Texture analysis can predict response to etoposide-doxorubicin-cisplatin in patients with adrenocortical carcinoma DOI Creative Commons
Filippo Crimì,

F Turatto,

Carlo D’Alessandro

et al.

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Abstract Background The adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy originating from the adrenal cortex. These patients usually undergo chemotherapy with etoposide, doxorubicin, cisplatin mitotane (EDP-M) in case of locally advanced or metastatic ACC. Computed tomography (CT) radiomics showed to be useful pathologies. study aimed analyze association between response EDP-M treatment CT textural features at diagnosis ACCs. Methods We enrolled 17 ACC who underwent before after therapy. was evaluated according RECIST 1.1, Choi, volumetric criteria. Based on aforementioned criteria, were classified as responders not responders. Textural extracted biggest lesion contrast-enhanced images LifeX software. ROC curves drawn for variables that significantly different ( p < 0.05) two groups. Results Long-run high grey level emphasis (LRHGLE_GLRLM) histogram kurtosis responder groups = 0.04) multivariate curve combining very good AUC (0.900; 95%IC: 0.724-1.000) discriminating More heterogeneous tissue texture initial staging could predict positive treatment. Conclusions Adrenal able therapy

Language: Английский

Probing Single-Cell Adhesion Kinetics and Nanomechanical Force with Surface Plasmon Resonance Imaging DOI
Dehong Yang, Xiaoyin Liu, Jinbiao Ma

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Single cell adhesion plays a significant role in numerous physiological and pathological processes. Real-time imaging quantification of single kinetics corresponding cell–substrate mechanical interaction forces are crucial for elucidating the cellular mechanisms involved tissue formation, immune responses, cancer metastasis. Here, we present development plasmonic-based nanomechanical sensing system (PNMSi) real-time measurement associated with plasmonic tracking monitoring interactions accompanying nanoscale fluctuations. Both slow binding dynamic processes were tracked analyzed thermodynamic model to determine kinetic parameters quantity forces. To demonstrate capabilities PNMSi platform, examined across four different surface modifications, obvious alterations observed, influenced by charges interfacial hydrophilicity. Additionally, investigated changes cells during cytoskeleton modification, revealing cross-linking-induced changes. Furthermore, application capability system, profiling primary tumor metastatic was explored, observed interaction. The platform facilitates high-throughput high sensitivity serves as promising identifying biomarkers metastasis screening potential therapeutic agents.

Language: Английский

Citations

1
Mitochondrial signaling pathways and their role in cancer drug resistance DOI
Ashwani Sharma, Tarun Virmani, Girish Kumar

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329

Published: Aug. 5, 2024

Language: Английский

Citations

8
Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets DOI Creative Commons
Xiangpeng Wang,

Xiaoxia Xue,

Mingshi Pang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: Aug. 1, 2024

Abstract Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal (EMP). cells with EMP manifest in three states as transition (EMT), partial EMT, mesenchymal–epithelial transition, orchestrate switch heterogeneity tumor via transcriptional regulation series signaling pathways, transforming growth factor‐β, Wnt/β‐catenin, Notch. However, due complicated nature EMP, diverse process not fully understood. In this review, we systematically conclude biological background, regulating mechanisms well role therapy response. We also summarize range small molecule inhibitors, immune‐related approaches, combination therapies that have been developed target for outstanding EMP‐driven deterioration. Additionally, explore potential technique EMP‐based mechanistic investigation research, may burst vigorous prospects. Overall, elucidate multifaceted aspects progression suggest promising direction treatment based on targeting EMP.

Language: Английский

Citations

4
Living in a noisy world—origins of gene expression noise and its impact on cellular decision‐making DOI Open Access
Sampriti Pal, Riddhiman Dhar

FEBS Letters, Journal Year: 2024, Volume and Issue: 598(14), P. 1673 - 1691

Published: May 9, 2024

The expression level of a gene can vary between genetically identical cells under the same environmental condition—a phenomenon referred to as noise. Several studies have now elucidated central role transcription factors in generation Transcription factors, key components regulatory networks, drive many important cellular decisions response and signals. Therefore, very relevant question is how noise impacts regulation influences decision‐making. In this Review, we summarize current understanding molecular origins noise, highlighting process, discuss ways which influence As advances single‐cell technologies open new avenues for studying well circuits, better on will implications biological processes.

Language: Английский

Citations

3
Esterase-responsive nanoparticles (ERN): A targeted approach for drug/gene delivery exploits DOI

Ashok Kumar Madikonda,

Amritha Ajayakumar,

Sudeena Nadendla

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 116, P. 118001 - 118001

Published: Nov. 14, 2024

Language: Английский

Citations

2
Texture analysis can predict response to etoposide-doxorubicin-cisplatin in patients with adrenocortical carcinoma DOI Creative Commons
Filippo Crimì,

F Turatto,

Carlo D’Alessandro

et al.

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 9, 2024

Abstract Background The adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy originating from the adrenal cortex. These patients usually undergo chemotherapy with etoposide, doxorubicin, cisplatin mitotane (EDP-M) in case of locally advanced or metastatic ACC. Computed tomography (CT) radiomics showed to be useful pathologies. study aimed analyze association between response EDP-M treatment CT textural features at diagnosis ACCs. Methods We enrolled 17 ACC who underwent before after therapy. was evaluated according RECIST 1.1, Choi, volumetric criteria. Based on aforementioned criteria, were classified as responders not responders. Textural extracted biggest lesion contrast-enhanced images LifeX software. ROC curves drawn for variables that significantly different ( p < 0.05) two groups. Results Long-run high grey level emphasis (LRHGLE_GLRLM) histogram kurtosis responder groups = 0.04) multivariate curve combining very good AUC (0.900; 95%IC: 0.724-1.000) discriminating More heterogeneous tissue texture initial staging could predict positive treatment. Conclusions Adrenal able therapy

Language: Английский

Citations

0