Application of Biomechanics in Tumor Epigenetic Research DOI Creative Commons
Qi Wang, Xiaohong Yin,

Yunyi Ding

et al.

Mechanobiology in Medicine, Journal Year: 2024, Volume and Issue: 2(4), P. 100093 - 100093

Published: Aug. 23, 2024

Language: Английский

Matrix stiffness affects tumor-associated macrophage functional polarization and its potential in tumor therapy DOI Creative Commons
Jiaqiang Xiong, Rourou Xiao, Jiahui Zhao

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 21, 2024

The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) function is regulated by stiffness solid tumors often associated with poor prognosis. ECM stiffness-induced mechanical cues can activate cell membrane mechanoreceptors corresponding mechanotransducers the cytoplasm, modulating phenotype of TAMs. Currently, tuning TAM polarization through stimulation has received increasing attention, whereas its effect on fate rarely been summarized. A better understanding relationship between will contribute to development new strategies for cancer therapy. In this review, we first introduced overall stiffness, analyzed changes mediated tumor progression, finally summarized effects targeting prognosis provide insight into field.

Language: Английский

Citations

20
Probing the physical hallmarks of cancer DOI
Hadi T. Nia, Lance L. Munn, Rakesh K. Jain

et al.

Nature Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

1
Deciphering permissivity of human tumor ecosystems to oncolytic viruses DOI Creative Commons
Benjamin Schoeps, Ulrich M. Lauer,

Knut Elbers

et al.

Oncogene, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Effective cancer therapy involves initiation of a tumor-specific immune response. Consequently, the interest in oncolytic viruses (OV) capable triggering immunogenic cell death has sparked recent years. However, common use pre-clinical models that fail to mirror patient tumor ecosystems (TES) hinders clinical translation. Here, we provide condensed view on intricate interplay between several aspects TES and OV action discuss these considerations recently developed human model systems. Given urgent demand for innovative treatments, purpose this review is highlight so-far overlooked complex impact microenvironment (TME) permissivity, with intent foundation future, more effective studies.

Language: Английский

Citations

1
Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation DOI

Paras Famta,

Saurabh Shah,

Ganesh Vambhurkar

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 15(2), P. 389 - 406

Published: July 15, 2024

Language: Английский

Citations

5
Focus on mechano-immunology: new direction in cancer treatment DOI Creative Commons
Lin Zhao,

Yajun Gui,

Xiangying Deng

et al.

International Journal of Surgery, Journal Year: 2025, Volume and Issue: 111(3), P. 2590 - 2602

Published: Jan. 7, 2025

The immune response is modulated by a diverse array of signals within the tissue microenvironment, encompassing biochemical factors, mechanical forces, and pressures from adjacent tissues. Furthermore, extracellular matrix its constituents significantly influence function cells. In case carcinogenesis, changes in biophysical properties tissues can impact received cells, these c1an be translated into through mechano-transduction pathways. These pathways have profound on cellular functions, influencing processes such as cell activation, metabolism, proliferation, migration, etc. Tissue mechanics may undergo temporal during process offering potential for novel dynamic levels regulation. Here, we review advances mechanoimmunology malignancy studies, focusing how mechanosignals modulate behaviors cells at level, thereby triggering an that ultimately influences development progression malignant tumors. Additionally, also focused mechano-immunoengineering systems, with help which could to further understand tumor or alterations microenvironment provide new research directions overcoming immunotherapeutic resistance

Language: Английский

Citations

0
Beyond the tumor region: Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer DOI

Zhiying Liang,

Ming‐Lung Yu, Hui Yang

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(8)

