Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4404 - 4404
Published: Dec. 22, 2024
Aim:
This
article
aims
to
explore
the
role
of
human
gut
microbiota
(GM)
in
pathogenesis
neurological,
psychiatric,
and
neurodevelopmental
disorders,
highlighting
its
influence
on
health
disease,
investigating
potential
therapeutic
strategies
targeting
GM
modulation.
Materials
Methods:
A
comprehensive
analysis
microbiota’s
composition
interaction
with
body,
particularly,
neurological
psychiatric
conditions,
is
provided.
The
review
discusses
factors
influencing
composition,
including
birth
mode,
breastfeeding,
diet,
medications,
geography.
Additionally,
it
examines
GM’s
functions,
such
as
nutrient
absorption,
immune
regulation,
pathogen
defense,
alongside
interactions
nervous
system
through
gut–brain
axis,
neurotransmitters,
short-chain
fatty
acids
(SCFAs).
Results:
Alterations
are
linked
various
Parkinson’s
multiple
sclerosis,
depression,
schizophrenia,
ADHD,
autism.
influences
cognitive
stress
responses,
mood
regulation.
Antibiotic
use
disrupts
diversity,
increasing
risk
metabolic
obesity,
allergic
diseases.
Emerging
therapies
probiotics,
prebiotics,
transplantation
show
promise
modulating
alleviating
symptoms
conditions.
Conclusions.
modulation
represents
a
promising
approach
for
personalized
treatment
strategies.
Further
research
needed
better
understand
underlying
mechanisms
develop
targeted
aimed
at
restoring
balance
improved
clinical
outcomes.
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(2)
Published: Jan. 1, 2025
ABSTRACT
The
clinical
application
of
doxorubicin
(DOX)
is
limited
due
to
its
cardiotoxicity,
which
primarily
attributed
interaction
with
iron
in
mitochondria,
leading
lipid
peroxidation
and
myocardial
ferroptosis.
This
study
aimed
investigate
the
role
gut
microbiota‐derived
metabolite,
indole‐3‐lactic
acid
(ILA),
mitigating
DOX‐induced
cardiotoxicity
(DIC).
Cardiac
function,
pathological
changes,
ferroptosis
were
assessed
vivo.
cardioprotective
effects
mechanisms
ILA
explored
using
multi‐omics
approaches,
including
single‐nucleus
RNA
sequencing
(snRNA‐seq)
bulk
RNA‐seq,
further
validated
Nrf2
knockout
mice.
findings
revealed
that
DOX
treatment
disrupted
microbiota,
significantly
reducing
levels
tryptophan
metabolite
ILA.
In
DIC
models,
supplementation
markedly
improved
cardiac
reduced
collagen
deposition,
mitigated
atrophy.
snRNA‐seq
analyses
indicated
played
a
crucial
Experimental
data
demonstrated
decreased
both
mice
DOX‐treated
H9C2
cells,
evidenced
by
restoration
GPX4
SLC7A11
reduction
ACSL4.
Mechanistically,
functions
as
ligand
for
aryl
hydrocarbon
receptor
(AhR),
upregulation
expression.
protective
against
abolished
silencing
AhR.
Moreover,
beneficial
on
eliminated
Nrf2‐deficient
conclusion,
exerts
therapeutic
inhibiting
through
activation
AhR/Nrf2
signalling
pathway.
Identifying
microbial
could
offer
viable
strategies
DIC.
Redox Biology,
Journal Year:
2025,
Volume and Issue:
81, P. 103580 - 103580
Published: March 5, 2025
Despite
the
increasing
recognition
of
interplay
between
depression
and
cardiovascular
disease
(CVD),
precise
mechanisms
by
which
contributes
to
pathogenesis
remain
inadequately
understood.
The
involvement
gut
microbiota
their
metabolites
health
susceptibility
has
been
gaining
attention.
In
this
study,
it
was
found
that
exacerbated
cardiac
injury,
impaired
function
(EF%:
P
<
0.01;
FS%:
0.05),
hindered
long-term
survival
(P
0.01),
intensified
adverse
remodeling
(WGA:
MASSON:
0.0001)
after
myocardial
ischemia/reperfusion
(MI/R)
in
mice.
Then
we
mice
receiving
transplants
from
chronic
social
defeat
stress
(CSDS)
exhibited
worse
0.01)
than
those
non-CSDS
MI/R
injury.
Moreover,
tryptophan
metabolism
due
alterations
composition
structure
observed
CSDS
Mechanistically,
analyzed
metabolomics
fecal
serum
samples
identified
indole-3-propionic
acid
(IPA)
as
a
protective
agent
for
cardiomyocytes
against
ferroptosis
via
NRF2/System
xc-/GPX4
axis,
played
role
mediating
detrimental
influence
on
MI/R.
Our
findings
provide
new
insights
into
IPA
CVD,
forming
basis
intervention
strategies
aimed
at
mitigating
deterioration
following
patients
experiencing
depression.
Journal of Contemporary Medical Practice,
Journal Year:
2025,
Volume and Issue:
7(3), P. 166 - 169
Published: March 28, 2025
Appendectomy,
a
common
procedure
in
general
surgery,
has
traditionally
been
regarded
as
safe
treatment
for
acute
appendicitis.
In
recent
years,
with
the
advancement
of
research
on
microbiota-gut-brain
axis
(MGBA),
increasing
attention
given
to
potential
impact
appendectomy
mental
health,
appendix
plays
crucial
role
intestinal
immunity
and
microbiota
regulation.
This
review
seeks
examine
advancements
relationship
between
disorders,
providing
new
insights
into
clinical
decision-making
process
Critical Reviews in Food Science and Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 23
Published: April 11, 2025
Probiotics
offer
substantial
health
benefits,
leading
to
their
increased
consumption
in
various
food
products.
The
viability
of
probiotics
is
a
critical
factor
that
influences
the
nutritional
and
therapeutic
efficacy
these
foods.
However,
as
often
lose
during
production
oral
administration,
effective
preservation
encapsulation
technologies
are
needed
overcome
this
challenge.
This
review
elucidates
diverse
sources
incorporation
strategies
probiotics,
while
systematically
analyzing
effects
water
transformation
(ice
front
velocity,
glass
transition
temperature,
collapse
temperature),
processing
conditions
(food
matrix,
dissolved
oxygen),
gastrointestinal
challenges
(gastric
fluid,
digestive
enzymes,
bile
salts)
on
probiotic
viability.
Effective
strengthen
encompass
three
primary
domains:
fermentation
processes,
techniques,
methods.
Specifically,
include
meticulous
control
(nitrogen
sources,
lipids,
carbon
sources),
pre-stress
treatments
(pre-cooling,
heat
shock,
NaCl
stress,
acid
stress),
optimized
lyoprotectant
selection
(carbohydrates,
proteins,
polyols),
synergistic
freeze-drying
(infrared
technology,
spray
drying,
microwave),
bulk
approaches
(polysaccharide
or
protein-based
microencapsulation),
single-cell
methods
(self-assembly
surface
functionalization).
Despite
advancements,
targeting
specific
matrices
remains
challenging,
necessitating
further
research
enhance
