Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Hydrothermally prepared grain-like CeO 2 nanostructures were useful for creating a high-performance and non-enzymatic sensor uric acid detection.
Language: Английский
ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(3), P. 3576 - 3590
Published: Jan. 15, 2021
The plasmonic properties of gold nanoparticles (AuNPs) are a promising tool to develop sensing alternatives traditional, enzyme-catalyzed reactions. need for alternatives, especially in underdeveloped areas the world, has given rise application nonenzymatic approaches paired with cellulosic substrates biochemical analysis. Herein, we present three individual, low-step, wet-chemistry, colorimetric assays target biomarkers, namely, glucose, uric acid, and free cholesterol, relevant diabetes control their translation into paper-based microfluidic platforms multiplexed For glucose determination, an situ AuNPs synthesis approach was applied developed μPAD, giving semiquantitative measures physiologically range. acid cholesterol modified were used functionalize paper gold-on-paper optical changing based on different aggregation degrees hydrophobic particles dependent analyte concentration. These show sensitivity ranges limits detection compatible level determination comparable those similar enzymatic, systems, relying only transduction without enzymatic activity or other chromogenic substrates. resulting integrated single 3D, multiplex device using microfluidics, showing capability performing distinct requirements terms sample flow uptake test zones combination both horizontal vertical flows inside same device. presented allows multiparametric, metabolite levels from complex matrix drop digital color analysis, potential development low-cost, low-complexity tools diagnostics toward point-of-care.
Language: Английский
Citations
80
Hypertension, Journal Year: 2022, Volume and Issue: 79(8), P. 1814 - 1823
Published: July 13, 2022
Uric acid (UA) concentration within carotid plaque and its association with cerebrovascular events have not been detected or quantified. Systemically, serum UA is a marker of inflammation risk factor for atherosclerosis. However, instability stroke pathogenesis remains unclear. In patients undergoing endarterectomy, we aimed to determine whether present differentially in symptomatic versus asymptomatic plaques associated symptoms (stroke, transient ischemic attack, amaurosis fugax).Carotid atherosclerotic were collected during endarterectomy. The presence was assessed using Gomori methenamine silver staining as well anti-UA immunohistochemical quantity measured an enzymatic colorimetric assay. Clinical information obtained through retrospective review data.UA more commonly (n=23) compared (n=9) by (20 [86.9%] 2 [22.2%]; P=0.001) immunohistochemistry (16 [69.5%] 1 [11.1%]; P=0.004). higher rather than (25.1 [9.5] 17.9 [3.8] µg/g; P=0.021). Before levels (n=341) (n=146) (5.9 [interquartile range, 4.6-6.9] mg/dL 5.2 4.6-6.2] mg/dL; P=0.009).The current study supports potential role tissue participant systemic biomarker the may provide mechanistic explanation subsequent events.
Language: Английский
Citations
39
The Lancet Regional Health - Western Pacific, Journal Year: 2023, Volume and Issue: 39, P. 100848 - 100848
Published: July 27, 2023
Language: Английский
Citations
34
Analytica Chimica Acta, Journal Year: 2020, Volume and Issue: 1104, P. 69 - 77
Published: Jan. 8, 2020
Language: Английский
Citations
65
Redox Biology, Journal Year: 2021, Volume and Issue: 48, P. 102195 - 102195
Published: Nov. 24, 2021
Cardiovascular diseases (CVD) are the leading cause of global mortality and their pathogenesis lies mainly in atherosclerotic process. There close connections linking oxidative stress inflammation to endothelial dysfunction, atherosclerosis and, consequently, CVD. This review focuses on role xanthine oxidoreductase (XOR) its products development chronic stress, responsible for atheromatous plaque formation. Evidence is reported that an excessive level XOR favors inflammatory response development, thereby promoting major cardiovascular risk factors. Also, relationship between hyperuricemia hypertension as well activity CVD confirmed. In spite increasing number clinical studies investigating output patients treated with urate-lowering therapies (including uricosuric drugs, inhibitors recombinant uricase) results still uncertain. The inhibition appears more promising than just control uricemia preventing events, possibly because it also reduces intracellular accumulation urate, production reactive oxygen species. However, availability multifaced mediator nitric oxide at present, can be recommended only hyperuricemic patients.
