Metabolic dysfunction-associated steatotic liver disease in adults

Nature Reviews Disease Primers, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 6, 2025

Language: Английский

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The Effect of Backscatter Anisotropy in Assessing Hepatic Steatosis Using Ultrasound Hepatorenal Index

Journal of Ultrasound in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Objectives To discuss challenges in assessing hepatic steatosis using ultrasound hepatorenal index (HRI). Methods We retrospectively analyzed HRI and liver magnetic resonance imaging‐based proton density fat fraction (MRI‐PDFF) 134 adult participants (53 men 81 women, mean age 55 years). The diagnostic performance of for determining was tested by the area under receiver operating characteristic curve (AUROC) MRI‐PDFF as reference. Regression plots were employed to compare sampling sites kidney that used calculate HRIs. Results In 11 cases (8.2%), we failed acquire measurements. remaining 123 cases, AUROC (cutoff: 1.69 ± 0.13 [mean standard deviation]) defining threshold diagnosing 0.83. 60 (49%) with measurement IQR/median >0.3, slopes regression lines showed backscatter intensity changes consistent signal attenuation. However, kidney, inverted yielding position‐dependent cutoff values, mid‐pole = 2.24 0.20 upper pole 1.08 0.16. Conclusions is estimate based on backscattered ultrasound. order compensate effects such body habitus transducer frequency, divided from a corresponding region at same depth right renal cortex. Theoretically, this compensation should make position independent. Yet, due cortical anisotropy, method does not work general, potentially producing inaccurate estimates.

Language: Английский

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Intersystem and Interoperator Agreement of US Attenuation Coefficient for Quantifying Liver Steatosis

Radiology, Journal Year: 2024, Volume and Issue: 313(1)

Published: Oct. 1, 2024

Substantial variability in US attenuation coefficient values across systems precludes their interchangeability for diagnosing and monitoring liver steatosis.

Language: Английский

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Ultrasound backscatter coefficient for fat quantification is affected by the measurement depth

Abdominal Radiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Language: Английский

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Construction of a Compound Model to Enhance the Accuracy of Hepatic Fat Fraction Estimation with Quantitative Ultrasound

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 203 - 203

Published: Jan. 17, 2025

Background: we evaluated regression models based on quantitative ultrasound (QUS) parameters and compared them with a vendor-provided method for calculating the fat fraction (USFF) in metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: We measured attenuation coefficient (AC) backscatter-distribution (BSC-D) determined USFF during calculated magnetic resonance imaging proton-density (MRI-PDFF) steatosis grade (S0-S4) combined retrospective-prospective cohort. trained multiple using single or various QUS as independent variables to forecast MRI-PDFF. Linear nonlinear were five-time repeated three-fold cross-validation retrospectively collected dataset of 60 MASLD cases. models' Pearson correlation (r) intraclass (ICC) prospectively test set 57 Results: The linear multivariable model (r = 0.602, ICC 0.529) 0.576, 0.54) more reliable S0- S1-grade than 0.492, 0.461). In S2 S3 grades, 0.377, 0.32) AC-only 0.375, 0.313) approximated agreement surpassed that 0.394, 0.265). searched parameter grid find optimal thresholds (AC ≥ 0.84 dB/cm/MHz, BSC-D 105), above which switching from 0.752, 0.715) 0.719, 0.641) could improve overall fit 0.775, 0.718). Conclusions: are robust diagnosing low-grade steatosis. Switching enhance MRI-PDFF advanced

Language: Английский

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MPUS is a big step forward for small organs

Ultraschall in der Medizin - European Journal of Ultrasound, Journal Year: 2025, Volume and Issue: 46(01), P. 8 - 13

Published: Feb. 1, 2025

Multiparametric imaging combines the information from different functional sequences or techniques and is best known multiparametric MRI in which of a number used to investigate lesions. By combining analysis several structural tissue properties, characterization lesions much more precise than by just relying on one sequence technique only. In fact, combination variety procedures as "one-shop" procedure resulted term "multiparametric". daily clinical practice neuroimaging, liver imaging, musculoskeletal breast prostate etc. The 'multiparametric' can also be applied computed tomography (CT) it allows 3D-reconstruction at phases after contrast administration. CT has improved visualization chest, pleural abdominal cavity revolutionized trauma management plays fundamental role diagnosis acute abdomen. Despite undisputed strengths CT, limitations are obvious: radiation exposure, foreign bodies with contraindication for MRI, patient movement without injection media, high cost availability and, above all, impossibity us bedside directly "at point need", claustrophobia significant proportion patients, sedation pediatric use others [1] [2]. recent decades, ultrasound outgrown one-dimensionality A-Mode frequency-dependent high-resolution morphological details B-Mode ways: processes mapped real time, displayed 4 D, interaction structures propagation characteristics sound waves qualitative quantitative elasticity strain shear wave elastography, fat infiltration attenuation potentially necro-inflammation using dispersion. Doppler contrast-enhanced quantitatively capture blood flow, vascular density vascularization patterns their surroundings real-time – highest temporal spatial resolution [3] [4] [5] [6]. This multitude properties achieved lower costs morbidity any other modality. since first 'multiparametric ultrasound' (MPUS) [7], years popularity was gained literature among scientific societies active field medical its describe modern various technologies precisely characterize focal surrounding parenchyma features, perhaps similar terminology [8]. Since foundation, European Federation Societies Ultrasound Medicine Biology (EFSUMB) established strong tradition supporting good promoting evidence-based medicine [9] [10]. Considering utility those newer techniques, EFSUMB published guidelines, technical reviews, position papers many areas including CEUS [11] [12] [13] [14], time intensity curves [15], elastographic [6], but interventional [16] [17] [18] [19] [20] [21] [22] [23] [24] gastrointestinal [25] [26] [27] [28] [29] [30]. light increasing publications need analyse benefits limitations, well standardize (MPUS), decided launch MPUS guidelines "small parts" (thyroid, testis, breast) proceed pancreatic application MPUS. Guidelines have already been World (WFUMB) close cooperation [31] [32].

