The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction DOI Creative Commons
Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk

et al.

Viruses, Journal Year: 2024, Volume and Issue: 17(1), P. 37 - 37

Published: Dec. 30, 2024

The global burden of COVID-19 continues to rise, and despite significant progress in vaccine development, there remains a critical need for effective treatments the severe inflammation acute lung injury associated with SARS-CoV-2 infection. In this study, we explored antiviral properties plant-derived complex consisting flavonol hydroxyorganic acid compounds. Our research focused on ability suppress activity several key proteins involved replication maturation SARS-CoV-2. These include ACE2 protein, HRV 3C Protease, Mpro (Main Protease). It was shown that plant-based effectively inhibited these viral proteins. addition its effects proteins, were Vero E6 cells. At dose 22 μg/mL, drug demonstrated maximum activity, significantly reducing vitro. preliminary studies, showed both prophylactic therapeutic potential, suggesting it may be useful preventing infection, as well severity disease once an individual has been infected Based compelling results propose potential compound Its inhibit exhibit protective positions valuable candidate further clinical evaluation. As fight against continues, therapies like could complement existing provide new options managing treating disease.

Language: Английский

Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of Peltophorum africanum Sond (Fabaceae): Systematic Review DOI Creative Commons
N.I. Mongalo, Maropeng Vellry Raletsena

Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 239 - 239

Published: Jan. 16, 2025

Plants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, Peltophorum africanum Sond is utilized by many different ethnic groups cure a wide range of illnesses. variety electronic databases, including ScienceDirect, Scopus, Scielo, Scifinder, PubMed, Web Science, Medline, Google Scholar, were search the literature on P. africanum, using key words such as uses, survey, pharmacology, antigonococcal, toxicity, phytochemistry others. Further data was obtained from several scholarly theses, dissertations, books general plant sciences, ethnomedicine, other pertinent ethnobotanical topics. The species possess very important pharmacological activities vitro, which includes antimicrobial, anti-HIV, antioxidant, anticancer, antidiabetic, activities. Phytochemically, possesses various classes compounds, dominated flavonols, may well explain its wider Although promising anti-HIV activity, mode action safety profiles also need be explored extracts exerted some degree mutagenicity. It further explore ethnoveterinary use against plethora nematodes that infects wild domestic Given potent vivo studies ascertain comprehensive toxicology species, thereby developing possible medications. elevated pharmaceutical product infections.

Language: Английский

Citations

1
Discovery and Rational Optimization of 2, 2'-((1h-Indole-2,3-Diyl) Bis (Thio))Diacetamide as Novel Sars-Cov-2 Rdrp Inhibitors DOI
Yu-Cheng Wang, Yu Shi, Jian‐Yuan Zhao

et al.

Published: Jan. 1, 2025

The COVID-19 pandemic has significantly strained global health infrastructures while profoundly affecting the socio-economic realm. RNA-dependent RNA polymerase (RdRp) plays a pivotal role in replication and transcription of viruses, making it critical target for antiviral drug development. In this work, we describe discovery, rational optimization, synthesis novel series non-nucleoside SARS-CoV-2 RdRp inhibitors featuring 2,2'-((1H-indole-2,3-diyl) bis (thio)) diacetamide core. inhibitory activity these compounds was evaluated, with most demonstrating higher effect than Remdesivir. Notably, potent candidates suppressed dose-dependently showed greater resistance to nsp14/nsp10 exonuclease-mediated proofreading Furthermore, 10b6 10b12 exhibited 1.6-2 times more effective EC50 values coronavirus HCoV-OC43 Remdesivir, highlighting their potential further development as broad-spectrum agents.

Language: Английский

Citations

0
Discovery and rational optimization of 2, 2′-((1H-indole-2,3-diyl) bis (thio))diacetamide as novel SARS-CoV-2 RdRp inhibitors DOI
Yu Shi, Jian‐Yuan Zhao, Min Li

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 123, P. 118153 - 118153

Published: March 7, 2025

Language: Английский

Citations

0
Promising Strategies for Accelerating the Eradication of Avian Leukosis in China DOI Creative Commons
Tuofan Li, Jingwen Li, Zeming Wang

et al.

