The molecular mechanisms, roles, and potential applications of PANoptosis in cancer treatment DOI Creative Commons
Wenyuan Ma, Qiang Wang,

Lanfang Guo

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

PANoptosis, a newly identified form of programmed cell death regulated by the panoptosome complex, exhibits key characteristics apoptosis, pyroptosis and necroptosis. It exerts substantial influence on initiation progression spectrum diseases, particularly in cancer, where its impact is increasingly being recognized. PANoptosis closely related to tumorigenesis, carcinogenesis, metastasis, chemotherapy resistance, as well prediction therapeutic responses prognosis cancer patients. In this review, we first review discovery systematically analyze composition panoptosome. Subsequently, examine role various types encompassing function within tumor microenvironment, drug predictive prognosis. Ultimately, delve into strategies for targeting therapy, including molecules pathway, such ZBP1, RIPK1, RIPK3, Caspases other novel like nanoinducers viral vectors. This aims provide references assistance research application treatment.

Language: Английский

PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis DOI Creative Commons
Chunxia Shi, Pan Cao, Yukun Wang

et al.

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 1523 - 1532

Published: April 1, 2023

Abstract: PANoptosis is a new cell death proposed by Malireddi et al in 2019, which characterized pyroptosis, apoptosis and necroptosis, but cannot be explained any of them alone. The interaction between necroptosis involved PANoptosis. In this review, from the perspective PANoptosis, we focus on relationship key molecules process formation PANoptosome, as well role diseases. We aim to understand mechanism provide basis for targeted intervention PANoptosis-related treat human Keywords: apoptosis,

Language: Английский

Citations

75
PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment DOI Creative Commons
Jie Gao,

Anying Xiong,

Jiliu Liu

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(7), P. 970 - 983

Published: March 29, 2024

Abstract This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence apoptosis, pyroptosis, necroptosis, plays crucial role cell death immune response regulation. The study delves into molecular pathways each mechanism their crosstalk within emphasizing shared components like caspases PANoptosome complex. It highlights significant various cancers, including respiratory, digestive, genitourinary, gliomas, breast showing impact on tumorigenesis patient survival rates. We further discuss interwoven relationship between tumor microenvironment (TME), illustrating how influences behavior progression. underscores dynamic interplay tumors microenvironments, focusing roles different cells interactions with cancer cells. Moreover, presents new breakthroughs therapy, potential targeting to enhance anti-tumor immunity. outlines strategies manipulate for therapeutic purposes, such as key signaling molecules caspases, NLRP3, RIPK1, RIPK3. novel treatments immunogenic PANoptosis-initiated therapies nanoparticle-based is also explored.

Language: Английский

Citations

33
A surgical orthotopic xenograft approach with immune response for colorectal cancer research DOI Creative Commons
Xiaoying Hou, Xiaoxuan Li, Fang Qian

et al.

Animal Models and Experimental Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract The high morbidity and mortality of colorectal cancer (CRC) is a major challenge in clinical practice. Although series alternative research models CRC have been developed, appropriate orthotopic animal that reproduce the specific response as well pathophysiological immune features are still lacking. In current study, we constructed xenograft model by implanting tumor tubes at colorectum mice monitored development using bioluminescence imaging. This successfully recapitulates chemotherapy efficacy, including reduced total flux, weight, expression Ki67 after treatment first‐line regime (FOLFOX: oxaliplatin 5‐fluorouracil/calcium folinate). also reproduced immunosuppressive effect FOLFOX, indicated decreased infiltration macrophages increased Treg cells tumor. Additionally, approach may be applied immunodeficient NCG/NSG for constructing patient‐derived xenografts, being used precision medicine drug evaluation. We believe successful surgical deserves to popularized, which will provide convenient efficient platform in‐depth mechanism exploration preclinical

