ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 9, 2024
The
phytochemical
investigation
of
the
whole
plants
Coelogyne
fuscescens
Lindl.
var.
brunnea
led
to
discovery
three
new
phenolic
glycosides,
i.e.,
coelofusides
A–C
(1–3)
and
12
known
compounds
(4–15).
For
first
time,
we
reported
nuclear
magnetic
resonance
(NMR)
data
4-O-(6′-O-glucosyl-4″-hydroxybenzoyl)-4-hydroxybenzyl
alcohol
(4)
in
this
study.
identification
structures
newly
discovered
was
done
through
analysis
their
spectroscopic
[NMR,
mass
spectrometry,
ultraviolet,
Fourier
transform
infrared,
optical
rotation,
circular
dichroism
(CD)].
In
comparison
anticancer
drugs
(i.e.,
etoposide
carboplatin),
evaluated
potential
isolated
on
two
different
breast
cancer
cell
lines,
namely,
T47D
MDA-MB-231.
Human
fibroblast
HaCaT
cells
were
used
as
control
cells.
After
a
48
h
incubation,
flavidin
(8),
coelonin
(10),
3,4-dihydroxybenzaldehyde
(11),
oxoflavidin
(12)
showed
significant
cytotoxic
effects
against
Among
them,
exhibited
most
potent
cytotoxicity
MDA-MB-231
with
an
IC50
value
26.26
±
4.33
μM.
staining
assay,
induced
apoptosis
after
both
dose-dependent
manner.
Furthermore,
upregulated
expression
apoptotic
genes,
such
p53,
Bax,
poly(ADP-ribose)
polymerase,
caspase-3,
caspase-9
genes
while
significantly
decreasing
antiapoptotic
protein
(Bcl-2)
levels.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(9), P. 1531 - 1531
Published: May 2, 2023
Flavonoids
are
polyphenolic
compounds
widely
occurring
throughout
the
plant
kingdom.
They
biologically
active
and
have
many
medical
applications.
reveal
chemopreventive,
anticarcinogenic,
antioxidant
properties,
as
well
being
able
to
modulate
immune
system
response
inhibit
inflammation,
angiogenesis,
metastasis.
Polyphenols
also
believed
reverse
multidrug
resistance
via
various
mechanisms,
induce
apoptosis,
activate
cell
death
signals
in
tumor
cells
by
modulating
signaling
pathways.
The
main
limitation
broader
usage
of
flavonoids
is
their
low
solubility,
poor
absorption,
rapid
metabolism.
To
tackle
this,
combining
with
nanocarriers
could
improve
bioavailability
create
systems
wider
functionalities.
Recently,
interest
hybrid
materials
based
on
combinations
metal
nanoparticles
has
increased
due
unique
physicochemical
biological
including
improved
selectivity
toward
target
sites.
In
addition,
further
utilities,
even
initial
step
preparation
nanomaterials.
review
offers
knowledge
multiple
possibilities
synthesis
flavonoid-metal
nanoparticle
conjugates,
presents
some
features
such
size,
shape,
surface
charge,
stability.
discussed
regarding
properties
potential
Compounds,
Journal Year:
2024,
Volume and Issue:
4(2), P. 214 - 229
Published: March 22, 2024
Distributed
throughout
the
environment
are
various
microorganisms
such
as
bacteria,
fungi,
parasites,
and
viruses.
Although
many
part
of
human
microbiome,
pathogenic
cause
infections
ranging
from
mild
to
severe.
In
recent
years,
identification
multidrug-resistant
has
become
a
serious
public
health
problem.
The
resulting
call
into
question
therapeutic
capacity
systems
lead
approximately
70,000
deaths
annually
worldwide.
progressive
resistance
antibiotics
antifungals
been
major
challenge
for
medical
pharmaceutical
community,
requiring
search
new
compounds
with
antimicrobial
properties.
Several
studies
have
demonstrated
potential
natural
synthesized
flavonoids,
especially
dimers
these
molecules.
this
review
presented
examples
dimeric
flavonoids
that
activity
against
viruses,
like
influenza
Human
Immunodeficiency
Virus
(HIV),
protozoal
infections,
Leishmaniasis
Malaria,
fungal
by
Candida
albicans
Cryptococcus
neoformans,
bacterial
caused,
example,
Staphylococcus
aureus
Escherichia
coli.
pursuit
find
safe
agents
therapy
in
microbial
an
option
not
only
activity,
but
also
low
toxicity
usually
associated
when
compared
classic
antimicrobials.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(4), P. 605 - 605
Published: April 17, 2023
Cancer
is
a
complex
and
multifaceted
group
of
diseases
characterized
by
the
uncontrolled
growth
spread
abnormal
cells.
