Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4404 - 4404
Published: Dec. 22, 2024
Aim:
This
article
aims
to
explore
the
role
of
human
gut
microbiota
(GM)
in
pathogenesis
neurological,
psychiatric,
and
neurodevelopmental
disorders,
highlighting
its
influence
on
health
disease,
investigating
potential
therapeutic
strategies
targeting
GM
modulation.
Materials
Methods:
A
comprehensive
analysis
microbiota’s
composition
interaction
with
body,
particularly,
neurological
psychiatric
conditions,
is
provided.
The
review
discusses
factors
influencing
composition,
including
birth
mode,
breastfeeding,
diet,
medications,
geography.
Additionally,
it
examines
GM’s
functions,
such
as
nutrient
absorption,
immune
regulation,
pathogen
defense,
alongside
interactions
nervous
system
through
gut–brain
axis,
neurotransmitters,
short-chain
fatty
acids
(SCFAs).
Results:
Alterations
are
linked
various
Parkinson’s
multiple
sclerosis,
depression,
schizophrenia,
ADHD,
autism.
influences
cognitive
stress
responses,
mood
regulation.
Antibiotic
use
disrupts
diversity,
increasing
risk
metabolic
obesity,
allergic
diseases.
Emerging
therapies
probiotics,
prebiotics,
transplantation
show
promise
modulating
alleviating
symptoms
conditions.
Conclusions.
modulation
represents
a
promising
approach
for
personalized
treatment
strategies.
Further
research
needed
better
understand
underlying
mechanisms
develop
targeted
aimed
at
restoring
balance
improved
clinical
outcomes.
Biological Research For Nursing,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
Background:
Fatigue
is
a
frequently
reported
symptom
in
children
undergoing
cancer
treatment.
Prior
research
shows
an
inverse
relationship
between
fatigue
and
physical
activity.
Less
known
about
fatigue’s
with
function
or
the
underlying
biological
mechanisms
of
fatigue.
This
study
explored
associations
among
fatigue,
function,
associated
metabolites.
Methods:
Children
(7–18
years)
provided
serum
samples
self-reports
lower
extremity
(mobility)
using
Pediatric
Patient-Reported
Outcomes
Measurement
Information
System
(PROMIS)
surveys
at
two
timepoints
during
therapy.
PROMIS
scores
were
categorized
as
high/low
per
established
cut
points
(high
T
>
47.5;
high
51.5).
High-resolution
liquid
chromatography-mass
spectrometry
extracted
29
metabolites
hypothesized
priori
to
be
function.
Descriptive
statistics
summarized
scores,
linear
mixed
effect
models
estimated
metabolite
adjusting
for
age,
gender
steroid
use.
Results:
Forty
participated
(female,
53%;
7–12
years,
38%;
13–18
years
62%;
Hodgkins
Lymphoma,
33%;
Acute
Lymphoblastic/Lymphocytic
Leukemia,
40%;
Osteosarcoma,
10%;
Other,
17%).
Physical
inversely
related:
T1
(r
=
−0.64;
p
<
.001)
T2
−0.63;
.001).
One
(indole-3-latic
acid)
differentiated
low
Five
significantly
(4-Hydroxybenzoic
acid,
m-Coumaric
myoinositol,
tryptophan,
tyrosine).
Conclusions:
These
findings
substantiate
prior
studies
showing
metabolites,
particularly
amino
acids,
All
significant
gut
microbiome.
was
corelated
providing
another
potential
intervention
management.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4404 - 4404
Published: Dec. 22, 2024
Aim:
This
article
aims
to
explore
the
role
of
human
gut
microbiota
(GM)
in
pathogenesis
neurological,
psychiatric,
and
neurodevelopmental
disorders,
highlighting
its
influence
on
health
disease,
investigating
potential
therapeutic
strategies
targeting
GM
modulation.
Materials
Methods:
A
comprehensive
analysis
microbiota’s
composition
interaction
with
body,
particularly,
neurological
psychiatric
conditions,
is
provided.
The
review
discusses
factors
influencing
composition,
including
birth
mode,
breastfeeding,
diet,
medications,
geography.
Additionally,
it
examines
GM’s
functions,
such
as
nutrient
absorption,
immune
regulation,
pathogen
defense,
alongside
interactions
nervous
system
through
gut–brain
axis,
neurotransmitters,
short-chain
fatty
acids
(SCFAs).
Results:
Alterations
are
linked
various
Parkinson’s
multiple
sclerosis,
depression,
schizophrenia,
ADHD,
autism.
influences
cognitive
stress
responses,
mood
regulation.
Antibiotic
use
disrupts
diversity,
increasing
risk
metabolic
obesity,
allergic
diseases.
Emerging
therapies
probiotics,
prebiotics,
transplantation
show
promise
modulating
alleviating
symptoms
conditions.
Conclusions.
modulation
represents
a
promising
approach
for
personalized
treatment
strategies.
Further
research
needed
better
understand
underlying
mechanisms
develop
targeted
aimed
at
restoring
balance
improved
clinical
outcomes.
