Development of a 3-D-printed mouse phantom to replace current mouse animal model DOI Creative Commons
Yong Uk Kye, Hyo Jin Kim, Chang Geun Lee

et al.

Nuclear Technology and Radiation Protection, Journal Year: 2024, Volume and Issue: 39(2), P. 121 - 126

Published: Jan. 1, 2024

Evaluating the radiation dose of target organs a laboratory mouse requires glass dosimeter to be surgically inserted at irradiated location. However, precisely inserting same location in different mice is rarely achieved, reducing reliability measured dose. To address this limitation, 3-D phantom was developed using computed tomography scanning and printing technology. The assessed four models: mouse, phantom, Monte Carlo N-Particle (MCNP) MCNP simulation. In all experiments, brain, heart, lungs, abdomen were with 100 mGy air kerma 6 mGyh?1 rate. A small volume into models assess dose, reading system evaluated dose-response curves. values 3-D-printed found differ by up 3.3 %. This study provides method accurately measure organs, enhancing pre-experiments.

Language: Английский

Tumor phantom model for MRI‐guided focused ultrasound ablation studies DOI Creative Commons
Anastasia Antoniou, Nikolas Evripidou, Leonidas Georgiou

et al.

Medical Physics, Journal Year: 2023, Volume and Issue: 50(10), P. 5956 - 5968

Published: May 24, 2023

The persistent development of focused ultrasound (FUS) thermal therapy in the context oncology creates need for tissue-mimicking tumor phantom models early-stage experimentation and evaluation relevant systems protocols.This study presents a tumor-bearing tissue model testing magnetic resonance imaging (MRI)-guided FUS (MRgFUS) ablation protocols equipment based on MR thermometry.Normal was mimicked by pure agar gel, while simulator differentiated from surrounding material including silicon dioxide. characterized terms acoustic, thermal, MRI properties. US, MRI, computed tomography (CT) images were acquired to assess contrast between two compartments. phantom's response heating investigated performing high power sonications with 2.4 MHz single element spherically ultrasonic transducer 3T scanner.The estimated properties fall within range literature-reported values soft tissues. inclusion dioxide offered excellent visualization CT. thermometry revealed temperature elevations levels clear evidence larger heat accumulation owing dioxide.Overall, findings suggest that proposed constitutes simple inexpensive tool preclinical MRgFUS studies, potentially other image-guided applications upon minimal modifications.

Language: Английский

Citations

11
Focused Ultrasound Sonications of Tumor Model in Head Phantom under MRI Monitoring: Effect of Skull Obstruction on Focal Heating DOI Creative Commons
Anastasia Antoniou,

Antreas Chrysanthou,

Leonidas Georgiou

et al.

Journal of Medical Physics, Journal Year: 2025, Volume and Issue: 50(1), P. 38 - 45

Published: Jan. 1, 2025

This study presents the outcomes of a series magnetic resonance imaging (MRI)-guided focused ultrasound (MRgFUS) sonications performed on an anatomically accurate head phantom with embedded tumor simulator to evaluate effectiveness partial and complete ablation obstruction from thin polymer skull mimics. The was subjected single grid using single-element concave transducer integrated MRI-compatible (FUS) robotic system. All experiments were carried out in high-field MRI scanner utilizing proton frequency thermometry T2-weighted (T2-W) turbo spin echo (TSE) induced thermal effects. FUS transmission through 1-mm thick three-dimensional-printed mimics compared unobstructed sonication circular aperture model. T2-W TSE demonstrated sharp contrast between hyperintense lesions. Complete coverage achieved robotic-assisted without mimic, as well resin mimic intervening beam. With lowest attenuation among tested polymers, resulted approximately 20% reduction focal temperature change sonication, yet still facilitated beam focusing, raising ablative levels. provides preliminary evidence for potential application biocompatible implant temporarily replace portion facilitating MRgFUS inoperable tumors transducer. tumor-embedded proven effective testing oncological protocols equipment.

Language: Английский

Citations

0
3-Dimensional printing and bioprinting in neurological sciences: applications in surgery, imaging, tissue engineering, and pharmacology and therapeutics DOI Creative Commons

S K Dhar,

Faraz Ahmad, Aditi Deshpande

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 9, 2025

Abstract The rapid evolution of three-dimensional printing (3DP) has significantly impacted the medical field. In neurology for instance, 3DP been pivotal in personalized surgical planning and education. Additionally, it facilitated creation implants, microfluidic devices, optogenetic probes, offering substantial implications research applications. 3D printed nasal casts are showing great promise targeted brain drug delivery. also aided creating “phantoms” aligning with advancements neuroimaging, design intricate objects investigating neurobiology sensory perception. Furthermore, emergence bioprinting (3DBP), a fusion cell biology, created new avenues neural tissue engineering. Effective ethical tissue-like biomimetic constructs enabled mechanistic, regenerative, therapeutic evaluations. While individual reviews have explored applications or 3DBP, comprehensive review encompassing success stories across multiple facets both technologies neurosurgery, neuro-regeneration lacking. This aims to consolidate recent achievements 3DBP various neurological science domains encourage interdisciplinary among neurologists, neurobiologists, engineers, order promote further exploration methodologies novel areas practice. Graphical abstract

Language: Английский

Citations

0
Development of a 3-D-printed mouse phantom to replace current mouse animal model DOI Creative Commons
Yong Uk Kye, Hyo Jin Kim, Chang Geun Lee

et al.

Nuclear Technology and Radiation Protection, Journal Year: 2024, Volume and Issue: 39(2), P. 121 - 126

Published: Jan. 1, 2024

Evaluating the radiation dose of target organs a laboratory mouse requires glass dosimeter to be surgically inserted at irradiated location. However, precisely inserting same location in different mice is rarely achieved, reducing reliability measured dose. To address this limitation, 3-D phantom was developed using computed tomography scanning and printing technology. The assessed four models: mouse, phantom, Monte Carlo N-Particle (MCNP) MCNP simulation. In all experiments, brain, heart, lungs, abdomen were with 100 mGy air kerma 6 mGyh?1 rate. A small volume into models assess dose, reading system evaluated dose-response curves. values 3-D-printed found differ by up 3.3 %. This study provides method accurately measure organs, enhancing pre-experiments.

Language: Английский

Citations

0