Language: Английский
Citations
56
Cardiology Clinics, Journal Year: 2021, Volume and Issue: 39(3), P. 365 - 376
Published: July 9, 2021
Language: Английский
Citations
35
BMJ Open Respiratory Research, Journal Year: 2024, Volume and Issue: 11(1), P. e002203 - e002203
Published: March 1, 2024
Background Chronic obstructive pulmonary disease (COPD) and hyperuricaemia are both characterised by systemic inflammation. Preventing chronic diseases among the population with common metabolic abnormality is an effective strategy. However, association of higher incidence risk COPD remains controversial. Therefore, replicated researches in populations distinct characteristics or demographics compellingly warranted. Methods This cohort study adopted a design ambispective hospital-based cohort. We used propensity score matching (PSM) inverse probability treatment weighting (IPTW) to minimise effects potential confounding factors. A Cox regression model restricted cubic spline (RCS) were applied further assess effect serum urate on developing COPD. Finally, we conducted two-sample Mendelian randomisation (MR) analysis explore evidence causal association. Results There compared normal (22.29/1000 person-years vs 8.89/1000 person-years, p=0.009). result robust after performing PSM (p=0.013) IPTW (p<0.001). The confirms that associated (adjusted HR=3.35 95% CI=1.61 6.96). Moreover, RCS shows rapidly increases concentration when it than reference (420 µmol/L). MR analysis, variance weighted method evidences significant (OR=1.153, CI=1.034 1.289) likely be true. finding repeated using different methods sensitivity analysis. Conclusions Our provides convincing suggesting positive between COPD, indicates at high Chinese who seek medical advice hospital.
Language: Английский
Citations
6
Journal of Cellular and Molecular Medicine, Journal Year: 2020, Volume and Issue: 24(15), P. 8849 - 8861
Published: June 18, 2020
Abstract Uric acid crystal is known to activate the NLRP3 inflammasome and cause tissue damages, which can result in many diseases, such as gout, chronic renal injury myocardial damage. Meanwhile, soluble uric (sUA), before forming crystals, also related these diseases. This study was carried out investigate whether sUA could cardiomyocytes analyse mechanisms. The cardiomyocyte activity monitored, along with levels of mature IL‐1β caspase‐1 from H9c2 cells following stimulus. We found that able inflammasome, responsible for cell apoptosis induced by sUA. By elevating TLR6 then activating NF‐κB/p65 signal pathway, promoted NLRP3, pro‐caspase 1 pro‐IL‐1β production provided first activation. ROS regulated UCP2 contributed assembly subsequent caspase activation secretion. In addition, tlr6 knockdown rats suffering hyperuricemia showed lower level an ameliorative cardiac function. These findings suggest activates they may provide one therapeutic strategy damage
Language: Английский
Citations
36
Diabetes Research and Clinical Practice, Journal Year: 2020, Volume and Issue: 167, P. 108351 - 108351
Published: July 22, 2020
AimsCoronavirus disease (COVID-19), also referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is instigated by a novel coronavirus. The was initially reported in Wuhan, China, December 2019. Diabetes risk factor associated with adverse outcomes. Herein, our objective investigate the characteristics of laboratory findings type diabetes mellitus (T2DM) patients infected SARS-CoV-2.MethodsThis retrospective study and included 80 T2DM Jinling Hospital from 2010 2020, well 76 COVID-19 without 55 who were treated at Huoshen hill February 11 March 18, 2020. We then compared differences test results between three groups.ResultsThe levels lymphocytes, uric acid (UA), globulin group significantly higher. In contrast, C-reactive protein (CRP), creatinine, lactic dehydrogenase (LDH)levels lower than those (p < 0.05) + groups 0.05). No considerable difference observed regarding alanine aminotransferase (ALT), white blood cell (WBC), aspartate (AST), globulin, urea nitrogen (BUN) > 0.05).ConclusionT2DM SARS-CoV-2 showed decreased body mass index (BMI), UA, albumin, increased CRP levels. BMI, albumin may be oxidative stress response nutritional consumption. lymphocyte counts related infection.
Language: Английский
Citations
33
Postgraduate Medicine, Journal Year: 2024, Volume and Issue: 136(6), P. 615 - 623
Published: July 8, 2024
Serum uric acid (SUA) has garnered an increased interest in recent years as important determinant of cardiovascular disease. Uric acid, a degradation product purine metabolism, is affected by several inheritable and acquired factors, such genetic mutation, metabolic syndrome, chronic kidney disease, medication interactions. Even though elevated SUA have been commonly associated with the development gout, it significant impact hypertension, both crystalline soluble forms, plays key role induction inflammatory cascade atherosclerotic diseases. This concise reappraisal emphasizes features about complex challenging progression atherosclerosis It explores pathogenesis historical significance highlights interplay between components focuses on pro-inflammatory pro-atherogenic effects well discusses urate lowering therapies mitigating risk disease while providing latest evidence to healthcare professionals focusing clinical importance levels regards
Language: Английский
Citations
4