Do endocrine and lipid responses to an ice bath depend on the time of day? DOI Creative Commons

Alexander Braunsperger,

Maximilian Bauer,

Chaima Ben Brahim

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract While the effect of time-of-day (morning versus evening) has been studied in relation to meals and exercise, there are no studies that investigate effects on an ice bath. In this crossover-designed study, we recruited a homogenous group six women men for bath (8–12°C 5 min) morning evening. Venous blood samples were collected before after baths. Both baths increased plasma noradrenaline levels similarly between men. Adrenaline cortisol not affected by any Plasma lipid class composition differs evening only morning, bathing is accompanied significantly higher fatty acid composition. The increase response consistent with concentrations acids. This relationship suggests affects noradrenaline-associated lipolysis induced can be further attributed interindividual responses Apparently, acids via more than

Language: Английский

Cognitive impairment caused by compromised hepatic ketogenesis is prevented by endurance exercise DOI Open Access
Taylor J. Kelty, Nathan R. Kerr, Chien-Chih Chou

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Extensive research has demonstrated endurance exercise to be neuroprotective. Whether these neuroprotective benefits are mediated, in part, by hepatic ketone production remains unclear. To investigate the role of on brain health during exercise, healthy 6‐month‐old female rats underwent viral knockdown rate‐limiting enzyme liver that catalyses first reaction ketogenesis: 3‐hydroxymethylglutaryl‐CoA synthase 2 (HMGCS2). Rats were then subjected either a bout acute or 4 weeks chronic treadmill running (5 days/week) and cognitive behavioural testing. Acute elevated plasma concentration 1 h following exercise. Hepatic HMGCS2 knockdown, verified protein expression, reduced after 48 Proteomic analysis enrichment frontal cortex revealed markers mitochondrial function significantly state 3 complex I + II respiration isolated mitochondria from Spatial memory synaptic plasticity knockdown. These deficiencies prevented training. In summary, data propose ketogenesis is required maintain cognition function, irrespective training status, can overcome neuropathology caused insufficient ketogenesis. results establish mechanistic link between enhance our understanding how peripheral tissue metabolism influences health. image Key points Decades literature demonstrate This study provides set suggest cognition, function. indicate protect against decline compromised prompting further investigation

Language: Английский

Citations

1
Effects of time-of-day on the noradrenaline, adrenaline, cortisol and blood lipidome response to an ice bath DOI Creative Commons

Alexander Braunsperger,

Maximilian Bauer,

Chaima Ben Brahim

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 8, 2025

Abstract While the effect of time-of-day (morning versus evening) on hormones, lipids and lipolysis has been studied in relation to meals exercise, there are no studies that have investigated effects ice bath induced hormone lipidome responses. In this crossover-designed study, a group six women men, 26 ± 5 years old, 176 7 cm tall, weighing 75 10 kg, BMI 23 2 kg/m had an (8–12 °C for min) both morning evening separate days. Absence from intense physical nutrient intake meal order was standardized 24 h prior baths account confounders such as diet or exercise. We collected venous blood samples before after (5 min 30 measure hormones (noradrenaline, adrenaline, cortisol) lipid levels plasma via liquid chromatography mass spectrometry shotgun lipidomics. found increase fatty acids more than evening. Overall composition significantly differed in-between evening, only bathing is accompanied by increased 5.1 2.2% 6.0 2.4% ( P = 0.029) 6.3 3.1% 0.008) after. Noradrenaline not affected immediately 127 2% (pre: 395 158 pg/ml, post min: 896 562 0.025) 144 385 146 937 547 0.015). Cortisol generally higher 179 108 pg/ml 91 59 0.013; 222 96 101 52 0.001; 190 98 54 0.009). There difference hormonal response between men. The main finding study noradrenaline, cortisol responses similar However,

Language: Английский

Citations

0
ExerGeneDB: A physical exercise-regulated differential gene expression database DOI Creative Commons
Ling Pan,

Songwei Ai,

Xiaohui Shi

et al.

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101027 - 101027

Published: Jan. 1, 2025

Exercise induces molecular changes that involve multiple organs and tissues. Moreover, these are modulated by various exercise parameters-such as intensity, frequency, mode, duration-as well clinical features like gender, age, body mass index (BMI), each eliciting distinct biological effects. To assist researchers in understanding from a comprehensive perspective includes organs, diverse regimens, range of features, we developed Regulated Genes Database (ExerGeneDB), database exercise-regulated differential genes. ExerGeneDB aggregated publicly available exercise-related sequencing datasets subjected them to uniform quality control preprocessing. The data, encompassing variety types, were organized into specialized Notably, conducted analyses on this collected leveraging curated information accounting for important factors such BMI. has assembled 1692 samples rats mice 4492 human samples. It contains data tissues skeletal muscle, blood, adipose tissue, intestine, heart, liver, spleen, lungs, kidneys, brain, spinal cord, bone marrow, bones. bulk Ribonucleic acid (RNA-seq) (including non-coding RNA (ncRNA) protein-coding RNA), microarray ncRNA single cell RNA-seq data. compiles re-analyzes with focus information. This culminated the creation an interactive regulation website can be found at: https://exergenedb.com.

Language: Английский

Citations

0
Researcher views on returning results from multi-omics data to research participants: insights from The Molecular Transducers of Physical Activity Consortium (MoTrPAC) Study DOI Creative Commons
Kelly E. Ormond, Caroline Stanclift, Chloe M. Reuter

et al.

