storage,
preserving
quality.
Many
natural
products
(NPs)
exhibit
strong
antioxidant
activity,
making
them
valuable
for
various
applications.
In
this
context,
the
emergence
of
deep
eutectic
solvents
(DESs)
is
expected
to
help
address
growing
demand
innovative,
efficient,
and
more
sustainable
methods
NPs
extraction.
DESs
are
designer
that
provide
higher
yields
enhance
activity
extracted
phytochemicals
compared
with
conventional
volatile
organic
solvents.
Antioxidant
naturally
occurring
molecules
can
also
form
DESs,
either
as
hydrogen
bond
donors
(HBD)
or
acceptors
(HBA),
creating
DES
(NADES)
inherent
activity.
Thus,
containing
exert
synergistic
effects,
entire
system
a
promising
active
ingredient
food
industry
The
synergy
arises
from
enhanced
solubilization
stabilization
in
through
bonding,
ionic
interactions,
van
der
Waals
forces.
Collectively,
enable
effectively
neutralize
oxidants
(such
ROS
free
radicals)
regulate
their
reactions
other
molecules,
achieving
up
3-fold
increase
extracts
regular
vitro.
This
Account
overviews
wide
range
resources
using
DESs.
activities
HBA,
HBD,
along
advantageous
coupling
extracts,
thoroughly
discussed.
Finally,
we
envisage
future
directions
potential
applications
harnessing
collective
guide
advances
chemistry.
