Tertiary lymphoid structure formation: A matter of tumor-immune co-evolution DOI
Anne M. van der Leun

Molecular Immunology, Journal Year: 2024, Volume and Issue: 175, P. 143 - 145

Published: Oct. 9, 2024

Language: Английский

Tertiary lymphoid structures in anticancer immunity DOI
Jean‐Luc Teillaud, Ana Houel, Marylou Panouillot

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(9), P. 629 - 646

Published: Aug. 8, 2024

Language: Английский

Citations

30
Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer DOI Creative Commons
Wei‐Yi Chen, Lingli Zhang,

Man Gao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Gastric cancer is a common malignant tumor of the digestive tract, and its treatment remains significant challenge. In recent years, role various immune cells in microenvironment progression has gained increasing attention. Immunotherapy, primarily based on checkpoint inhibitors, notably improved prognosis patients with gastric cancer; however, challenges regarding therapeutic efficacy persist. Histological features within microenvironment, such as tertiary lymphoid structures (TLSs), tumor-infiltrating lymphocytes, proportion intratumoral stroma, are emerging potentially effective prognostic factors. cancer, TLSs may serve local hubs, enhancing ability to interact recognize antigens, which closely linked effectiveness immunotherapy survival rates patients. However, specific cell type driving TLS formation tumors not yet been elucidated. Mature B-cell regions containing germinal centers. During center formation, B undergo transformations become mature function, exerting anti-tumor effects. Therefore, targeting could provide new avenues for immunotherapy. This review, combined current research elaborates relationship between aiming guidance precise

Language: Английский

Citations

2
Tertiary lymphoid structures and cancer immunotherapy: From bench to bedside DOI Creative Commons
Florent Peyraud, Jean‐Philippe Guégan, Lucile Vanhersecke

et al.

Med, Journal Year: 2025, Volume and Issue: 6(1), P. 100546 - 100546

Published: Jan. 1, 2025

Language: Английский

Citations

2
Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances DOI Creative Commons
Lianyu Zhao,

Song Jin,

Shengyao Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 28, 2024

Tertiary lymphoid structures (TLSs) are defined as aggregates formed in non-hematopoietic organs under pathological conditions. Similar to secondary (SLOs), the formation of TLSs relies on interaction between tissue inducer (LTi) cells and organizer (LTo) cells, involving multiple cytokines. Heterogeneity is a distinguishing feature TLSs, which may lead differences their functions. Growing evidence suggests that associated with various diseases, such cancers, autoimmune transplant rejection, chronic inflammation, infection, even ageing. However, detailed mechanisms behind these clinical associations not yet fully understood. The by TLS maturation localization affect immune function also unclear. Therefore, it necessary enhance understanding development at cellular molecular level, allow us utilize them improve microenvironment. In this review, we delve into composition, mechanism, potential therapeutic applications TLSs. Furthermore, discuss implications role markers response prognosis. Finally, summarize methods for detecting targeting Overall, provide comprehensive aim develop more effective strategies.

Language: Английский

Citations

15
T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle DOI Creative Commons
Wen‐Ping Lin, Hao Li, Zhi‐Jun Sun

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 104, P. 105154 - 105154

Published: May 14, 2024

Language: Английский

Citations

9
Mature tertiary lymphoid structures: important contributors to anti-tumor immune efficacy DOI Creative Commons

Xinyu Bao,

Xuwen Lin,

Mei Xie

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

Tertiary lymphoid structures (TLS) represent the ectopic aggregations of immune cells arising during chronic inflammation or tumor progression. In cancer, TLS are often associated with beneficial clinical outcomes in patients undergoing immunotherapy, underscoring their prognostic and predictive significance. Mature TLS, characterized by germinal centers areas T-cell B-cell aggregation, considered primary locations for activating maintaining both humoral cellular anti-tumor effects. Despite recognized importance, mechanisms driving formation mature cancer influence on response within tumors remain insufficiently understood. Therefore, this review aims to comprehensively explore structural composition, development mechanisms, maturity impact factors, immunological function, innovative therapeutic strategies microenvironment. The research summarized herein offers novel insights considerations approaches promote generation maturation representing a promising avenue future therapies.

Language: Английский

Citations

5
Emerging strategies to investigate the biology of early cancer DOI
Ran Zhou, Xiwen Tang, Yuan Wang

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(12), P. 850 - 866

Published: Oct. 21, 2024

Language: Английский

Citations

5
A reappraisal of IL-9 in inflammation and cancer DOI Creative Commons
Fabian Bick, Christophe Blanchetot, Bart N. Lambrecht

et al.

Mucosal Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

4
From heterogeneity to prognosis: understanding the complexity of tertiary lymphoid structures in tumors DOI
Yingying Wang, Dongyan Zhang, Xueping Huang

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 4, 2025

Language: Английский

Citations

0
Global research prospects and trends in TFH cells and tumors: a bibliometric analysis DOI Creative Commons
Lei Hao, Jin Hu, Junpeng Zhu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 14, 2025

Background T follicular helper (TFH) cells, a subset of CD4 + Th play critical role in B cell activation, proliferation, and differentiation primarily within follicles secondary lymphoid organs, essential processes for effective antibody responses. TFH cells are also implicated various conditions, including autoimmune diseases, cancer, infectious allergies, vaccine reactions. Despite their broad impact, review the literature on tumors has not been conducted. We aimed to fill this gap by providing detailed analysis research landscape concerning tumors. Method conducted bibliometric from 2012 2024 using Web Science Core Collection (WoSCC). For an global landscape, we employed VOSviewer (version 1.6.20), CiteSpace 6.2.R6 software, “bibliometric” package R language 4.3.2) evaluate data countries/regions, authors cited authors, institutions, journals, references, keywords. systematic summarize trends, prospects, hotspots field. Results Our included contributions 60 7,864 35,853 1,756 385 academic 50883 222 keywords, 1,181published papers. Over past decade, volume had consistently increased. China published most papers, more than double that United States. The top 2 ranked publication were Gaulard, Philippe (14 articles, 379 citations), De leval, Laurence (12 236 citations) Notably, 9 10 institutions China. Frontiers Immunology Immunity leading journals publications citations. A cluster revealed shift focus “expression”,”B cells” “survival” “tumor microenvironment”, infiltrating immune “immune infiltration” recent years. Conclusion This suggests hold significant value potential clinical applications tumor immunotherapy. Moreover, offers valuable references guidance related endeavors. It points out prevailing issues challenges research, underscores need further basic advance fields.

Language: Английский

Citations

0