Toxics,
Journal Year:
2023,
Volume and Issue:
11(8), P. 706 - 706
Published: Aug. 16, 2023
The
presence
of
contaminants
in
the
environment
has
increased
recent
years,
and
studies
have
demonstrated
that
these
ability
to
penetrate
blood–retinal
barrier
directly
affect
visual
systems
organisms.
Zebrafish
are
recognized
as
an
ideal
model
for
human
eye
diseases
due
their
anatomical
functional
similarities
eye,
making
them
efficient
versatile
organism
studying
ocular
toxicity
caused
by
environmental
field
toxicology.
Meanwhile,
zebrafish
exhibit
a
diverse
repertoire
visually
mediated
behaviors,
system
undergoes
complex
changes
behavioral
responses
when
exposed
contaminants,
enabling
rapid
assessment
induced
such
pollutants.
Therefore,
this
review
aimed
highlight
effectiveness
examining
effects
on
development.
Special
attention
is
given
behavior
zebrafish,
which
allows
resulting
from
exposure
contaminants.
Additionally,
potential
mechanisms
may
induce
briefly
outlined.
The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
874, P. 162406 - 162406
Published: Feb. 23, 2023
Nanoplastics
(NP)
are
present
in
aquatic
and
terrestrial
ecosystems.
Humans
can
be
exposed
to
them
through
contaminated
water,
food,
air,
or
personal
care
products.
Mechanisms
of
NP
toxicity
largely
unknown
the
Zebrafish
embryo
poses
an
ideal
model
investigate
due
its
high
homology
with
humans.
Our
objective
study
was
combine
a
battery
behavioral
assays
endocrine
related
gene
expression,
further
explore
potential
neurotoxic
effects
on
animal
behavior.
Polystyrene
nanoplastics
(PSNP)
were
used
evaluate
toxicity.
neurobehavioral
profiles
include
tail
coiling
assay,
light/dark
activity
two
thigmotaxis
anxiety
(auditory
visual
stimuli),
startle
response
-
habituation
assay
auditory
stimuli.
Results
show
PSNP
accumulated
eyes,
neuromasts,
brain,
digestive
system
organs.
inhibited
acetylcholinesterase
altered
endocrine-related
expression
both
thyroid
glucocorticoid
axes.
At
whole
organism
level,
we
observed
behaviors
such
as
increased
at
lower
doses
lethargy
higher
dose,
which
could
variety
complex
mechanisms
ranging
from
sensory
organ
central
nervous
others
hormonal
imbalances.
In
addition,
hypothetical
adverse
outcome
pathway
these
effects.
conclusion,
this
provides
new
understanding
into
toxic
zebrafish
embryo,
emphasizing
critical
role
disruption
effects,
improving
our
their
health
risks
human
populations.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(3), P. 178 - 178
Published: Feb. 26, 2024
The
escalating
prevalence
of
microplastics
and
nanoplastics
in
aquatic
environments
is
a
major
challenge
affecting
the
behavior
reproductive
health
organisms
while
posing
potential
risks
to
human
ecosystems.
This
review
focuses
on
neurobehavioral
changes
toxicity
MNPs
zebrafish
their
relationships.
At
same
time,
caused
by
were
studied,
synergistic
effects
interaction
these
pollutants
with
other
environmental
contaminants
explored.
In
addition,
zebrafish,
as
model
organism,
provide
valuable
insights
into
subtle
but
important
behavior,
which
critical
for
understanding
success,
suggesting
that
behavioral
can
serve
an
early
biomarker
toxicity.
based
classical
endocrine
disruptor
models
research
methods,
current
status
was
reviewed,
further
indicated
parameters
be
used
effective
rapid
tool
evaluate
MNPs.
However,
methods
rapidly
assessing
are
still
area
exploration.
To
address
limitations
challenges
scope
research,
this
outlines
future
directions
aim
improving
our
impacts
work
aims
inform
targeted
policies
advance
public
strategies
growing
pollution.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(2), P. 160 - 160
Published: Feb. 18, 2024
Diflubenzuron
(DFB)
and
pyriproxyfen
(PPF)
are
larvicides
used
in
crops
to
control
insect
plagues.
However,
these
pesticides
known
impact
non-target
organisms
like
fish
mammals.
Here,
we
aimed
at
assessing
the
embryotoxicity
of
purified
DFB,
PPF,
their
mixtures
a
organism—zebrafish.
Zebrafish
embryos
were
exposed
different
concentrations
for
120
h:
0.025,
0.125,
0.25,
1.25,
2.5,
10
mg/L
PPF
while
0.025
+
DFB
(Mix
A),
0.125
B),
0.25
C)
DFB.
We
observed
mortality,
teratogenicity,
cardiotoxicity.
For
neurotoxicity
tests
evaluation
reactive
oxygen
species
(ROS)
levels
brain,
h
0.379
0.754
established
LC50
as
3.79
mg/L,
was
not
determinable.
Survival
hatching
affected
by
above
1.25
lower
pesticide
mixtures.
exposure
induced
types
malformations,
higher
number
malformations
mixtures,
suggesting
potentiating
effect.
Pesticides
diminished
avoidance
responses
increased
ROS
across
all
concentrations,
indicating
neurotoxicity.
Our
findings
underscore
detrimental
exposure,
spanning
from
biochemistry
morphology.
There
is
critical
need
reconsider
global
use
transition
more
ecologically
friendly
forms
pest
control,
raising
an
alarm
regarding
repercussions
on
human
animal
health
well-being.
