Human Cytomegalovirus in breast milk is associated with milk composition, the infant gut microbiome, and infant growth DOI Creative Commons
Kelsey E. Johnson,

Timothy Heisel,

David A. Fields

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 19, 2023

Abstract Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that often transmitted to the neonate via breast milk. Postnatal CMV transmission can have negative health consequences for preterm and immunocompromised infants, but any effects on healthy term infants are thought be benign. Furthermore, impact of composition hundreds bioactive factors in human milk has not been tested. Here, we utilize cohort exclusively breastfeeding full mother-infant pairs test differences transcriptome metabolome associated with CMV, infant gut microbiome growth. We find upregulation indoleamine 2,3-dioxygenase (IDO) tryptophan-to-kynurenine metabolic pathway CMV+ samples, decreased Bifidobacterium gut. Our data indicate complex relationship between kynurenine, growth; kynurenine positively correlated, viral load negatively weight-for-length at 1 month age. These results suggest transmission, CMV-related changes composition, or both may modulators development.

Language: Английский

Mechanisms of Maternal Diet-Induced Obesity Affecting the Offspring Brain and Development of Affective Disorders DOI Creative Commons
Daniel E. Radford‐Smith, Daniel C. Anthony

Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 455 - 455

Published: March 20, 2023

Depression and metabolic disease are common disorders that share a bidirectional relationship continue to increase in prevalence. Maternal diet maternal behaviour both profoundly influence the developmental trajectory of offspring during perinatal period. At an epidemiological level, depression obesity pregnancy have been shown risk neuropsychiatric subsequent generation. Considerable progress has made understand mechanisms by which disrupts developing gut-brain axis, priming for development affective disorders. This review outlines such detail, including altered care, microbiome, inflammation, breast milk composition, placental metabolites. Subsequently, may be prone interaction with concomitant changes brain energy metabolism, neurotransmission, behaviour, alongside gut dysbiosis. The microbiome act as key modifiable, therefore treatable, feature between function. Further studies examining nutrition, metabolites, neurodevelopment warranted identify novel therapeutic targets.

Language: Английский

Citations

15
Research on Human milk feeding to drive impactful immune health and outcomes in vulnerable preterm infants should evaluate maternal confounders DOI
Christina J. Valentine

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Outcomes in very preterm infants receiving an exclusive human milk diet, or their own mother's milk supplemented with preterm formula DOI Creative Commons
Mohammad Chehrazi, Julia Lanoue, Kayleigh Ougham

et al.

Early Human Development, Journal Year: 2023, Volume and Issue: 187, P. 105880 - 105880

Published: Oct. 21, 2023

An infant's Own Mother's Milk (OMM) is the mainstay of very preterm nutrition. When a supplement required, formula and pasteurised human donor milk (pHDM), are options. Which optimal unknown.

Language: Английский

Citations

10
Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization DOI Creative Commons
Zhi Fang,

Sara A Stickley,

Amirthagowri Ambalavanan

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

3
Importance of human milk for infants in the clinical setting: Updates and mechanistic links DOI Creative Commons
Emily Nagel, Kristin M. Elgersma, Tiffany T. Gallagher

et al.

Nutrition in Clinical Practice, Journal Year: 2023, Volume and Issue: 38(S2)

Published: Sept. 18, 2023

Abstract Introduction Human milk (HM) is the optimal source of nutrition for infants and has been implicated in multiple aspects infant health. Although much existing literature focused on individual components that drive its content, examining HM as a biological system needed meaningful advancement field. Investigation nonnutritive bioactive maternal, infant, environmental factors which affect these bioactives important to better understand importance provision infants. This information may inform care clinical populations or who are critically ill, hospitalized, have chronic diseases benefit most from receiving HM. Methods In this narrative review, we reviewed maternal influences composition with focus studies published last 10 years were applicable populations. Results We found immune gut health neurodevelopment. Additional work how donor formula be used situations inadequate Furthermore, understanding such genetics metabolic influence needed. Conclusion affirm all infants, especially An modulated by progress field forward respect mechanistic links between biology outcomes.

