Metagenomic sequencing reveals the mechanism for inhibiting N2O production in PN systems with long-term exposure to PPCPs DOI
Yuren Wang, Lu Li, Yikun Hu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158144 - 158144

Published: Dec. 1, 2024

Language: Английский

Metagenomics unveils the role of hospitals and wastewater treatment plants on the environmental burden of antibiotic resistance genes and opportunistic pathogens DOI Creative Commons
Reshma Silvester, William Bernard Perry, Gordon Webster

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 961, P. 178403 - 178403

Published: Jan. 1, 2025

Antimicrobial resistance (AMR) is a global health challenge, with hospitals and wastewater treatment plants (WWTPs) serving as significant pathways for the dissemination of antibiotic genes (ARGs). This study investigates potential wastewater-based epidemiology (WBE) an early warning system assessing burden AMR at population level. In this comprehensive year-long study, effluent was collected weekly from three large hospitals, treated untreated were monthly associated community WWTPs. Metagenomic analysis revealed significantly higher relative abundance diversity ARGs in hospital than Notably, conferring to clinically antibiotics such β-lactams, aminoglycosides, sulfonamides, tetracyclines more prevalent effluents. Conversely, rifampicin MLS (macrolides-lincosamide-streptogramin) commonly detected WWTPs, particularly effluent. Network identified bacterial hosts, which are key carriers these ARGs. The further highlighted variability ARG removal efficiencies across none achieving complete elimination or reduction diversity. Additionally, profiles remained relatively consistent throughout indicating persistent release baseload pathogenic bacteria into surface waters, potentially polluting aquatic environments entering food chain. underscores need routine WBE surveillance, enhanced strategies, hospital-level source control measures mitigate environment.

Language: Английский

Citations

1
The fate of antibiotic resistance genes and their correlation with microbial communities and wastewater quality/parameters in a wastewater treatment plant under different seasons DOI

Heyun Yang,

Xiaolin Li, Xiaoliang Li

et al.

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 60, P. 105156 - 105156

Published: March 18, 2024

Language: Английский

Citations

6
Profiles of phage in global hospital wastewater: Association with microbial hosts, antibiotic resistance genes, metal resistance genes, and mobile genetic elements DOI
Yutong Kang, Jie Wang,

Yuan Wang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171766 - 171766

Published: March 19, 2024

Language: Английский

Citations

4
Accelerated dissemination of antibiotic resistant genes via conjugative transfer driven by deficient denitrification in biochar-based biofiltration systems DOI

Lecheng Wei,

Yutong Han,

Jingjing Zheng

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 934, P. 173268 - 173268

Published: May 14, 2024

Language: Английский

Citations

4
Metagenomic analysis of viral community during different municipal solid waste collection and treatment processes: Fate, hosts, and antibiotic resistance genes DOI
Yanyan Guo, Youcai Zhao, Kunsen Lin

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137520 - 137520

Published: Feb. 7, 2025

Language: Английский

Citations

0
Metagenomics reveals rare and abundant resistome had different resistance and transmission risk in park environment DOI Creative Commons
Jie Bi,

Xueying Gan,

Chenwei Shi

et al.

Environmental Technology & Innovation, Journal Year: 2025, Volume and Issue: unknown, P. 104112 - 104112

Published: Feb. 1, 2025

Language: Английский

Citations

0
Neglected role of virus-host interactions driving antibiotic resistance genes reduction in an urban river receiving treated wastewater DOI
Xiaojie Yan, Yuan Xin, Liying Zhu

et al.

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123627 - 123627

Published: April 1, 2025

Language: Английский

Citations

0
Sludge biolysis pretreatment to reduce antibiotic resistance genes (ARGs): Insight into the relationship between potential ARGs hosts and BALOs' preferred prey DOI
Siyuan Zhang, Tingting Cui, Xinchang Liu

et al.

Water Research, Journal Year: 2024, Volume and Issue: 260, P. 121949 - 121949

Published: June 15, 2024

Language: Английский

Citations

3
Industrialization drives the gut microbiome and resistome of the Chinese populations DOI Creative Commons
Tian Chen, Tongzuo Zhang,

Daohua Zhuang

et al.

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

ABSTRACT Industrialization has driven lifestyle changes in eastern and western Chinese populations, yet we have a poor understanding of the dynamic their gut microbiome resistome under industrialization, which is essential for scientific management public health. Here, this study employed metagenomics to analyze microbiota 1,382 healthy individuals from China, including 415 region advanced industrialization 967 developing industrialization. Compared with populations show significant increase interindividual dissimilarity microbial species composition metabolic pathways but decrease intraindividual functional diversity. Furthermore, our results found significantly less abundance richness antibiotic resistance genes (ARGs) alongside lower prevalence unique core ARG subtypes. For 12 types shared between mean relative two was notably higher while eight had populations. Based on reconstruction metagenomic assembled genomes, that Escherichia coli genomes carried more virulence factor (VFGs) mobile genetic elements (MGEs) compared those This large-scale first time revealed potentially led unexpected alterations provide vital implication health may aid development region-specific strategies managing pathogenic infections. IMPORTANCE As China experiences rapid uneven its effect people’s bacteria critical reveals how reshape risks related resistance. work provides crucial information help create customized policies different regions.

Language: Английский

Citations

0
Genetic diversity of dissolved free extracellular DNA compared to intracellular DNA in wastewater treatment plants DOI Creative Commons

Soichiro Tamai,

Miki Okuno, Yoshitoshi Ogura

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 970, P. 178989 - 178989

Published: March 1, 2025

Dissolved free extracellular DNA (free-exDNA) coexists with intracellular (inDNA) in aquatic environments. Free-exDNA can be taken up by bacteria through transformation, and wastewater treatment plants (WWTPs) are positioned as potential hot spots for genetic contamination. However, studies comparing the composition of free-exDNA inDNA is limited. This study employed colloidal adsorption foam concentration method to recover from different WWTP stages compared its diversity via metagenomic analysis. concentrations were observed increase after chlorination. Genetic analysis revealed a higher abundance specific genes following chlorination, suggesting that effluent originated bacterial death secondary treated water. result indicates free-exDNA, which increases due subsequently released into catchment. Additionally, several high-risk antibiotic-resistance (ARGs) detected colocalized mobile elements. These ARGs expected have high gene transfer risk was highlighted. Overall, these findings deepen our understanding horizontal risks WWTPs.

Language: Английский

Citations

0