Eco-friendly green synthesis of silver nanoparticles from guajava leaves extract for controlling organophosphorus pesticides hazards, characterization, and in-vivo toxicity assessment DOI Creative Commons
Emad Ali Albadawi,

Eleonora Musa,

Hadel Mahroos Ghaban

et al.

BMC Pharmacology and Toxicology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 18, 2024

Abstract This study explores an eco-friendly approach to mitigate risks associated with organophosphorus insecticides, particularly Chlorpyrifos, by synthesizing silver nanoparticles (AgNPs) using Psidium guajava leaf extract and preparing a nanocomposite (AgNPs/S18) Chlorpyrifos pesticide. The green-synthesized AgNPs AgNPs/S18 were characterized various analytical techniques, confirming the successful synthesis of average size 37 nm forming stable nanocomposite. Antibacterial assays demonstrated significant activity against Staphylococcus aureus, showing 87.8% reduction achieving 72% in bacterial population. Cytotoxicity evaluations on normal liver cancer cell lines revealed enhanced cytotoxicity compared alone, suggesting potential applications targeted therapies. In vivo studies rats protective effects Chlorpyrifos-induced toxicity kidney tissues. Histopathological ultrastructural analyses showed both treatments, nanocomposite, significantly mitigated cellular damage caused exposure. These findings suggest that their offer promising reducing pesticide hazards while maintaining efficacy. research contributes developing safer alternatives pest management, addressing need for more environmentally friendly agricultural practices protecting human health ecosystems.

Language: Английский

Flavonoids: Overview of Biosynthesis, Biological Activity, and Current Extraction Techniques DOI Creative Commons
Sergio Liga, Cristina Paul, Fráncisc Péter

et al.

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2732 - 2732

Published: July 23, 2023

Recently, increased attention has been paid to natural sources as raw materials for the development of new added-value products. Flavonoids are a large family polyphenols which include several classes based on their basic structure: flavanones, flavones, isoflavones, flavonols, flavanols, and anthocyanins. They have multitude biological properties, such anti-inflammatory, antioxidant, antiviral, antimicrobial, anticancer, cardioprotective, neuroprotective effects. Current trends research flavonoids relate identification, extraction, isolation, physico-chemical characterization, applications health benefits. This review presents an up-to-date survey most recent developments in flavonoid classes, activity representative flavonoids, current extraction techniques, perspectives.

Language: Английский

Citations

115
Current Overview of Metal Nanoparticles’ Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles DOI Creative Commons
Ana Flavia Burlec, Andreia Corciovă, Monica Boev

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1410 - 1410

Published: Oct. 4, 2023

Metal nanoparticles (NPs) have garnered considerable attention, due to their unique physicochemical properties, that render them promising candidates for various applications in medicine and industry. This article offers a comprehensive overview of the most recent advancements manufacturing, characterization, biomedical utilization metal NPs, with primary focus on silver gold NPs. Their potential as effective anticancer, anti-inflammatory, antimicrobial agents, drug delivery systems, imaging agents diagnosis treatment variety disorders is reviewed. Moreover, translation therapeutic settings, issue inclusion clinical trials, are assessed light over 30 investigations concentrate administering either or NPs conditions ranging from nosocomial infections different types cancers. paper aims not only examine biocompatibility nanomaterials but also emphasize challenges may limit safe integration into healthcare practices. More than 100 nanomedicines currently market, which justifies ongoing study use medicine. Overall, present review highlight innovative therapeutics field biomedicine, citing some relevant current applications.

Language: Английский

Citations

91
A Comprehensive Review of Free Radicals, Oxidative Stress, and Antioxidants: Overview, Clinical Applications, Global Perspectives, Future Directions, and Mechanisms of Antioxidant Activity of Flavonoid Compounds DOI Creative Commons
Sefren Geiner Tumilaar, Ari Hardianto, Hirofumi Dohi

et al.

Journal of Chemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 21

Published: May 31, 2024

Absorption​ of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.