Language: Английский

Citations

2
Effect of the β-glucan from Lentinus edodes on colitis-associated colorectal cancer and gut microbiota DOI

Ningyue Liu,

Siwei Zou,

Conghua Xie

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 316, P. 121069 - 121069

Published: May 26, 2023

Language: Английский

Citations

33
PANoptosis: Emerging mechanisms and disease implications DOI

Zehong Qi,

Lili Zhu, Kangkai Wang

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 333, P. 122158 - 122158

Published: Oct. 6, 2023

Language: Английский

Citations

26
NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers DOI Open Access
Yujie Zhou,

Songyan Yu,

Wenyong Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14511 - 14511

Published: Sept. 25, 2023

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate adaptive immunity. As member of pattern recognition (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways lead to the secretion various cytokines. In recent years, cumulative studies have revealed significant impacts gastrointestinal (GI) inflammatory diseases cancers. Deciphering mechanism NLR may provide new opportunities for development therapeutic strategies related GI This review presents structures NLRs, summarizes advances regarding cancers describes comprehensive based on this pathway.

Language: Английский

Citations

23
Role of the gut microbiota in tumorigenesis and treatment DOI Creative Commons
Qingya Liu,

Yun Yang,

Meng Pan

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2304 - 2328

Published: Jan. 1, 2024

The gut microbiota is a crucial component of the intricate microecosystem within human body that engages in interactions with host and influences various physiological processes pathological conditions.In recent years, association between dysbiosis tumorigenesis has garnered increasing attention, as it recognized hallmark cancer scientific community.However, only few microorganisms have been identified potential drivers tumorigenesis, enhancing molecular understanding this process substantial importance clinical relevance for treatment.In review, we delineate impact on treatment multiple types while also analyzing associated mechanisms.Moreover, discuss utility data diagnosis patient stratification.We further outline current research harnessing prospects challenges approach.

Language: Английский

Citations

12
Mechanisms and effects of NLRP3 in digestive cancers DOI Creative Commons

Yuxin Si,

Lei Liu,

Zhe Fan

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 5, 2024

Abstract Inflammasomes are thought to be important mediators of host defense against microbial pathogens and maintenance gastrointestinal tract homeostasis. They can modulate caspase-1 promote IL-18 IL-1β secretion phagocytosis induced by bacterial pathogens. NLRP3 is an inflammasome comprising a multiprotein complex assembled pattern recognition receptors in the cell cytoplasm. It crucial component innate immune system. Dysregulation may contribute inflammatory diseases intestinal cancers. Recent research suggests that plays essential role tumor development; therefore, intensive study its mechanism warranted as it could play key treatment digestive system tumors. In this review, we discuss tumors response strategies for potential use treatment.

Language: Английский

Citations

10
Pyroptosis: a new insight into intestinal inflammation and cancer DOI Creative Commons

Limin Chao,

Wenjing Zhang,

Yuchao Feng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Pyroptosis is an innate immune response triggered by the activation of inflammasomes various influencing factors, characterized cell destruction. It impacts system and cancer immunotherapy. In recent years, roles pyroptosis in intestinal inflammation have been continuously confirmed. This article reviews latest progress mechanisms, new discoveries inflammasomes, mutual regulation between their applications diseases. Additionally, potential synergistic treatment mechanisms diseases with are summarized, challenges future directions discussed, providing ideas for therapy.

Language: Английский

Citations

10
Intestinal Dysbiosis: Microbial Imbalance Impacts on Colorectal Cancer Initiation, Progression and Disease Mitigation DOI Creative Commons
Mary Garvey

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 740 - 740

Published: March 26, 2024

The human gastrointestinal tract houses a diverse range of microbial species that play an integral part in many biological functions. Several preclinical studies using germ-free mice models have demonstrated the gut microbiome profoundly influences carcinogenesis and progression. Colorectal cancer appears to be associated with dysbiosis involving certain bacterial species, including F. nucleatum, pks+ E. coli, B. fragilis, virome commensals also disrupted patients. A toward these pro-carcinogenic increases significantly CRC patients, reduced numbers preventative Clostridium butyicum, Roseburia, Bifidobacterium evident. There is correlation between infection CRC. particular, strongly where it therapeutic resistance poor outcomes carcinogenic mode action pathogenic bacteria result genotoxicity, epigenetic alterations, ROS generation, pro-inflammatory activity. aim this review discuss their impact on colorectal terms disease initiation, progression, metastasis. potential anticancer peptides as agents or adjuvants discussed, novel treatment options are required combat high levels current pharmaceutical options.

Language: Английский

Citations

9