Metformin Contamination in Global Waters: Biotic and Abiotic Transformation, Byproduct Generation and Toxicity, and Evaluation as a Pharmaceutical Indicator

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(19), P. 13528 - 13545

Published: Sept. 15, 2022

Metformin is the first-line antidiabetic drug and one of most prescribed medications worldwide. Because its ubiquitous occurrence in global waters demonstrated ecotoxicity, metformin, as with other pharmaceuticals, has become a concerning emerging contaminant. subject to transformation, producing numerous problematic transformation byproducts (TPs). The occurrence, removal, toxicity metformin have been continually reviewed; yet, comprehensive analysis pathways, byproduct generation, associated change adverse effects lacking. In this review, we provide critical overview fate during water treatments natural processes compile 32 organic TPs generated from biotic abiotic pathways. These occur aquatic systems worldwide along metformin. Enhanced several compared through organism tests necessitates development complete mineralization techniques for more attention on TP monitoring. We also assess potential indicate overall contamination pharmaceuticals environments, previously acknowledged ones, found be robust or comparable indicator such pharmaceutical contamination. addition, insightful avenues future research

Language: Английский

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Contaminant Exposure and Transport from Three Potential Reuse Waters within a Single Watershed

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(3), P. 1353 - 1365

Published: Jan. 10, 2023

Global demand for safe and sustainable water supplies necessitates a better understanding of contaminant exposures in potential reuse waters. In this study, we compared load contributions to surface from the discharge three waters (wastewater effluent, urban stormwater, agricultural runoff). Results document substantial varying organic-chemical contribution effluent discharges (e.g., disinfection byproducts [DBP], prescription pharmaceuticals, industrial/household chemicals), stormwater polycyclic aromatic hydrocarbons, pesticides, nonprescription pharmaceuticals), runoff pesticides). Excluding DBPs, episodic storm-event organic concentrations loads were comparable often exceeded those daily wastewater-effluent discharges. We also assessed if irrigation corn resulted measurable effects on rain-induced harvested feedstock. Overall, target-organic 491 g study field during 2019 growing season did not produce dissolved organic-contaminant subsequent events. Out 140 detected organics source irrigation, only imidacloprid estrone had that observable differences between effluent-irrigated nonirrigated fields. Analyses pharmaceuticals per-/polyfluoroalkyl substances at-harvest corn-plant samples two antibiotics, norfloxacin ciprofloxacin, at 36 70 ng/g, respectively, samples; no contaminants noneffluent irrigated samples.

Language: Английский

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Daily Monitoring at a Full-Scale Wastewater Treatment Plant Reveals Temporally Variable Micropollutant Biotransformations

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(28), P. 10404 - 10414

Published: July 5, 2023

Despite decades of micropollutant (MP) monitoring at wastewater treatment plants (WWTPs), we lack a fundamental understanding the time-varying metabolic processes driving MP biotransformations. To address this knowledge gap, collected 24-h composite samples from influent and effluent conventional activated sludge (CAS) process WWTP over 14 consecutive days. We used liquid chromatography high-resolution mass spectrometry to (i) quantify 184 MPs in CAS process; (ii) characterize temporal dynamics removal biotransformation rate constants; (iii) discover biotransformations linked temporally variable constants. measured 120 least one sample 66 every sample. There were 24 exhibiting throughout sampling campaign. hierarchical clustering analysis reveal four trends constants found with specific structural features co-located clusters. screened our HRMS acquisitions for evidence among MPs. Our analyses that alcohol oxidations, monohydroxylations secondary or tertiary aliphatic carbons, dihydroxylations vic-unsubstituted rings, unsubstituted rings are exhibit variability on daily timescales.

Language: Английский

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Advancements in the dominion of fate and transport of pharmaceuticals and personal care products in the environment—a bibliometric study

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(23), P. 64313 - 64341

Published: April 17, 2023

Language: Английский

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Laboratory measurements underestimate persistence of the aquatic herbicide fluridone in lakes

Environmental Science Processes & Impacts, Journal Year: 2024, Volume and Issue: 26(2), P. 368 - 379

Published: Jan. 1, 2024

Laboratory measurements overpredict the susceptibility of herbicide fluridone to bio- and photodegradation compared in lakes.

