Journal of Ultrasound, Journal Year: 2022, Volume and Issue: 26(2), P. 401 - 408
Published: Nov. 4, 2022
Language: Английский
Medical Physics, Journal Year: 2023, Volume and Issue: 50(10), P. 5956 - 5968
Published: May 24, 2023
The persistent development of focused ultrasound (FUS) thermal therapy in the context oncology creates need for tissue-mimicking tumor phantom models early-stage experimentation and evaluation relevant systems protocols.This study presents a tumor-bearing tissue model testing magnetic resonance imaging (MRI)-guided FUS (MRgFUS) ablation protocols equipment based on MR thermometry.Normal was mimicked by pure agar gel, while simulator differentiated from surrounding material including silicon dioxide. characterized terms acoustic, thermal, MRI properties. US, MRI, computed tomography (CT) images were acquired to assess contrast between two compartments. phantom's response heating investigated performing high power sonications with 2.4 MHz single element spherically ultrasonic transducer 3T scanner.The estimated properties fall within range literature-reported values soft tissues. inclusion dioxide offered excellent visualization CT. thermometry revealed temperature elevations levels clear evidence larger heat accumulation owing dioxide.Overall, findings suggest that proposed constitutes simple inexpensive tool preclinical MRgFUS studies, potentially other image-guided applications upon minimal modifications.
Language: Английский
Citations
11
Physica Medica, Journal Year: 2025, Volume and Issue: 131, P. 104932 - 104932
Published: Feb. 11, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: March 18, 2023
Abstract High intensity focused ultrasound (HIFU) systems have been approved for therapeutic delivery to cause tissue ablation or induced hyperthermia. Microbubble agents also used in combination with sonication exposures. These require temperature feedback and monitoring prevent unstable cavitation excess heating. Previous work has utilized lower power pressure oscillate microbubbles transfer energy endothelial cells the absence of thermally damage that can radiosensitize tumors. This investigated whether reduced acoustic on a commercial available MR-integrated HIFU system could result enhanced radiation-induced tumor response after exposure ultrasound-stimulated (USMB) therapy. A commercially was hyperthermia calibration provided by manufacturer. The transducer calibrated reach peak negative − 750 kPa. Thirty male New Zealand white rabbits bearing human derived PC3 tumors were grouped receive no treatment, 14 min USMB, 8 Gy radiation separate irradiation cabinet, combined treatments. In vivo changes collected using MR thermometry at center far-field muscle region. Tissues specimens 24 h post Tumor cell death measured compared untreated controls through hematoxylin eosin staining immunohistochemical analysis. desired kPa previous USMB occurred approximately an input 5 W. Temperature limited under 4 °C ten twelve monitored. median region leg 2.50 groups receiving alone radiation. Finally, statistically significant demonstrated analysis therapy group controls. MR-guided able effectively treat rabbit model Future find use levels mechanically stimulate without requiring high thermal doses elicit antitumor response.
Language: Английский
Citations
7
IEEE Transactions on Mobile Computing, Journal Year: 2024, Volume and Issue: 23(12), P. 11670 - 11684
Published: May 8, 2024
We propose a novel approach to smart spot-beamforming (SBF) in the Fresnel zone leveraging extremely large-scale programmable metasurfaces (ELPMs). A SBF scheme aims adaptively concentrate aperture's radiating power exactly at desired focal point (DFP) 3D space utilizing some Machine Learning (ML) method. This offers numerous advantages for next-generation networks including ultra-high-speed wireless communication, location-based multiple access (LDMA), efficient transfer (WPT), interference mitigation, and improved information security. necessitates ELPMs with precise channel state (CSI) all ELPM elements. However, obtaining exact CSI is not feasible environments; we alleviate this by developing CSI-independent ML based on TD3 deep-reinforcement-learning (DRL) While proposed ML-based well-suited relatively small-size arrays, computational complexity unaffordable ELPMs. To overcome limitation, introduce modular highly scalable structure composed of sub-arrays, each equipped TD3-DRL optimizer. setup enables collaborative optimization radiated DFP, significantly reducing while enhancing learning speed. The structure's benefits terms spot-like distribution, convergence rate, scalability are validated through simulation results.
