Effect of Mild Conditions on PVA-Based Theta Gel Preparation: Thermal and Rheological Characterization DOI Open Access

Simone Pepi,

L Talarico, Gemma Leone

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12039 - 12039

Published: Nov. 9, 2024

Polyvinyl alcohol (PVA), possessing a strong ability to form hydrogels, has been widely used for various pharmaceutical and biomedical applications. In particular, the use of PVA-PEG in theta gels altered cartilage treatment attracted an enormous amount attention last 20 years. this paper, we prepared 42 at room temperature aqueous environment, testing crystallization occurrence basic pH (10 or 12). Using statistical approach, effect PEG molecular weight, PVA weight alkaline values on water content mechanical performance was evaluated. The procedure permitted maintain swelling properties comparable those human cartilage, from 60% 85%, with both polymers having same influence. MW mainly affected hydrophilic properties, whereas thermal were mostly influenced by PVA. shear compression behavior produced materials polymers’ MWs. sample obtained using 125 kDa as porogen appeared be most suitable one disease treatment, it had equilibrium modulus range 50–250 kPa, close that native articular well optimal response under along entire analyzed frequency mean value 0.12 MPa coefficient friction (COF) which remained 0.10 all tested sliding speeds (mm/s).

Language: Английский

Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels DOI Open Access
Peyman Karami, Alexis Laurent, Virginie Philippe

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9984 - 9984

Published: Sept. 16, 2024

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage promotion tissue engineering, offering key advantages such enhanced integration therapeutic potential. This comprehensive review navigates landscape adhesive repair, discussing identified challenges, shortcomings current treatment options, unique hydrogel products scaffolds. While emphasizing critical need situ lateral with surrounding tissues, we dissect limitations outline future perspectives scaffolds repair. Moreover, examine translation pathway regulatory considerations specific hydrogels. Overall, this synthesizes insights knowledge gaps highlights directions research regarding hydrogel-based devices advancing engineering.

Language: Английский

Citations

4
Bio-inspired wet/lubricious/adhesive soft matter and performance control in-between DOI Creative Commons
Shuanhong Ma, Desheng Liu, Wenbo Sheng

et al.

Advanced bionics., Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

4
Continuous magnetic-gradient hydrogel with augmented mechanical span and reverse-directional polysaccharides distribution for integrated repair of osteochondral defects DOI
Junwei Xu, Yi Cui, Xuemei Sun

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112361 - 112361

Published: March 1, 2025

Language: Английский

Citations

0
3D‐Printed In Situ Growth of Bilayer MOF Hydrogels for Accelerated Osteochondral Defect Repair DOI

Kaiqi Qin,

Xinyue Huang, Shengfeng Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 17, 2024

Abstract Repairing osteochondral (OC) defect presents a significant challenge due to the intricate structural requirements and unpredictable differentiation pathways of bone marrow mesenchymal stem cells (BMSCs). To address this challenge, novel biomimetic OC hydrogel scaffold is developed that features structure soft hard components. This incorporates bilayer metal–organic frameworks (MOFs), specifically ZIF‐67 in upper layer ZIF‐8 lower layer, achieved through an situ printing process. configuration enables spatial temporal modulation BMSC by controlling release Co 2 ⁺ Zn ⁺. The results demonstrate MOF hydrogels significantly outperform either lack MOFs or contain single type enhancing repair outcomes rabbit models knee defects. improved regenerative efficacy attributed distinct chondrogenic osteogenic cues provided MOFs, effectively guiding BMSCs toward enhanced tissue regeneration. customizable not only opens new avenues for innovative therapeutic strategies but also holds great promise widespread clinical applications.

Language: Английский

Citations

2
Tannic Acid-Based Biomimetic Nanomedicine with Pathological Reactive Oxygen Species-Responsive Cargo Release for Relieving Inflammation in Rheumatoid Arthritis DOI
Xiong Zhao, Shuai Wu, Ni Sheng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 59789 - 59802

Published: Oct. 25, 2024

Rheumatoid arthritis (RA) is a chronic disease characterized by immune cell infiltration and cartilage damage. The local lesion of RA shows severe oxidative stress proinflammatory cytokine secretion. For drug therapy, the efficacy agents, such as methotrexate (MTX), may be greatly limited, resulting from low bioavailability, clearance, toxic side effects. A nanocarrier (TA-PBA NPs) was developed with anti-inflammatory antioxidant activities, combined MTX to prepare nanomedicine (MTX for synergistic treatment RA. Moreover, inspired biological functions homing inflammation macrophages, biomimetic camouflaged macrophage membrane (MM@MTX constructed. TA-PBA NPs could timely promote release in response overaccumulated ROS exhibit high activities alleviating progression. experimental results confirmed that MM@MTX significantly reduce secretion cytokines (TNF-α) while increasing typical (IL-10), phenotype transformation macrophages M1 M2, up-regulate Nrf2-keap1 pathway-related proteins (HO-1 NRF2) positively regulate effectively inhibiting development. Thus, represent possible candidate safe efficient nanotherapy platform management.

Language: Английский

Citations

1
Effect of Mild Conditions on PVA-Based Theta Gel Preparation: Thermal and Rheological Characterization DOI Open Access

Simone Pepi,

L Talarico, Gemma Leone

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12039 - 12039

Published: Nov. 9, 2024

Polyvinyl alcohol (PVA), possessing a strong ability to form hydrogels, has been widely used for various pharmaceutical and biomedical applications. In particular, the use of PVA-PEG in theta gels altered cartilage treatment attracted an enormous amount attention last 20 years. this paper, we prepared 42 at room temperature aqueous environment, testing crystallization occurrence basic pH (10 or 12). Using statistical approach, effect PEG molecular weight, PVA weight alkaline values on water content mechanical performance was evaluated. The procedure permitted maintain swelling properties comparable those human cartilage, from 60% 85%, with both polymers having same influence. MW mainly affected hydrophilic properties, whereas thermal were mostly influenced by PVA. shear compression behavior produced materials polymers’ MWs. sample obtained using 125 kDa as porogen appeared be most suitable one disease treatment, it had equilibrium modulus range 50–250 kPa, close that native articular well optimal response under along entire analyzed frequency mean value 0.12 MPa coefficient friction (COF) which remained 0.10 all tested sliding speeds (mm/s).

Language: Английский

Citations

0