Animals and zoonoses., Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Development of an Hepatitis B Pseudovirus System for Safe and Effective Antiviral Drug Screening DOI Creative Commons

Manasi Haval,

Su Li, Guofang Zhang

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100339 - 100339

Published: April 1, 2025

Language: Английский

Citations

0
Potential Benefits of In Silico Methods: A Promising Alternative in Natural Compound’s Drug Discovery and Repurposing for HBV Therapy DOI Creative Commons
Samuel Chima Ugbaja, Aganze Gloire-Aimé Mushebenge, Hezekiel M. Kumalo

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 419 - 419

Published: March 16, 2025

Hepatitis B virus (HBV) is an important global public health issue. The World Health Organization (WHO) 2024 Global Report estimated that the prevalence of people living with HBV infection 254 million, incidence 1.2 million new infections yearly. Previous studies have shown natural compounds antiviral inhibition potentials. In silico methods such as molecular docking, virtual screening, pharmacophore modeling, quantitative structure–activity relationship (QSAR), and dynamic simulations been successfully applied in identifying bioactive strong binding energies treatment targets. COVID-19 pandemic necessitated importance repurposing already approved drugs using methods. This study aimed at unveiling benefits techniques a potential alternative compounds’ drug discovery for therapy. Relevant articles from PubMed, Google Scholar, Web Science were retrieved analyzed. Furthermore, this comprehensively reviewed literature containing identified essential proteins. Notably, hesperidin, quercetin, kaempferol, myricetin, flavonoids hepatitis surface antigen (HBsAg). investigation reveals offer understanding mechanisms action, reveal previously overlooked viral targets (including PreS1 Domain HBsAg cccDNA (Covalently Closed Circular DNA) regulators, facilitate creation specific inhibitors. integration silico, vitro, vivo insights further highlight Moreover, combination compounds, approach, improves chances personalized precision medicine treatment. Therefore, we recommend strategies combine vivo, approaches to effective drugs.

Language: Английский

Citations

0
Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023) DOI Creative Commons
Yumeng Liu, Mengmeng Wang, Ning Yu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 3, 2024

Dengue virus (DENV) is the most widespread arbovirus. The World Health Organization (WHO) declared dengue one of top 10 global health threats in 2019. However, it has been underrepresented bibliometric analyses. This study employs analysis to identify research hotspots and trends, offering a comprehensive overview current dynamics this field. We present report spanning from 1995 2023 that provides unique longitudinal research, revealing significant trends shifts not extensively covered previous literature. A total 10,767 DENV-related documents were considered, with notable increase publications, peaking at 747 articles 2021. Plos Neglected Tropical Diseases become leading journal publishing 791 field—the highest number recorded. Our mapping DENV across multiple dimensions, including vector ecology, virology, emerging therapies. delineates complex network immune response genes, IFNA1, DDX58, IFNB1, STAT1, IRF3, NFKB1, highlighting themes, particularly impacts climate change new outbreaks on disease transmission. findings detail progress status key vaccine candidates, licensed Dengvaxia, newer vaccines such as Qdenga TV003, updated clinical trials. underscores advancements antiviral therapies control strategies for dengue, innovative drug candidates AT-752 JNJ-1802, potential repurposing agents like Ribavirin, Remdesivir, Lopinavir. Additionally, discusses biological methods, introduction Wolbachia-infected mosquitoes gene-editing technologies. critical role interdisciplinary collaboration advancing identifying areas needing further exploration, host-virus dynamics, development application drugs vaccines, use artificial intelligence. It advocates strengthened partnerships various disciplines effectively tackle challenges posed by DENV.

Language: Английский

Citations

2
The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction DOI Creative Commons
Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk

et al.

Viruses, Journal Year: 2024, Volume and Issue: 17(1), P. 37 - 37

Published: Dec. 30, 2024

The global burden of COVID-19 continues to rise, and despite significant progress in vaccine development, there remains a critical need for effective treatments the severe inflammation acute lung injury associated with SARS-CoV-2 infection. In this study, we explored antiviral properties plant-derived complex consisting flavonol hydroxyorganic acid compounds. Our research focused on ability suppress activity several key proteins involved replication maturation SARS-CoV-2. These include ACE2 protein, HRV 3C Protease, Mpro (Main Protease). It was shown that plant-based effectively inhibited these viral proteins. addition its effects proteins, were Vero E6 cells. At dose 22 μg/mL, drug demonstrated maximum activity, significantly reducing vitro. preliminary studies, showed both prophylactic therapeutic potential, suggesting it may be useful preventing infection, as well severity disease once an individual has been infected Based compelling results propose potential compound Its inhibit exhibit protective positions valuable candidate further clinical evaluation. As fight against continues, therapies like could complement existing provide new options managing treating disease.

Language: Английский

Citations

0