Published: Jan. 1, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 18, 2024
Introduction A group of SARS-CoV-2 infected individuals present lingering symptoms, defined as long COVID (LC), that may last months or years post the onset acute disease. portion LC patients have symptoms similar to myalgic encephalomyelitis chronic fatigue syndrome (ME/CFS), which results in a substantial reduction their quality life. better understanding pathophysiology LC, particular, ME/CFS is urgently needed. Methods We identified and studied metabolites soluble biomarkers plasma from mainly exhibiting compared age-sex-matched recovered (R) without COVID-19 (A), unexposed healthy (HC). Results Through these analyses, we alterations several metabolomic pathways vs other groups. Plasma metabolomics analysis showed differed R HC Of note, also exhibited different profile than HC. Moreover, observed significant elevation pro-inflammatory (e.g. IL-1α, IL-6, TNF-α, Flt-1, sCD14) but ATP patients. Our demonstrate exhibit persistent abnormalities 12 after such can be Hence, recovery period for with might long-lasting. In found sarcosine serine concentrations patients, was inversely correlated depression, anxiety, cognitive dysfunction scores. Conclusion study findings provide comprehensive knowledge base suggests supplementations potential therapeutic implications Finally, our reveals disproportionally affects females more males, evidenced by nearly 70% being female.
Language: Английский
Citations
33
Seminars in Immunology, Journal Year: 2024, Volume and Issue: 72, P. 101873 - 101873
Published: March 1, 2024
Language: Английский
Citations
14
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 24, 2025
Language: Английский
Citations
1
Molecular Diagnosis & Therapy, Journal Year: 2024, Volume and Issue: 28(5), P. 537 - 574
Published: Aug. 5, 2024
Language: Английский
Citations
5
Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(773)
Published: Nov. 13, 2024
Long Covid is defined by a wide range of symptoms that persist after the acute phase severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other reported. Symptom range, duration, severity are highly variable partially overlap myalgic encephalomyelitis/chronic fatigue post-acute infectious syndromes, highlighting opportunities to define shared mechanisms pathogenesis. Potential diverse, including persistence viral reservoirs, dysregulated immune responses, direct damage tissues targeted SARS-CoV-2, inflammation driven reactivation latent infections, vascular endothelium activation or subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, microbiota dysbiosis. The heterogeneity baseline characteristics people Covid, as well varying states immunity therapies given at time infection, have made etiologies difficult determine. Here, we examine progress on preclinical models for review being in clinical trials, need large human studies further development better understand Covid. Such will inform trials treatments benefit those living this condition.
Language: Английский
Citations
4
Frontiers in Systems Biology, Journal Year: 2025, Volume and Issue: 4
Published: Jan. 7, 2025
Post-Acute Sequelae of SARS-CoV-2 infection (PASC or “Long COVID”), includes numerous chronic conditions associated with widespread morbidity and rising healthcare costs. PASC has highly variable clinical presentations, likely multiple molecular subtypes, but it remains poorly understood from a mechanistic standpoint. This hampers the development rationally targeted therapeutic strategies. The NIH-sponsored “Researching COVID to Enhance Recovery” (RECOVER) initiative several retrospective/prospective observational cohort studies enrolling adult, pregnant adult pediatric patients respectively. RECOVER formed an “OMICS” multidisciplinary task force, including clinicians, pathologists, laboratory scientists data scientists, charged developing recommendations apply cutting-edge system biology technologies achieve goals RECOVER. force met biweekly over 14 months, evaluate published evidence, examine possible contribution each “omics” technique study develop design recommendations. OMICS recommended integrated, longitudinal, simultaneous systems participant biospecimens on entire cohorts through centralized laboratories, as opposed smaller using one few analytical techniques. resulting multi-dimensional dataset should be correlated deep phenotyping performed RECOVER, well information demographics, comorbidities, social determinants health, exposome lifestyle factors that may contribute presentations PASC. approach will minimize lab-to-lab technical variability, maximize sample size for class discovery, enable incorporation many relevant variables into statistical models. Many our have already been considered by NIH peer-review process, in creation panel is currently designing we proposed. strategy, coupled modern science approaches, dramatically improve prospects accurate disease subtype identification, biomarker discovery target identification precision treatment. made available scientific community secondary analyses. Analogous approaches built designs large whenever possible.