Language: Английский

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Noninvasive Quantification of Hepatic Steatosis Using Ultrasound‐Derived Fat Fraction (CHESS2303): A Prospective Multicenter Study

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: Feb. 27, 2025

ABSTRACT Ultrasound‐derived fat fraction (UDFF) is designed to assess the hepatic content quantitatively. A multicenter study that verifies diagnostic performance of UDFF for detecting steatosis has not yet been reported. This aimed evaluate diagnosing and grading steatosis. Participants referred assessment were prospectively recruited from eight hospitals. All participants underwent magnetic resonance imaging proton density (MRI‐PDFF) examinations. MRI‐PDFF was used as reference From January 2023 July 2023, a total 300 included. The median body mass index 25.4 kg/m 2 (interquartile range: 22.7–28.1). values positively correlated with ( R = 0.80, p < 0.001). Using ≥ 5%, 15%, 25% standard mild, moderate, severe steatosis, best cutoff 7.6% (area under receiver operating characteristic curves [AUC] 0.90), 15.9% (AUC 22.3% 0.91), respectively. Thus, excellent in

Language: Английский

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A New Classification System for Fatty Liver—What Sonographers Should Know

Sonography, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

ABSTRACT Hepatic steatosis or fatty liver disease is a rapidly emerging health issue and closely linked to an increase in cardiometabolic conditions such as obesity type 2 diabetes. The nomenclature surrounding has recently undergone multiple reviews better reflect its underlying causes. This article recent guidelines changes will explore the various ultrasound technologies that are available for fat quantification, emphasising ultrasound's importance diagnosing monitoring steatosis. Sonographers must remain informed of classification criteria they directly impact their role detecting assessing

Language: Английский

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MR and Ultrasound for Liver Fat Assessment in Children: Techniques and Supporting Evidence

Journal of Magnetic Resonance Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Hepatic steatosis is a common imaging finding that can be sign of chronic liver disease, most often associated with metabolic dysfunction-associated steatotic disease (MASLD). Imaging techniques for evaluating range from basic qualitative assessments to advanced and highly accurate quantitative metrics. Among these, MRI-based proton density fat fraction (PDFF) widely regarded as reliable precise biomarker quantifying steatosis. Additionally, multiple ultrasound platforms now offer hepatic These methods include attenuation coefficient, speed sound, backscatter, or other multiparametric approaches such ultrasound-derived (UDFF) which combines backscatter quantification. Newer upcoming acoustic structure quantification (ASQ) tissue scatter distribution (TSI). Therefore, ultrasound-based measurements could potentially serve an effective screening tool in certain clinical settings, suspected MASLD. In this review, we describe how, why, when use MRI- assessing children. We discuss practical strategies adapting optimizing these pediatric considering indications, patient preparation, equipment needs, acquisition techniques, potential pitfalls, confounding factors. guidance provided interpretation reporting, along illustrative case examples. Evidence Level: N/A Technical Efficacy: Stage 5.

Language: Английский

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Challenges in the management of MetALD after liver transplantation

Metabolism and Target Organ Damage, Journal Year: 2025, Volume and Issue: 5(1)

Published: March 27, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated (ALD) are among the leading indications for transplantation (LT). The definition of metabolic dysfunction- (MetALD) identifies individuals with MASLD who consume moderate levels alcohol, representing a severe phenotype within (SLD) spectrum. Patients MetALD face higher risks post-LT complications, including syndrome, graft steatosis, fibrosis. Despite rising prevalence due to increasing obesity alcohol consumption, data on its recurrence or de novo development remain limited. management is particularly challenging interplay factors potential relapse. Current evidence suggests that recurrent often progresses more rapidly advanced fibrosis than in native livers, underscoring importance early detection management. Integrated approaches addressing both syndrome alcohol-related essential optimal Non-invasive diagnostic modalities, such as transient elastography specific biomarkers like phosphatidylethanol (Peth), promising assessing health relapse, respectively. Emerging therapies, glucagon-like peptide-1 receptor agonists (GLP1-RAs) fibroblast growth factor-21 (FGF21) analogs, offer dual-action benefits targeting dysfunction consumption. These innovations, coupled lifestyle interventions tailored immunosuppressive regimens, may improve patient outcomes reduce failure. This review highlights need multidisciplinary strategies further research optimize post-LT, aiming survival quality life this high-risk population.

Language: Английский

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