
Animals and zoonoses., Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Animals and zoonoses., Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Nature, Journal Year: 2024, Volume and Issue: 634(8034), P. 669 - 676
Published: July 25, 2024
The highly pathogenic avian influenza (HPAI) H5N1 virus clade 2.3.4.4b has caused the death of millions domestic birds and thousands wild in USA since January 2022 (refs.
Language: Английский
Citations
161Emerging infectious diseases, Journal Year: 2024, Volume and Issue: 30(9)
Published: Aug. 23, 2024
An outbreak of influenza A (H5N1) virus was detected in dairy cows the United States. We sialic acid -α2,3/α2,6-galactose host receptors bovine mammary glands by lectin histochemistry. Our results provide a rationale for high levels H5N1 milk from infected cows.
Language: Английский
Citations
21bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 3, 2024
Abstract An outbreak of H5N1 highly pathogenic influenza A virus (HPIAV) has been detected in dairy cows the United States. Influenza (IAV) is a negative-sense, single-stranded, RNA that not previously associated with widespread infection cattle. As such, cattle are an extremely under-studied domestic IAV host species. receptors on cells sialic acids (SAs) bound to galactose either α2,3 or α2,6 linkage. Human IAVs preferentially bind SA-α2,6 (human receptor), whereas avian have preference for (avian receptor). The receptor can further be divided into two receptors: isolated from chickens generally more tightly SA-α2,3-Gal-β1,4 (chicken duck SA-α2,3-Gal-β1,3 (duck We found all were expressed, different degree, mammary gland, respiratory tract, and cerebrum beef and/or human widely expressed bovine chicken dominated tract. In general, only low expression was observed neurons cerebrum. These results provide mechanistic rationale high levels reported infected milk show potential act as mixing vessel novel generation. Graphical abstract Created Biorender.com
Language: Английский
Citations
20Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1703 - 1703
Published: Oct. 30, 2024
The rapid geographic spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus in poultry, wild birds, and other mammalian hosts, including humans, raises significant health concerns globally. recent emergence HPAI agricultural animals such as cattle goats indicates ability to breach unconventional host interfaces, further expanding range. Among four types-A, B, C, D, are most susceptible D infection serve a reservoir for this seven-segmented virus. It is generally thought that bovines not hosts types viruses, type A. However, long-standing viewpoint has been challenged by outbreaks dairy cows United States. To date, into fourteen states, affecting 299 herds causing clinical symptoms reduced appetite, fever, sudden drop milk production. Infected can also transmit disease through raw milk. This review article describes current epidemiological landscape US its interspecies transmission events reported across globe. discusses viral determinants tropism, range, adaptative mutations various with natural experimental infections, vaccination strategies. Finally, it summarizes some immediate questions need be addressed better understanding biology, transmission, immune response bovines.
Language: Английский
Citations
7npj Vaccines, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 14, 2025
Abstract Influenza, a major “One Health” threat, has gained heightened attention following recent reports of highly pathogenic avian influenza in dairy cattle and cow-to-human transmission the USA. This review explores general aspects A virus (IAV) biology, its interactions with mammalian hosts, discusses key considerations for developing vaccines to prevent or curtail IAV infection bovine mammary gland spread through milk.
Language: Английский
Citations
1Food Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 104782 - 104782
Published: March 1, 2025
Language: Английский
Citations
0New Zealand Veterinary Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5
Published: April 22, 2025
Language: Английский
Citations
0Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12
Published: April 22, 2025
The widespread H5 clade 2.3.4.4b highly pathogenic avian influenza virus (HPAI) poses a significant threat to both domestic and wild mammals because of its rapid genetic evolution, cross-species transmissibility, host-range expansion. increasing number cases in mammalian species highlights the need for proactive measures driven by One Health approach. In this study, we explored potential use previously developed Newcastle disease (NDV)-vectored vaccine expressing hemagglutinin (rK148/22-H5) preclinical BALB/c mouse model. Two doses intramuscular vaccination with viable (107 EID50/0.1 mL) or inactivated rK148/22-H5 provided protection against lethal H5N1 HPAI. A greater than 100-fold reduction lung viral load was observed vaccinated group compared control group. Consistently, co-housed contact mice survived without evidence infection, whereas those became infected succumbed disease. demonstrated as HPAI candidate mammals, warranting further steps advance into clinical trials captive species.
Language: Английский
Citations
0Published: May 31, 2024
There are four types of influenza viruses: A, B, C, and D. Cattle susceptible to D infection serve as a reservoir for this seven-segmented virus. It is generally thought that bovines not host other viruses including type A. This long-standing viewpoint has been challenged by the recent highly pathogenic avian (HPAI) H5N1 outbreaks in dairy cows United States. To date, HPAI spread into nine states affecting 49 herds causing clinical symptoms reduced appetite, fever, sudden drop milk production. review article describes current epidemiological landscape U.S. interspecies transmission events mammals reported countries. The also discusses adaptation mutations mammalian hosts vaccination strategies. Finally, it summarizes some immediate questions need be addressed towards better understanding biology, transmission, immune response bovines.
Language: Английский
Citations
3Veterinary Research, Journal Year: 2024, Volume and Issue: 55(1)
Published: Nov. 9, 2024
The present study aimed to determine the dynamics of influenza A virus (IAV) infection in two endemically infected farms (F1 and F2), where a longitudinal follow-up piglets was performed from birth 8-12 weeks age. During study, highly virulent isolate porcine reproductive respiratory syndrome (PRRSV) introduced on both farms. This allowed us examine impact such introduction patterns infection, disease, antibody response pigs IAV infection. new PRRSV strain coincided with change In F1, cumulative incidence increased 20% before outbreak 67.5%, together existence animals that tested positive for (RT‒qPCR) nasal swabs or more consecutive samples. F2, 50% 70%, proportion prolonged shedders sharply. Additionally, some were same twice during observation period. contrast previous reports, our revealed shedding not related titres maternally derived antibodies at time but significantly (p < 0.05) status. Notably, after outbreak, high IAV-infected did seroconvert, which hemagglutination inhibition against when infected.
Language: Английский
Citations
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