Advances in Preparation of Cyclodextrin‐Based Stimulus‐Responsive Carriers and Their Applications in Delivery of Functional Spices

Flavour and Fragrance Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

ABSTRACT Spices are substances that can be detected by the sense of smell or taste in their natural state. Currently, research on functional spices with properties such as anti‐tumour, vascularisation, anti‐inflammatory, and antibacterial effects attracts a lot attention. However, comprehensive reviews delivery systems remain limited. Among various carriers used for spice delivery, cyclodextrins widely applied due to unique properties, which feature hydrophobic interior hydrophilic exterior, particularly poorly soluble spices. In this study, representative mechanisms action introduced, then stimulus‐responsive cyclodextrin‐based summarised, applications field discussed. Furthermore, challenges faced future direction proposed promote construction an effective system.

Language: Английский

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Recent developments and applications of solid membrane in chiral separation

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1743, P. 465652 - 465652

Published: Jan. 2, 2025

Language: Английский

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Tailoring Chirality and Optimizing Enantioselective Recognition in Strategic Defect Engineering of Chiral Metal–Organic Frameworks

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Introducing chiral molecules into metal–organic frameworks (MOFs) to obtain MOFs (CMOFs), the tunability of their structures makes them a highly anticipated class materials for electrochemical sensing. However, structure CMOFs is often limited by synthesis challenges, and introducing leads decrease in internal space. This study introduces defect engineering strategy with defects, which an efficient method. The two constructed different not only have more recognition sites but also greatly increase substrate capacity due making wide range substrates enhancing enantioselective effect defective CMOFs. In addition, using MOF as carrier overcomes problem low conductivity molecules. Based on advantages CMOFs, we designed novel sensor excellent enantiomer performance. provides simple scalable synthetic method constructing defects high stability.

Language: Английский

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Chiral Separation of Mandelic Acid Derivatives Using Various Permethylated Cyclodextrin Selectors Containing Stationary Phases in GC

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 451 - 451

Published: Jan. 21, 2025

A good chiral separation usually results in a trial-and-error process; however, through systematic studies, certain principles can be established to correlate structure with selectivity. These then applied other separations, reducing the time of developing selective analytical methods. Using model compounds, wider range compounds. In this study, mandelic acid and its substituted derivatives were selected as compounds establish transferable rules. The selectivity 13 was measured on various permethylated cyclodextrin selectors. Comparing cyclodextrins different ring sizes (α, β, γ) provides further insight into role inclusion cyclodextrin-based stationary phases. Different acidic hydroxyl functions acids tested. Ring- alkyl-substituted enantiomeric pairs also By using these hydrogen donor–acceptor interactions dipole–dipole inclusions recognition processes investigated. values extrapolated same temperature, for sake comparison. Several general tendencies concluded, which used enantiomer pairs.

Language: Английский

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CHIRAL ANALYSIS BY CAPILLARY ELECTROMIGRATION TECHNIQUES

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118256 - 118256

Published: April 1, 2025

Language: Английский

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Enantioseparation of Mirabegron Using Cyclodextrin‐based Chiral Columns: High‐performance Liquid Chromatography and Molecular Modeling Study

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(4)

Published: April 1, 2025

ABSTRACT A novel high‐performance liquid chromatography method for the enantioseparation of mirabegron ( R ‐mirabegron), a selective β‐3 adrenergic receptor agonist, using cyclodextrin (CD)‐based chiral stationary phases (CSPs) was developed. Seven different CSPs containing β‐, γ‐, hydroxypropyl‐β‐, sulfobutyl‐β‐, carboxymethyl‐β‐, permethyl‐β‐, and phenylcarbamate‐β‐cyclodextrin were evaluated under both polar organic reversed‐phase conditions. Only Chiral CD‐Ph column displayed enantiorecognition. Optimization conditions full factorial design led to determination most suitable conditions: mobile phase composition 90:10:0.1 methanol:water:diethylamine, flow rate 0.8 mL/min, temperature 40°C with enantiomeric elution order, where impurity S ‐mirabegron elutes first. Using optimized conditions, s = 1.9 achieved within 10 min. The developed validated according current guidelines successfully applied ‐mirabegron, as in pharmaceutical formulations. enantiorecognition mechanism investigated by molecular docking thermodynamic analysis. modeling, interactions between CDs analyte analyzed at level, revealing that interacts primarily phenylcarbamate groups on outer surface structure. Enthalpy‐controlled consistently observed across all eluent compositions, regardless is highly routine purity mirabegron, offering reliable tool regulatory compliance.

Language: Английский

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Multi-Interaction (Substituted-Phenylcarbamate)-Hydroxypropyl-β-Cyclodextrin Chiral Stationary Phases for Liquid Chromatography

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 344104 - 344104

Published: April 1, 2025

Language: Английский

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Review of Applications of β-Cyclodextrin as a Chiral Selector for Effective Enantioseparation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10126 - 10126

Published: Sept. 20, 2024

The significance and necessity of separating enantiomers in food, pharmaceuticals, pesticides, other samples remains constant unrelenting. successful chiral separation usually includes the application a auxiliary compound, known also as selector (CS), that forms complexes with different physicochemical properties, enabling efficient separation. While both native substituted cyclodextrins (CDs) are commonly used CSs, β-CD is undoubtedly most popular one among them. This review recent advancements CS. theoretical background behind enantioseparation part this work, main emphasis put on factors affect efficacy process such temperature, pH, solvent, choice additives. Also, analytical methods: Nuclear Magnetic Resonance (NMR) spectroscopy, Capillary Electrophoresis (CE), fluorescence spectroscopy (FS), High-Performance Liquid Chromatography (HPLC), Isothermal Titration Calorimetry (ITC), UV–vis for aid CS, thoroughly compared. since some compounds have been studied context their more than once, those works compared critically analyzed. In conclusion, while can be cases experimental conditions method analysis crucial to achieve success.

Language: Английский

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Sustainable solutions for direct TLC enantioseparation with in‐home thought‐out, prepared/modified chiral stationary phases

Biomedical Chromatography, Journal Year: 2024, Volume and Issue: 38(12)

Published: Sept. 24, 2024

Abstract TLC is used globally, yet less attention has been paid to (in enantioseparation) despite its advantages. The present paper describes/reviews successfully practiced direct approaches of ‘chiral additive in achiral stationary phase’ (as an application in‐home thought out , prepared, tested, and modified chiral phase), ‘pre‐mixing reagent with the enantiomeric mixture’ (an approach using both phases during chromatographic separation) mobile phase’, ligand exchange for enantioseparation DL‐amino acids, their derivatives, some active pharmaceutical ingredients. It provided efficient enantioseparation, quantitative determination, isolation native forms via in‐situ formation non‐covalent diastereomeric pair. mechanism these discussed along establishment structure diastereomers. This may help chemists gain useful insights into fields outside specialization experts get brief accounts recent key developments, providing solutions sustainable development expensive methods control purity enantiomers.

Language: Английский

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Synthesis of Novel High-Performance All-Biobased Wood Flame Retardant Materials Using Phytic Acid and Β-Cyclodextrin

Published: Jan. 1, 2024

Language: Английский

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