Published: Jan. 23, 2025

BACKGROUND The peritumoral region possesses attributes that promote cancer growth and progression. However, the potential prognostic biomarkers in this remain relatively underexplored radiomics. AIM To investigate value importance of radiomics locally advanced rectal (LARC). METHODS This retrospective study included 409 patients with biopsy-confirmed LARC treated neoadjuvant chemoradiotherapy surgically. Patients were divided into training (n = 273) validation 136) sets. Based on intratumoral radiomic features extracted from pretreatment axial high-resolution small-field-of-view T2-weighted images, multivariate Cox models for progression-free survival (PFS) prediction developed or without clinicoradiological evaluated Harrell’s concordance index (C-index), calibration curve, decision curve analyses. Risk stratification, Kaplan-Meier analysis, permutation feature analysis performed. RESULTS comprehensive integrated clinical-radiological-omics model (ModelICRO) integrating seven peritumoral, three intratumoral, four achieved highest C-indices (0.836 0.801 sets, respectively). showed robust better clinical net benefits, effectively distinguished high-risk low-risk (PFS: 97.2% vs 67.6% 95.4% 64.8% respectively; both P < 0.001). Three most influential predictors ModelICRO were, order, a an feature. Notably, outperformed (C-index: 0.754 0.670; 0.015); significantly enhanced performance based their combinations. CONCLUSION Peritumoral holds greater than predicting PFS LARC. may serve as reliable tool stratification management postoperatively.

Language: Английский

Citations

0
Mechanical forces and enzymatic digestion act together to induce the remodeling of collagen fibrils in tumor microenvironment DOI
Jie Shi,

Aihua Jing,

Qinan Yin

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A microfluidic chip-based collagen fibril tissue model was established to investigate the formation of orientation fibrils in a tumor micro-environment.

Language: Английский

Citations

0
Malignant Cells Beyond the Tumor Core: The Non‐Negligible Factor to Overcome the Refractory of Glioblastoma DOI Creative Commons

Yaou Zhou,

Qi-Lin He,

Guanglong Huang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

ABSTRACT Background Glioblastoma (GBM) is one of the most aggressive primary brain tumors in adults. Over 95% GBM patients experience recurrence peritumoral tissue or distant regions, indicating presence critical factors these areas that drive tumor recurrence. Current clinical treatments primarily focus on cells from core (TC), while role neoplastic beyond TC has been largely neglected. Methods We conducted a comprehensive review existing literature and studies GBM, focusing identification characterization questionable (Q cells). Advanced imaging techniques, such as diffusion tensor (DTI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), were utilized to identify Q core. also analyzed functional properties, cellular microenvironment, physical characteristics cells, well their implications for surgical resection. Results Our revealed exhibit unique attributes, including enhanced invasiveness, metabolic adaptations, resistance mechanisms. These reside distinct microenvironment are influenced by properties solid stress stiffness. techniques have improved enabling more precise Targeting therapeutic strategies could significantly reduce risk Conclusion The zone (PBZ) factor treatments, which target TC, insufficient prevent due neglect cells. Future research should understanding mechanisms influencing developing targeted therapies improve patient outcomes.

Language: Английский

Citations

0
Crystal ribcage: a platform for probing real-time lung function at cellular resolution DOI
Rohin Banerji,

Gabrielle N. Grifno,

Linzheng Shi

et al.

Nature Methods, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 14, 2023

Language: Английский

Citations

10
Deep learning model targeting cancer surrounding tissues for accurate cancer diagnosis based on histopathological images DOI Creative Commons
Lanlan Li,

Yi Geng,

Tao Chen

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Accurate and fast histological diagnosis of cancers is crucial for successful treatment. The deep learning-based approaches have assisted pathologists in efficient cancer diagnosis. remodeled microenvironment field cancerization may enable the cancer-specific features image non-cancer regions surrounding cancer, which provide additional information not available region to improve Here, we proposed a learning framework with fine-tuning target proportion towards tissues images gastric Through employing six models targeting region-of-interest (ROI) different proportions no-cancer regions, uncovered diagnostic value ROI, model performance depended on proportion. Then, constructed based MobileNetV2 optimized weights ROI diagnose (DeepNCCNet). In external validation, DeepNCCNet demonstrated excellent generalization abilities an accuracy 93.96%. conclusion, discovered weight-dependent performance, indicating potential cancerization, provides promising resource could be readily applied clinical useful some settings such as absence or minimum amount tumor insufficient biopsy.

Language: Английский

Citations

0