BMC Medical Ethics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 7, 2025

Language: Английский

Citations

0
A primer on global molecular responses to exercise in skeletal muscle: Omics in focus DOI Creative Commons
Kevin A. Murach, James R. Bagley

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101029 - 101029

Published: Feb. 1, 2025

Advances in skeletal muscle omics has expanded our understanding of exercise-induced adaptations at the molecular level. Over past 2 decades, transcriptome studies have detailed acute and chronic responses to resistance, endurance, concurrent exercise, focusing on variables such as training status, nutrition, age, sex, metabolic health profile. Multi-omics approaches, integration transcriptomic epigenetic data, along with emerging ribosomal RNA sequencing advancements, further provided insights into how adapts exercise across lifespan. Downstream transcriptome, proteomic phosphoproteomic identified novel regulators adaptations, while single-cell/nucleus spatial technologies promise evolve cellular specialization communication around cells. This narrative review highlights (a) historical foundations muscle, (b) current research 3 layers cascade (DNA, RNA, protein), (c) applications single-cell study adaptation exercise. Further elaboration muscle's global footprint using multi-omics methods will help researchers practitioners develop more effective targeted approaches improve well athletic performance.

Language: Английский

Citations

0
Acute Exercise Rewires the Proteomic Landscape of Human Immune Cells DOI
David Walzik, Niklas Joisten,

Alan J. Metcalfe

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways DOI Creative Commons

Aydan Askarova,

Reuben Mangi Yaa, Sarah J. Marzi

et al.

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(4), P. e1011407 - e1011407

Published: April 9, 2025

Genome-wide association studies have identified thousands of common variants associated with an increased risk neurodegenerative disorders. However, the noncoding localization these has made assignment target genes for brain cell types challenging. Genomic approaches that infer chromosomal 3D architecture can link and distal gene regulatory elements such as enhancers to promoters. By using enhancer-to-promoter interactome maps human microglia, neurons, oligodendrocytes, we cell-type-specific enrichment genetic heritability disorders through stratified linkage disequilibrium score regression. Our analysis suggests multiple is enriched at microglial chromatin contact sites, while schizophrenia predominantly sites in neurons followed by oligodendrocytes. Through Hi-C coupled multimarker genomic annotation (H-MAGMA), disease Alzheimer’s disease, Parkinson’s sclerosis, amyotrophic lateral sclerosis schizophrenia. We found disease-risk were overrepresented microglia compared other across conditions within Notably, pathways largely specific each disease. findings reinforce important, genetically informed type therapeutic interventions highlight potentially targetable disease-relevant pathways.

Language: Английский

Citations

0
Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis DOI Open Access
Jenni Chambers, Clare M. P. Roscoe, Corinna Chidley

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 637 - 637

Published: April 18, 2025

Physical activity (PA) and body composition are important lifestyle factors that influence public health. Research suggests DNA regions (CpG site locations) differentially methylated in a physically active population. This meta-analysis aimed to identify CpG sites associated with various levels of PA metabolic pathways. The followed PRISMA guidelines using PubMed, SportDISCUS, Embase, Scopus, Cochrane Web Science. Epigenomic analyses performed on participants no underlying health conditions were included. Articles screened Rayyan AI extracted sites, their location confirmed the EWAS catalogue. Six studies comprising 770 subjects included this meta-analysis. was clinical metrics from six showed BMI, blood pressure, insulin glucose testing significantly improved upon intervention. Amongst studies, total 257 participants, 134 CpGs located 92 genes obesity-related identified either belonged lipid metabolism or signalling pathway. which regulated multiple tissue types JAZF1 (insulin signalling, carbohydrate pathways) NAV1 (mTOR pathway). In conclusion, current epigenomic induce differential methylation signatures affect metabolism. To understand positive molecular effects PA, further research above candidate needs be conducted amongst

Language: Английский

Citations

0
A multi-epigenomic map of endurance exercise training DOI Creative Commons
Adam P. Sharples

Trends in Genetics, Journal Year: 2024, Volume and Issue: 40(9), P. 736 - 738

Published: July 12, 2024

Language: Английский

Citations

2
Train and Reprogram Your Brain: Effects of Physical Exercise at Different Stages of Life on Brain Functions Saved in Epigenetic Modifications DOI Open Access
Magdalena Kukla-Bartoszek, Katarzyna Głombik

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12043 - 12043

Published: Nov. 9, 2024

Multiple studies have demonstrated the significant effects of physical exercise on brain plasticity, enhancement memory and cognition, mood improvement. Although beneficial impact functions mental health is well established, exact mechanisms underlying this phenomenon are currently under thorough investigation. Several hypotheses emerged suggesting various possible mechanisms, including hormones, neurotrophins, neurotransmitters, more recently also other compounds such as lactate or irisin, which released circumstances act both locally or/and distant tissues, triggering systemic body reactions. Nevertheless, none these actually explain long-lasting effect exercise, can persist for years even be passed to subsequent generations. It believed that mediated through epigenetic modifications, influencing expression particular genes translation modification specific proteins. This review explores regular function plasticity associated occurrence modifications. examines how changes contribute prevention treatment neuropsychiatric neurological disorders, their influence natural aging process health.

Language: Английский

Citations

1