Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2125 - 2126
Published: July 11, 2024
Language: Английский
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 19, 2024
Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within tumor microenvironment (TME) have deepened our understanding of mechanisms behind treatment resistance. Therefore, this review aims to synthesize current research focusing on infiltrating cells and drug suggesting that targeting TME could be viable strategy combat issue. Numerous factors, including inflammation, metabolism, senescence, hypoxia, angiogenesis, contribute Overexpression STAT3 is commonly associated with drug-resistant or stromal cells. Current often generalizes impact resistance, lacking specificity statistical robustness. Thus, future should take notice issue aim provide high-quality evidence. Despite existing limitations, overcome therapy hold promising valuable potential.
Language: Английский
Citations
11
Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: March 12, 2025
Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway plays a crucial role in activating innate and specific immunity anti-tumor immunotherapy. As the major infiltrating cells tumor microenvironment (TME), tumor-associated macrophages (TAMs) could be polarized into either M1 or pro-tumor M2 types based on various stimuli. Accordingly, targeted reprogramming TAMs to restore immune balance shows promise as an effective strategy. In this review, we aim target cGAS-STING for enhance We investigated double-edged sword effects of regulating TME. regulative roles its impact TME were further revealed. More importantly, several strategies targeting designed enhancing Taken together, might promising strategy
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Iron metabolism of neutrophils plays a vital role in neutrophil extracellular trap (NET) formation, which presents as one the major hurdles to immune response tumor microenvironment. Here, we developed peptide-drug conjugate (PDC)-based transformable iron nanochelator (TIN) equipped with ability regulate neutrophils, endowing inhibition NET formation and ensuing immunosuppression functions. The TIN could expose iron-binding motifs through elastase-mediated morphological transformation from nanoparticles β-sheet nanofibers, further evolve into stable α-helix nanofibers after chelation iron(II) ions. This process enables highly specific regulation ions turns an efficient way inhibiting improving response. Furthermore, showed improved therapeutic effect combination protein arginine deiminase 4 inhibitors synergistically boosted anti-PD-L1 treatment. study designates iron-regulation strategy inhibit provides alternative approach modulation perspective targeting cancer immunotherapy.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1298 - 1298
Published: April 11, 2025
As one of the leading components in immune system, neutrophils tumor microenvironment (TME) have received considerable attention recent years. The tumor-killing effects a variety tumors been reported. However, functions remain to be completely elucidated, and both anti-tumor tumor-promotion activities This review focuses on characteristics their mechanisms action TME, with an emphasis activity, including reactive oxygen species (ROS)-induced killing, cytotoxic T lymphocytes (CTLs)-induced trogocytosis, enzymes, trained immunity. Furthermore, possible targets methods treatment regimens for are explored, aim exploring use future as potential strategy.
Language: Английский
Citations
0
International Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 5(2), P. 16 - 16
Published: April 18, 2025
Background/Objectives: Tumor cell migration depends on the actin cytoskeleton modified by actin-binding proteins (ABPs). Overexpression of cofilin or thymosin beta4 (Tß4) has been correlated with an increase decrease in their migratory activity, respectively. Methods: Immunostaining tumor cells and transfection EGFP-tagged bicistronic vectors leading to independent expression EGFP Tß4. Determination transwell agarose drop assay. Results: We modulated intracellular concentrations Tß4 two colon (3LNLN EB3) one breast carcinoma (MDA-MB-231) line analyzed activity. Increasing wild-type did not alter whereas constitutively active S3A–cofilin mutant elevated migration. Transfection up- downregulation showed that MDA-MB-231 3LNLN responded a migration, Exposure increasing extracellular Tβ4 (or His-tagged Tß4) induced biphasic response being highest around 0.24 µM decreased at higher exposed anti-His antibody indicated its uptake co-localizing integrin-linked kinase attachment points. Furthermore, exposure led increased phosphorylation AKT1/2 secretion matrix metalloproteases. These effects were abrogated after 2.8 His-Tß4, also inducing apoptosis number cells. Conclusions: can be inhibited high
Language: Английский
Citations
0
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: May 20, 2025
Language: Английский
Citations
0
Translational Lung Cancer Research, Journal Year: 2024, Volume and Issue: 13(6), P. 1277 - 1295
Published: June 1, 2024
Immune therapy has become first-line treatment option for patients with lung cancer, but some respond poorly to immune therapy, especially among adenocarcinoma (LUAD). Novel tools are needed screen potential responders in LUAD patients, better predict the prognosis and guide clinical decision-making. Although many efforts have been made responsiveness of results were limited. During era immunotherapy, this study attempts construct a novel prognostic model by utilizing differentially expressed genes (DEGs) differential responses.
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 24, 2024
Background Neutrophil extracellular traps (NETs) have long been consistently considered an innate immune defense against foreign pathogens, but this oversimplified view has decelerated the progression of perceiving NET biology in chronic diseases. It is now increasingly accepted that NETs are not exclusive to anti-infection responses, also central players with a double-edged sword role cancer progression. gradually emerged as tumor diagnostic, predictive, and prognostic biomarkers, strenuous endeavors devoted tapping their potential new therapeutic targets. Correspondingly, boom studies on tumors recent years achieved series scientific outputs, which opens up perspective for sophisticated landscapes microenvironment. However, there still much room translate NET-targeted immunotherapies into clinical practice. Therefore, it necessary explore knowledge structure latent hotspots links between using bibliometric analysis. Methods publications from 2006 2024 were extracted Web Science Core Collection. Bibliometric analysis visualization conducted Microsoft Excel, VOSviewer, CiteSpace, R-bibliometrix. Results The included 1,339 authored by 7,747 scholars affiliated 1,926 institutions across 70 countries/regions relevant articles published 538 journals. Despite China’s maximum number publications, United States continued dominate field global cooperation center overwhelming citation counts. Frontiers Immunology most whereas Blood was cited journal. Wagner, Denisa D. Kaplan, Mariana J. concurrently both top 10 prolific authors author lists. Tumor microenvironment immunotherapy will likely be focus future research. Conclusions A comprehensive first map current landscape link hope providing guidance fresh perspectives further research field. promising antitumor targets, perhaps eventual destination realm
Language: Английский
Citations
1
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2125 - 2126
Published: July 11, 2024
Language: Английский
Citations
0