While
cancer
can
be
challenging
life-altering,
advances
in
research
development
have
led
to
identification
new
promising
anti-cancer
targets.
Telomerase
one
such
target
that
overexpressed
almost
all
cells
plays
critical
role
maintaining
telomere
length,
which
essential
for
cell
proliferation
survival.
Inhibiting
telomerase
activity
lead
shortening
eventual
death,
thus
presenting
itself
as
potential
therapy.
Naturally
occurring
flavonoids
are
class
compounds
already
been
shown
possess
different
biological
properties,
including
property.
They
present
various
everyday
food
sources
richly
fruits,
nuts,
soybeans,
vegetables,
tea,
wine,
berries,
name
few.
Thus,
these
could
inhibit
or
deactivate
expression
mechanisms,
include
inhibiting
hTERT,
mRNA,
protein,
nuclear
translocation,
binding
transcription
factors
hTERT
promoters,
even
shortening.
Numerous
line
studies
vivo
experiments
supported
this
hypothesis,
serve
vital
innovative
therapeutic
option
cancer.
In
light,
we
aim
elucidate
target.
Subsequently,
illustrated
how
commonly
found
natural
demonstrate
their
via
inactivation
types,
proving
naturally
useful
agents.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5409 - 5409
Published: Nov. 16, 2024
Overexposure
to
ultraviolet
radiation
mainly
leads
skin
disorders
(erythema,
burns,
immunosuppression),
aging,
and
cancer
as
the
most
serious
side
effect.
It
has
been
widely
accepted
that
using
sunscreen
products
is
an
important
way
protect
against
harmful
effects
of
UV
rays.
Although
commercial
sunscreens
have
constantly
changed
improved
over
time,
there
are
emerging
concerns
about
safety
conventional,
organic,
filters
due
adverse
on
humans
(such
photoallergic
dermatitis,
contact
sensitivity,
endocrine-disrupting
effects,
etc.)
well
accumulation
in
environment
aquatic
organisms.
This
why
natural
compounds
increasingly
being
investigated
used
cosmetic
pharmaceutical
sunscreens.
Some
these
available,
non-toxic,
safer
for
use,
considerable
protective
properties
less
effects.
Plant-based
such
flavonoids
can
absorb
UVA
UVB
rays
possess
antioxidant,
anticarcinogenic,
anti-inflammatory
contribute
photoprotection.
Apart
from
flavonoids,
other
certain
vegetable
oils,
carotenoids,
stilbenes,
ferulic
acid
also
UV-absorbing
properties.
vitamins
might
be
beneficial
protection
their
antioxidant
activity.
Therefore,
aim
this
research
was
gain
insight
into
potential
replace
or
reduce
amount
conventional
filters,
based
recent
research.
Plants,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1772 - 1772
Published: April 26, 2023
Currently,
much
effort
is
being
placed
into
obtaining
extracts
and/or
essential
oils
from
Cannabis
sativa
L.
for
specific
therapeutic
purposes
or
pharmacological
compositions.
These
potential
applications
depend
mainly
on
the
phytochemical
composition
of
oils,
which
in
turn
are
determined
by
type
C.
and
extraction
method
used
to
obtain
oils.
In
this
work,
we
have
evaluated
contents
secondary
metabolites,
delta-9-tetrahydrocannabinol
(THC),
cannabidiol
(CBD),
addition
total
phenolic,
flavonoids,
anthraquinone
content
obtained
using
solid-liquid
(SLE)
supercritical
fluid
(SCF).
Different
varieties
were
chosen
ratio
THC
CBD
concentrations.
Additionally,
antioxidant,
antifungal
anticancer
activities
different
cancer
cell
lines
vitro.
The
results
indicate
that
extracted
SLE,
with
high
CBD,
phenolic
compounds,
exhibit
a
antioxidant
capacity
induce
decrease
viability
tested
breast
line
(MCF-7).
observed
biological
attributed
entourage
effect,
phenols
flavonoids
play
key
role.
Therefore,
it
concluded
right
selection
variety
solvent
SLE
could
be
optimal
oil
develop
natural
agent.