Language: Английский
Citations
0
Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Long coronavirus disease (COVID) is defined as the continuation or development of new symptoms three months after severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and that last for at least two months, with no other explanation their cause. This includes various clinical manifestations affect multiple organ systems, such complications in respiratory, cardiovascular, neurological, musculoskeletal systems. The most commonly reported include fatigue, cognitive dysfunction, dyspnea, chest pain; however, prevalence severity these vary greatly among individuals. underlying mechanisms long COVID are complex multifaceted, encompassing viral persistence, immune system mitochondrial abnormalities, endothelial impairment, alterations microbiome. Further, has imposed a significant burden on individuals, healthcare economy by impairing an individual’s quality life functional capacity, thereby increasing costs demand care rehabilitation services. review summarizes definition, phenotypes, mechanisms, current treatment advancements highlights specific research directions future investigation.
Language: Английский
Citations
0
BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 5, 2025
Approximately 10-30% of individuals continue to experience symptoms classified as post-acute sequelae coronavirus disease 2019 (COVID-19 (PASC)). PASC is a multisystem condition primarily characterized by respiratory symptoms, such reduced diffusing capacity for carbon monoxide (DLco). Although many studies have investigated the pathogenesis acute COVID-19, long-term molecular changes in COVID-19 convalescents with remain poorly understood. We prospectively recruited 70 who had been diagnosed from 7 January 2020 29 May (i.e., convalescents); we performed follow-up visits at 6 months, 1 year, 2 years, and 3 years after hospital discharge. Thirty-five healthy controls (CONs), physical examination center before pandemic, served comparison group. explored proteomic metabolomic profiles 174 plasma samples 35 CONs. comprehensive analysis investigate host up Our multi-omics revealed activation cytoskeletal organization glycolysis/gluconeogenesis, well suppression gas transport adaptive immune responses, convalescents. Additionally, metabolites involved glutathione metabolism; alanine, aspartate, glutamate ascorbate aldarate metabolism were significantly upregulated Pulmonary abnormalities persisted convalescents; impaired (DLco) was most prominent feature. used this profile develop model involving one protein (heterogeneous nuclear ribonucleoprotein K (HNRNPK)) two (arachidonoyl-EA 1-O-(2r-hydroxy-pentadecyl)-sn-glycerol)) identification abnormal DLco. These data provide insights concerning among discharge, clarify mechanisms driving sequelae, support development novel predict This longitudinal may illuminate trajectory altered lung function
Language: Английский
Citations
0
Allergy, Journal Year: 2025, Volume and Issue: unknown
Published: March 14, 2025
ABSTRACT An estimated 10% of coronavirus disease (COVID‐19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. This systematic review (PROSPERO: CRD42024499281) aimed explore the pathophysiological mechanisms underlying LC and potential treatable traits across symptom‐based phenotypes. We included studies with primary data, written in English, focusing on omics analyses human samples patients persistent at least 3 months. Our search PubMed Embase, conducted January 8, 2024, identified 642 studies, 29 met inclusion criteria after full‐text assessment. The risk bias was evaluated using Joanna Briggs Institute appraisal tool. synthesis including genomics, transcriptomics, proteomics, metabolomics, metagenomics, revealed common findings associated fatigue, cardiovascular, pulmonary, neurological, gastrointestinal Key mitochondrial dysfunction, dysregulated microRNAs pulmonary tissue impairment, blood–brain barrier disruption, coagulopathy, vascular microbiome disturbances, microbial‐derived metabolite production inflammation. Limitations include cross‐study heterogeneity variability sampling methods. emphasizes complexity need further longitudinal omics‐integrated advance development biomarkers targeted treatments.
Language: Английский
Citations
0
Phenomics, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0