Language: Английский

Citations

38
Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine DOI Creative Commons
M. Zahra, Heidi Abrahamse, Blassan P. George

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 922 - 922

Published: July 29, 2024

This study emphasizes the critical role of antioxidants in protecting human health by counteracting detrimental effects oxidative stress induced free radicals. Antioxidants-found various forms such as vitamins, minerals, and phytochemicals abundant fruits vegetables-neutralize radicals stabilizing them through electron donation. Specifically, flavonoid compounds are highlighted robust defenders, addressing inflammation to avert chronic illnesses like cancer, cardiovascular diseases, neurodegenerative diseases. research explores bioactive potential flavonoids, shedding light on their not only safeguarding health, but also managing conditions diabetes, review highlights novel integration South African-origin flavonoids with nanotechnology, presenting a cutting-edge strategy improve drug delivery therapeutic outcomes. interdisciplinary approach, blending traditional wisdom contemporary techniques, propels exploration flavonoid-mediated nanoparticles toward groundbreaking pharmaceutical applications, promising revolutionary advancements healthcare. collaborative synergy between knowledge modern science contributes underscores significant step sustainable impactful biomedical innovations, aligning principles environmental conservation.

Language: Английский

Citations

28
Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management DOI
Jinjin Pei,

Ranil Vikraman Kumarasamy,

Selvaraj Jayaraman

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665

Published: Jan. 1, 2025

Language: Английский

Citations

8
Rutin-coated zinc oxide nanoparticles: a promising antivirulence formulation against pathogenic bacteria DOI

Fatemeh Azizi Alidoust,

Behnam Rasti, Hojjatolah Zamani

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(6)

Published: April 29, 2024

Language: Английский

Citations

9
Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review DOI Creative Commons
Mohamed T. El‐Saadony, Guihong Fang, Si Yan

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12889 - 12937

Published: Dec. 1, 2024

Abstract: Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, drug/gene delivery. Among these, zinc (ZnO) NPs stand out versatility effectiveness. Recently, ZnO become a primary material various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, automotive industries. can generate reactive oxygen species induce cellular apoptosis, thus underpinning potent anticancer antibacterial properties. To meet growing demand, numerous synthetic approaches been developed produce NPs. However, traditional manufacturing processes often involve economic environmental costs, prompting search more sustainable alternatives. Intriguingly, synthesis methods utilizing plants, plant extracts, or microorganisms emerged ideal producing These green production techniques offer medicinal, economic, environmental, health benefits. This review highlights latest advancements applications, showcasing potential revolutionize field with eco-friendly cost-effective solutions. Keywords: antimicrobial, antioxidant, synthesis, nanomedicine, nanoparticle,

Language: Английский

Citations

9
Green synthesis of iron oxide nanoparticles using Thymus migricus for multifunctional applications in antioxidant, antimicrobial, photocatalytic, and seed priming processes DOI Creative Commons
Sanaz Ashrafi-Saiedlou, MirHassan Rasouli-Sadaghiani, Mohammad Reza Fattahi

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42933 - e42933

Published: Feb. 1, 2025

Language: Английский

Citations

1
Preparation of dandelion flower extract-based polyvinyl alcohol-chitosan-dandelion-CuNPs composite gel for efficient bacteriostatic and dye adsorption DOI
Yueqi Wang, Tingting Zhang, Mei-Zi Huang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136512 - 136512

Published: Oct. 13, 2024

Language: Английский

Citations

5
Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis DOI Creative Commons

Jiazhe Du,

Yincang Wang,

Chengliang Wu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 2, 2024

Osteoporosis is a systemic metabolic disease characterized by disrupted bone formation/resorption and homeostasis. Flavonoids extracted from traditional Chinese medicinal plants regulate homeostasis intervening in differentiating marrow mesenchymal stem cells, balancing the immune system, inhibiting oxidative stress response, reversing iron overload. The target molecules signaling pathways, such as Wnt/β-catenin OPG/RANKL/RANK, directly affect osteoblast/osteoclast activity, exhibiting significant potential treatment of OP. Therefore, this study presents systematic review recent literature to provide comprehensive information on medicine flavonoids involved regulation Also, molecular mechanisms pharmacological uses these metabolites are summarized, their clinical translation development discussed.

Language: Английский

Citations

4