Language: Английский

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Presence, Removal, and Risks of Psychopharmaceuticals in Wastewater Streams

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: 44(2), P. 375 - 385

Published: Jan. 6, 2025

Psychopharmaceuticals are used to treat psychological disorders and other conditions relating the nervous system known affect nontarget organisms at low concentrations. Their occurrence in water cycle remains an understudied topic, with data lacking for many compounds, risks not accounted removal targets. Therefore, this study aimed provide insights into presence, removal, of psychopharmaceuticals wastewater. Furthermore, use risk assessment context proposed legislation is discussed. Thirty highly were studied during 1 week wastewater Amsterdam West Wastewater Treatment Plant (WWTP) using solid phase extraction ultra high performance liquid chromatography-quadrupole time flight-high resolution mass spectrometry. Twenty target compounds detected influent (17 ng-99 µg/L) 16 effluent (34 ng/L-17 µg/L). Removal efficiencies treatment ranged from 24% >99%. Paracetamol, amphetamine, fluoxetine, levetiracetam, phenacetin, sertraline demonstrated almost complete whereas tramadol, lidocaine, lamotrigine, fluvoxamine, carbamazepine had removals below 50%, lidocaine demonstrating lowest (24%). Utilizing existing ecotoxicity data, a preliminary was performed contextualize calculated efficiencies. Here, ibuprofen still potential risk, despite both compounds. This highlights that contains abundant numbers ecotoxicologically relevant concentrations insufficiently removed by WWTP. The implementation risk-based targets discussed facilitate reduction emissions psychopharmaceuticals, example, adequate WWTP upgrades advanced treatments ensure toxic-free environment.

Language: Английский

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Synthesizing Laboratory and Field Experiments to Quantify Dominant Transformation Mechanisms of 2,4-Dichlorophenoxyacetic Acid (2,4-D) in Aquatic Environments

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(15), P. 10838 - 10848

Published: July 20, 2022

Laboratory studies used to assess the environmental fate of organic chemicals such as pesticides fail replicate conditions, resulting in large errors predicted transformation rates. We combine laboratory and field data identify dominant loss processes herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) lakes for first time. Microbial photochemical degradation are individually assessed using laboratory-based microcosms irradiation studies, respectively. Field campaigns conducted six quantify 2,4-D following large-scale treatments. Irradiation show that undergoes direct photodegradation, but modeling efforts demonstrated this process is negligible under conditions. Microcosms constructed inocula sediment microbial communities responsible lakes. Attempts products unsuccessful both suggesting their persistence not a major concern. The synthesis experiments demonstrate best practices designing those results mechanistically predict contaminant complex aquatic environments.

Language: Английский

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Wastewater Deterministically Impacts the Composition and Assembly of Planktonic Microorganisms in the River Ecosystem

ACS ES&T Water, Journal Year: 2024, Volume and Issue: 4(2), P. 388 - 398

Published: Jan. 25, 2024

Bacteria and microeukaryotes inhabiting urban freshwater are susceptible to environmental disturbance, particularly effluents from wastewater treatment plants (WWTPs). However, how riverine microbial community succession responds WWTP effluent its assembly processes remains poorly addressed. Herein, surface water samples were collected an river explore the dynamics under impact of effluent. Physicochemical property variation (e.g., total phosphorus nitrate concentration) caused by was more strongly correlated with than geographic distance. Importantly, deterministic increase 34.8 93.3% for bacterial upstream downstream. Betaproteobacteria, Bacillariophyta, Chlorophyceae exhibited essential roles in mediating composition against discharge. In addition, bacteria tend have a stronger interaction wet or normal periods, while may stable networks dry periods. Seasonal significant discrepancy (ANOVA P = 0.001) both microeukaryotes. Our work provides systematic information on treated contributes identifies potential keystone taxa during response wastewater, which lead improved management discharge health.

Language: Английский

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Revealing the underestimated risks of pharmaceutical transformation products in wastewater by suspect and targeted screening

Water Research, Journal Year: 2025, Volume and Issue: 276, P. 123265 - 123265

Published: Feb. 14, 2025

Language: Английский

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Impact of the wastewater treatment technology and storage on micropollutant profiles during reclaimed water irrigation: A wide-scope HRMS screening in a water-soil-lettuce-leachate system

Water Research, Journal Year: 2025, Volume and Issue: 279, P. 123319 - 123319

Published: Feb. 18, 2025

Language: Английский

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