Aquatic photolysis of high-risk fluorinated liquid crystal monomers: Kinetics, toxicity evaluation, and mechanisms

Water Research, Journal Year: 2024, Volume and Issue: 255, P. 121510 - 121510

Published: March 23, 2024

Language: Английский

---

A method for the determination of 60 liquid crystal monomers in biotic and abiotic samples

Environmental Chemistry and Ecotoxicology, Journal Year: 2024, Volume and Issue: 6, P. 51 - 64

Published: Jan. 1, 2024

Liquid crystal monomers (LCMs) are synthetic organic chemicals widely used in the manufacture of liquid displays (LCDs) digital electronic devices. As human interactions with electronics like computers and cell phones intensify, exposure to LCMs is concern. Nevertheless, there limited research on occurrence biological non-biological matrices. We developed a method determine 60 electronic-waste panels, indoor dust, feces, urine using gas chromatography–mass spectrometry (GC–MS). Solid matrices (i.e., dust feces) were extracted solid-liquid extraction (SLE) whereas urine) solid phase (SPE). Indoor feces extracts purified by passage through silica gel packed gravity columns. The instrument limits detection (LODs) quantification (LOQs) ranges 0.05–13.0 0.18–39.1 ng/mL, respectively. Recoveries all target analytes fortified at concentrations 10 100 ng/mL LCD range 71.1–130%, standard deviations 0.01–33%. Repeated analyses similarly samples yielded intra-day inter-day variations (CV) 0.32–12.6% 0.76–14.3%, Matrix effects, calculated from matrices, ranged −28.5% 28.5%. was applied analysis dog urine, which found contain 22, 42, 46, 18 targeted LCMs, panels (∑LCM = 1780 ± 165 ng/cm2 for desktop computer monitors; 166,900 80,100 smartphone screens), 2030 1260 ng/g), 1990 2000 ng/g dw), 24.0 14.6 ng/mL). can be wide environmental samples.

Language: Английский

---

A new class of contaminants of concern? A comprehensive review of liquid crystal monomers

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174443 - 174443

Published: July 2, 2024

Liquid crystal monomers (LCMs) are a class of emerging contaminants concern predicted to be persistent, bioaccumulative and toxic (PBT). Being one the key components in liquid displays (LCDs), disposal LCD containing devices is closely related emission LCMs into environment. have been detected wide range environmental matrices including dust, sediment, soil, sewage leachate, air, with concentration ranges between 17 2121 ng/g found indoor residential dust. Furthermore, they on human skin at concentrations up 2,071,000 ng/m

Language: Английский

---

Particle size-dependent and route-specific exposure to liquid crystal monomers in indoor air: Implications for human health risk estimations

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168328 - 168328

Published: Nov. 4, 2023

Language: Английский

---

Analysis of 78 trace liquid crystal monomers in air by gas chromatography coupled with triple quadrupole mass spectrometry

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 928, P. 172459 - 172459

Published: April 12, 2024

Language: Английский

---

Integrative molecular and physiological insights into the phytotoxic impact of liquid crystal monomer exposure and the protective strategy in plants

Plant Biotechnology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Summary Liquid crystal monomers (LCMs), the integral components in manufacture of digital displays, have engendered environmental concerns due to extensive utilization and intensive emission. Despite their prevalence ecotoxicity, LCM impacts on plant growth agricultural yield remain inadequately understood. In this study, we investigated specific response mechanisms tobacco, a pivotal crop model plant, four representative LCMs (2OdF3B, 5CB, 4PiMeOP, 2BzoCP) through integrative molecular physiological approaches. The findings reveal impacts, with 4PiMeOP exerting most pronounced effects, followed by 2BzoCP, 2OdF3B. exposure disrupts photosynthetic apparatus, exacerbating reactive oxygen species (ROS) levels leaves, which turn triggers upregulation antioxidative enzymes synthesis antioxidant substances. Additionally, strongly stimulate expression genes involved abscisic acid (ABA) biosynthesis signalling pathways. AI‐assisted meta‐analysis implicates ABA as critical regulator tobacco LCMs. Notably, exogenous application alleviates LCM‐induced toxicities, highlighting role stress amelioration. Our study provides novel insights into toxicity tolerance plants, shedding light both harmful effects ecosystems potential adaptation responses. This is crucial develop sustainable systems reducing negative caused emerging organic pollutants.

Language: Английский

---

Hepatotoxicity of Three Common Liquid Crystal Monomers in Mus musculus: Differentiation of Actions Across Different Receptors and Pathways

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Liquid crystal monomers (LCMs) of different chemical structures were widely detected in various environmental matrices. However, their health risk evaluation is lacking. Herein, three representative LCMs selected from 74 LCM candidates upon literature review and acute cytotoxicity evaluation, then Mus musculus exposed to the for 42 days at doses 0.5 50 μg/kg/d investigate hepatotoxicity mechanisms. Phenotypic histopathological results showed that (DTMDPB, MeO3bcH, 5OCB) induced hepatomegaly, only 5OCB fatty liver. DTMDPB MeO3bcH decreased total cholesterol (TCHO) triglyceride (TG) content, whereas increased TCHO, TG, alanine aminotransferase levels. Transcriptome molecular docking analysis revealed by agonizing farnesoid X receptor, resulting disruption unsaturated acid biosynthesis, ascorbic antioxidant pathways, circadian clock homeostasis. promoted inflammation altered acid, primary bile rhythm antagonizing aryl hydrocarbon receptor. antagonized peroxisome proliferator-activated receptors, leading liver caused steroid, cholesterol, terpenoid backbone biosynthesis pathways. This study provides references understanding with selection priority control LCMs.

Language: Английский

---

CytoToxLCM: A Software to Predict Cytotoxicity of Emerging Contaminant Liquid Crystal Monomers

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

Liquid crystal monomers (LCMs) have emerged as a new class of contaminants, yet their health risks remain unclear due to limited toxicity data. This study assessed 46 structurally diverse LCMs using primary mouse hepatocytes, revealing significant cytotoxicity in 22 compounds, particularly 3OCB, tFMeO-3cHtFT, 2OdF3B, 2O2cHdFB, and 2CB. To predict across thousands reported LCMs, classification models quantitative structure-activity relationship (QSAR) were developed. For five optimal models, sensitivity, specificity, prediction accuracy for the respective training validation sets >0.900. In terms prediction, we established k-nearest neighbor-based QSAR model, its coefficient determination (R2), leave-one-out cross-validation Q2 (Q2LOO), externally explained variance (Q2EXT), concordance correlation (CCC) all greater than 0.850. These integrated into CytoToxLCM software, enabling high-throughput screening 1127 LCMs. The results virtual showed that over 40% predicted be cytotoxic, with fluorinated ranking most toxic. this are reliable predicting or untested aiding better understanding potential hepatotoxic effects contributing design safer industrial application alternatives.

Language: Английский

---

The role of pyroptosis in environmental pollutants-induced multisystem toxicities

Life Sciences, Journal Year: 2025, Volume and Issue: 372, P. 123632 - 123632

Published: April 10, 2025

Language: Английский

---

Socio-environmental externalities of sewage waste management

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 945, P. 174109 - 174109

Published: June 21, 2024

Language: Английский

---