Published: Jan. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 23, 2024
Abstract Diabetic wounds are a major devastating complication of diabetes due to hyperglycemia, bacterial invasion, and persistent inflammation, the current antibiotic treatments can lead emergence multidrug‐resistant bacteria. Herein, bimetallic nanozyme‐based biomimetic bio‐cocklebur (GNR@CeO 2 @GNPs) is designed synthesized for diabetic wound management by depositing spiky ceria (CeO ) shells gold nanoparticles (GNPs) on nanorod (GNR) nanoantenna. The plasmonic‐enhanced nanozyme catalysis self‐cascade reaction properties simultaneously boost two‐step enzyme‐mimicking catalytic activity GNR@CeO @GNPs, leading significant improvement in overall therapeutic efficacy rather than mere additive effects. Under glucose activation 808 nm laser irradiation, @GNPs material captures photons promotes transfer hot electrons from GNR GNPs into CeO , realizing “butterfly effect” consuming local glucose, overcoming limited antibacterial efficiency an individual PTT modality, providing substantial reactive oxygen species. In vitro vivo experiments demonstrate material's exceptional antibiofilm against Gram‐negative Gram‐positive bacteria, which reduce promote collagen deposition, facilitate angiogenesis, thereby accelerating healing. This study provides promising new strategy develop nanozymes with cascade mode antibiotic‐free synergistic treatment infected wounds.
Language: Английский
Citations
14
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216424 - 216424
Published: Jan. 11, 2025
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Abstract In the face of escalating antibiotic resistance crisis, world is embroiled in a silent “antibacterial war”. Scientists are actively searching for innovative antibacterial materials that can be used as effective weapons against bacterial infections. As promising new crystalline porous polymer materials, covalent organic frameworks (COFs) gradually revealing their vast potential applications. This study investigates classification COF‐based agents, provides comprehensive overview applications and research advancements, explores strategies employed by COF materials. Furthermore, challenges outlined lie ahead future application agents insights into prospects within field offered. Through these efforts, aim to accelerate advancements COFs manufacturing technology, promote innovation applications, contribute public health.
Language: Английский
Citations
1
APL Materials, Journal Year: 2025, Volume and Issue: 13(2)
Published: Feb. 1, 2025
Bile duct injuries remain a significant clinical challenge following hepatobiliary surgeries. Recently, 3D-printed tubular scaffolds have shown promise as effective solutions for bile tissue repair. This study presents novel bi-layered scaffold, fabricated using advanced three-dimensional printing technology. The inner layer of this scaffold is constructed from poly(ε-caprolactone) methacrylate (PCLMA), which imparts high mechanical strength. outer composed biocompatible methacrylated recombinant type I collagen (rColMA) and ε-poly(L-lysine)-methacrylamide (EPLMA), providing excellent antibacterial properties. In addition, encapsulated interleukin-6-loaded liposomes (IL-6@Lip) are incorporated into the to further promote regeneration. innovative design creates an optimal microenvironment growth differentiation bone marrow mesenchymal stem cells (BMSCs) duct-like cells. These differentiated contribute regeneration, evidenced by expression key markers, including CK7, CK19, AQP1, AE2, CX43. rColMA/EPLMA/IL-6@Lip hydrogel in significantly enhances BMSC proliferation their epithelial Furthermore, vivo experiments show that PCLMA//rColMA/EPLMA/IL-6@Lip does not induce stasis. novel, pre-differentiated active offers valuable insights regeneration replacement research.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162049 - 162049
Published: April 1, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 13, 2024
This study presents the use of nanoscale covalent organic frameworks (nCOFs) conjugated with tumor-targeting peptides for targeted therapy triple-negative breast cancer (TNBC). While have previously been used delivery, their conjugation COFs represents an innovative approach in this field. In particular, we developed alkyne-functionalized nCOFs chemically modified cyclic RGD (Alkyn-nCOF-cRGD). configuration is designed to specifically target α
Language: Английский
Citations
1
Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)
Published: Nov. 14, 2024
Abstract The increasing prevalence of multidrug-resistant pathogens is a critical public health issue, necessitating the development alternative antibacterial agents. Examples these are methicillin-resistant Staphylococcus aureus (MRSA) and emergence “pan-resistant” Gram-negative strains, such as Pseudomonas aeruginosa Acinetobacter baumannii , which occurred more recently. This review examines various emerging materials with significant activities. Among nanomaterials quantum dots, carbon metal–organic frameworks (MOFs), covalent organic (COFs), layered double hydroxides, all demonstrate excellent properties. Interestingly, including agents within structure can help avoid bacterial resistance improve long-term efficacy materials. Additionally, potential liquid solvents, ionic liquids both deep eutectic solvents natural explored. discusses synthesis methods, advantages, new By providing comprehensive overview innovative materials, this aims to contribute ongoing search for effective solutions combat antibiotic resistance. Key studies demonstrating effects against like Escherichia coli strains summarized. MOFs have exhibited properties through controlled ion release surface interactions. COFs enhanced encapsulated antibiotics displayed intrinsic activity. Other nanomaterials, generated reactive oxygen species, leading microbial inactivation. provide insights into classes highlight them addressing global crisis points • Nanomaterials show strong drug-resistant bacteria Emerging offer novel enhance efficacy, showing promise in combating
Language: Английский
Citations
1
Polymers, Journal Year: 2024, Volume and Issue: 16(23), P. 3244 - 3244
Published: Nov. 22, 2024
Herein, this study reports the development of a multifunctional conductive antibacterial cotton fabric through utilization natural polyphenol-mediated silver mirror reaction. The experimental results demonstrate that polyphenols can effectively facilitate deposition nanoparticles (AgNPs), resulting in uniform and durable hybrid nanocoating on fabric. effects polyphenol's molecular weights coating structures stabilities have been revealed via two distinct approaches: washing resistance electrochemical testing systems. It has concluded lower-molecular-weight phenols induce compact dense structure, whereas such as tannic acid exhibit relatively high stability, achieving an excellent conductivity 0.2 S/cm good 67% over five cycles. underlying mechanism further confirmed by cyclic voltammetry measurements, suggesting play significant role stabilizing AgNPs preventing their dissolution. Furthermore, Ag-doped polyphenol-coated fabrics notable properties. By coupling with typical reactions, not only offers sustainable alternative to synthetic chemicals but also presents promising method endow textiles dual properties activity.
Language: Английский
Citations
1
Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 4, 2024
Comprehensive Summary Regulating brain iron metabolism and reducing neuronal ferroptosis is proven to be a potential method for treating Alzheimer's disease (AD). However, gastric juice has pH of 1.1—2.2 where large number interfering ions are dissociated from the food, which in turn causes traditional oral chelators saturated inactivated. Herein, poly(4‐vinylbenzoic acid) polymer chains were introduced as guided by Fe 3+ ion template into porous network (TpPa‐1) via molecularly imprinted technology obtain chelators, COOH@TpPa‐1. The COOH@TpPa‐1 maintains multiple hydrogen bonding structure block channels stomach (pH ~1.1—2.2) with strongly acidic environment, so just small amount active sites have been occupied. As enters colon, alkaline environment disrupts original hydrogen‐bonded forms anionic fragments, affinity was ~4.0 times that stomach, also gave high selective coefficient 4.2 higher than conventional chelators. These designable "on" "off" states promote effective enrichment within colon chelator produce favorable therapeutic effect on symptoms caused mice.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0