Language: Английский
Citations
2
Computer Methods and Programs in Biomedicine, Journal Year: 2023, Volume and Issue: 240, P. 107726 - 107726
Published: July 19, 2023
Language: Английский
Citations
4
Ultrasonics, Journal Year: 2024, Volume and Issue: 138, P. 107263 - 107263
Published: Feb. 10, 2024
Language: Английский
Citations
1
International Journal of Medical Robotics and Computer Assisted Surgery, Journal Year: 2022, Volume and Issue: 18(3)
Published: March 8, 2022
High-quality methods for Magnetic Resonance guided Focussed Ultrasound (MRgFUS) therapy planning are needed safe and efficient clinical practices. Herein, an algorithm full coverage path based on preoperative MR images is presented.The software functionalities of MRgFUS robotic system were enhanced by implementing the developed algorithm. The algorithm's performance in accurate following a Zig-Zag pathway was assessed images. planned sonication paths performed acrylic films using carrying 2.75 MHz single element transducer.Ablation patterns successfully produced overlapping lesions with excellent match between experimental lesion shapes.The advanced proven executing ablation any segmented target. reliability could be through development fully automated segmentation procedure.
Language: Английский
Citations
5
Ultrasonics, Journal Year: 2023, Volume and Issue: 132, P. 106974 - 106974
Published: March 9, 2023
Language: Английский
Citations
2
Journal of Medical Ultrasound, Journal Year: 2024, Volume and Issue: 32(4), P. 297 - 308
Published: Feb. 26, 2024
Background: The main goal of the study was to find magnetic resonance imaging (MRI) parameters that optimize contrast between tissue and thermal lesions produced by focused ultrasound (FUS) using T1-weighted (T1-W) T2-weighted (T2-W) fast spin echo (FSE) sequences. Methods: FUS sonications were performed in ex vivo porcine a single-element transducer 2.6 MHz 1.5 3 T MRI scanners. difference relaxation times as well impact critical on resultant contrast-to-noise ratio (CNR) coagulated normal tissues assessed. Discrete overlapping inflicted with simultaneous acquisition T2-W FSE images. Results: are characterized lower than intact tissue. CNR values above 80 sufficient for proper lesion visualization. For T1-W imaging, repetition time close 1500 ms considered optimum obtaining sufficiently high at minimum cost. Echo 50 offered maximum imaging. Monitoring acute during grid successfully. Lesions appeared hypointense spots excellent from surrounding Conclusion: monitoring signal intensity changes sonication patterns optimized sequence can provide useful information about progression success ablation. This preliminary demonstrated feasibility proposed method should be supported studies assess its clinical potential.
Language: Английский
Citations
0
Journal of Medical Ultrasound, Journal Year: 2024, Volume and Issue: 33(1), P. 1 - 14
Published: April 22, 2024
Abstract Background: Establishing an efficient workflow is crucial for the success of magnetic resonance-guided focused ultrasound (MRgFUS) procedures. The current study provides a comprehensive description customized MRgFUS robotic body device preclinical use and accompanied software through experiments in excised porcine tissue. Methods: employed system comprises single-element spherically transducer 2.6 MHz that can be moved along four PC-controlled axes. A detailed essential functionalities its integration with 3T Siemens resonance imaging (MRI) scanner Access-I interactive remote control real-time access to data provided. Following treatment planning on preoperative MR images, tissue samples were sonicated rectangular irregular grid patterns varying ultrasonic parameters spatial step under software-based monitoring. Results: ablations ex vivo successfully performed utilizing multimodal monitoring approach combining MRI-based temperature, thermal dose, necrotic area mapping, thus demonstrating procedural workflow. simulated regions excellent agreement actual lesions revealed upon dissection highly consistent planned sonication patterns. software’s ability accurately identify where necrosis did not occur indicate user specific points re-sonicated was demonstrated. Conclusion: Overall, highlights critical aspects executing protocols within provided could serve as basis other researchers field.
Language: Английский
Citations
0