Language: Английский

Citations

7
The Influence of Maternal Lifestyle Factors on Human Breast Milk Microbial Composition: A Narrative Review DOI Creative Commons

Irene Bianco,

Chiara Ferrara, Francesca Romano

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2423 - 2423

Published: Oct. 22, 2024

Human breast milk (HBM) is considered the gold standard for infant nutrition due to its optimal nutrient profile and complex composition of cellular non-cellular components. Breastfeeding positively influences newborn's gut microbiota health, reducing risk conditions like gastrointestinal infections chronic diseases (e.g., allergies, asthma, diabetes, obesity). Research has revealed that HBM contains beneficial microbes aid maturation through mechanisms antimicrobial production pathogen exclusion. The can be affected by several factors, including gestational age, delivery mode, medical treatments, lactation stage, as well maternal lifestyle habits diet, physical activity, sleep quality, smoking, alcohol consumption, stress level). Particularly, factors play a significant role in shaping directly modulating microbial or influencing enteromammary pathway. This narrative review current findings summarized how microbiota. While influence diet on well-documented, indicating dietary patterns, especially those rich plant-based proteins carbohydrates, microbiota, impact other poorly investigated. Maintaining healthy during pregnancy breastfeeding crucial health both mother baby. Understanding colonization HBM, along with their interactions impact, key developing new strategies support infant's

Language: Английский

Citations

2
Unlocking the genetic influence on milk variation and its potential implication for infant health DOI Creative Commons

Claudia Nussbaum,

Sarah Kim-Hellmuth

Cell Genomics, Journal Year: 2024, Volume and Issue: 4(10), P. 100676 - 100676

Published: Oct. 1, 2024

Human milk has long been recognized for its critical role in infant and maternal health. In this issue of Cell Genomics, Johnson et al.1 apply a human genetics genomics approach to shed light on the complex relationship between genetics, variation, gut microbiome.

Language: Английский

Citations

0
Maternal Milk Orchestrates the Development of Infant Gut Microbiota: Implications for Health and Future Research Directions DOI Creative Commons
Ran Wang,

Siyuan Sun,

Qi Zhang

et al.

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 10, 2024

Human breast milk serves as a vital source of nutrition for infants, and it also plays critical role in shaping the infant gut microbiota establishing intestinal homeostasis. This process substantially impacts immune function, neurodevelopment, overall health. The noninvasive nature collection makes an ethical accessible area research, positioning key focus future studies. These directions include identification novel bacteria combination, establishment comprehensive databases on microbiota, use computational models to predict interactions between components microbiome. Additionally, creation diverse biological stool banks will further enhance understanding host–microbiome support disease prevention strategies.

Language: Английский

Citations

0
Human Cytomegalovirus in breast milk is associated with milk composition, the infant gut microbiome, and infant growth DOI Creative Commons
Kelsey E. Johnson,

Timothy Heisel,

David A. Fields

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 19, 2023

Abstract Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that often transmitted to the neonate via breast milk. Postnatal CMV transmission can have negative health consequences for preterm and immunocompromised infants, but any effects on healthy term infants are thought be benign. Furthermore, impact of composition hundreds bioactive factors in human milk has not been tested. Here, we utilize cohort exclusively breastfeeding full mother-infant pairs test differences transcriptome metabolome associated with CMV, infant gut microbiome growth. We find upregulation indoleamine 2,3-dioxygenase (IDO) tryptophan-to-kynurenine metabolic pathway CMV+ samples, decreased Bifidobacterium gut. Our data indicate complex relationship between kynurenine, growth; kynurenine positively correlated, viral load negatively weight-for-length at 1 month age. These results suggest transmission, CMV-related changes composition, or both may modulators development.

Language: Английский

Citations

0