Drug repositioning in the AI-driven era: data, approaches, and challenges DOI
Jing Wang,

Siming Kong,

Xiaochen Bo

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

The advent of artificial intelligence (AI) has revolutionized drug repositioning, transforming it into an indispensable strategy for accelerating discovery. This chapter offers in-depth exploration the multifaceted landscape repositioning in AI era, emphasizing profound influence on this domain and providing a roadmap future research. Beginning with brief summary data that form bedrock field, biomedical databases encompassing drugs, diseases, molecular targets, clinical are introduced detail. Then experimental computational approaches underpin further dissected, ranging from binding assays or phenotypic screening to multi-omics methodologies silico technologies, emphasis AI-driven methods. Subsequently, successful cases across diverse diseases highlighted. Finally, importance fully leveraging address challenges is underscored.

Language: Английский

3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair DOI Creative Commons
Tao Zhang, Shihao Sheng,

Weihuang Cai

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 257 - 269

Published: Sept. 4, 2024

Language: Английский

Citations

8
Organoids in Haematologic Research: Advances and Future Directions DOI Creative Commons
Liangzheng Chang, Lu Li, Yuling Han

et al.

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

ABSTRACT Organoid technology, as a revolutionary biomedical tool, has shown immense potential in haematological research recent years. By using three‐dimensional (3D) cell culture systems constructed from pluripotent stem cells (PSCs) or adult (ASCs), organoids can highly mimic the characteristics of vivo organs, thereby offering significant for investigating human organ development, disease processes and treatment strategies. This review introduces development focuses on their progress research, including haematopoietic‐related organoids, immune‐related used studying blood system diseases. It discusses prospects, challenges future outlook field haematology. aims to provide latest advancements directions organoid technology references insights into further exploration this field.

Language: Английский

Citations

1
Patient‐derived ovarian cancer organoid carries immune microenvironment and blood vessel keeping high response to cisplatin DOI Creative Commons
Yuqing Zhao, Chen Wang, Wei Deng

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(9)

Published: Aug. 28, 2024

Ovarian cancer is high recurrence and mortality malignant tumor. The most common ovarian was High-Grade Serous Cancer. However, Cancer organoid rare, which with patient immune microenvironment blood vessels even absence. Here, we report a novel system derived from samples. These organoids recapitulate organoids' histological molecular heterogeneity while preserving the critical vessels, as evidenced by presence of

Language: Английский

Citations

5
Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues DOI Creative Commons
Claudia Tanja Mierke

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1638 - 1638

Published: Oct. 1, 2024

The 3D bioprinting technique has made enormous progress in tissue engineering, regenerative medicine and research into diseases such as cancer. Apart from individual cells, a collection of organoids, can be printed combination with various hydrogels. It hypothesized that will even become promising tool for mechanobiological analyses organoids their matrix environments highly defined precisely structured environments, which the mechanical properties cell environment individually adjusted. Mechanical obstacles or bead markers integrated bioprinted samples to analyze deformations forces within these constructs, perform biophysical analysis complex systems, are still not standard techniques. review highlights advances 4D printing technologies integrating cues so next step detailed key future directions organoid generation development disease model regeneration drug testing perspective. Finally, hydrogels, pure natural synthetic hydrogels mixtures, organoid–cell co-cultures, organ-on-a-chip systems organoid-organ-on-a chip combinations introduces use assembloids determine mutual interactions different types cell–matrix interferences specific biological environments.

Language: Английский

Citations

5
Artificial intelligence for life sciences: A comprehensive guide and future trends DOI

Ming Luo,

Wenyu Yang, Long Bai

et al.

The Innovation Life, Journal Year: 2024, Volume and Issue: unknown, P. 100105 - 100105

Published: Jan. 1, 2024

<p>Artificial intelligence has had a profound impact on life sciences. This review discusses the application, challenges, and future development directions of artificial in various branches sciences, including zoology, plant science, microbiology, biochemistry, molecular biology, cell developmental genetics, neuroscience, psychology, pharmacology, clinical medicine, biomaterials, ecology, environmental science. It elaborates important roles aspects such as behavior monitoring, population dynamic prediction, microorganism identification, disease detection. At same time, it points out challenges faced by application data quality, black-box problems, ethical concerns. The are prospected from technological innovation interdisciplinary cooperation. integration Bio-Technologies (BT) Information-Technologies (IT) will transform biomedical research into AI for Science paradigm.</p>

Language: Английский

Citations

5
Airway Basal Stem Cells Inflammatory Alterations in COVID‐19 and Mitigation by Mesenchymal Stem Cells DOI Creative Commons
Shuyan Du, Jing Jin, Chunli Tang

et al.

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

SARS-CoV-2 infection and the resultant COVID-19 pneumonia cause significant damage to airway lung epithelium. This manifests as mucus hypersecretion, pulmonary inflammation fibrosis, which often lead long-term complications collectively referred long COVID or post-acute sequelae of (PASC). The epithelium, first line defence against respiratory pathogens, depends on basal stem cells (BSCs) for regeneration. Alterations in BSCs are associated with impaired epithelial repair may contribute observed PASC. Given critical role maintaining integrity, understanding their alterations is essential developing effective therapeutic strategies. study investigates intrinsic properties derived from patients evaluates modulatory effects mesenchymal (MSCs). Through a combination functional assessments transcriptomic profiling, we identified key phenotypic molecular deviations patient-derived BSCs, including goblet cell hyperplasia, underlie contribution Notably, MSC co-culture significantly mitigated these adverse effects, potentially through modulation interferon signalling pathway. isolate Chinese population establish BSC-based xenograft model. Our findings reveal insights into inflammatory pathology, potential relevance PASC virus-induced sequelae. Additionally, our highlights MSC-based therapies promising strategy address persistent symptoms.

Language: Английский

Citations

0
Comprehensive pan-cancer analysis reveals CD70 as a promising therapeutic target and biomarker in clear cell renal cell carcinoma DOI
Xuezhou Zhang, Baoan Hong, Wei Yu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142079 - 142079

Published: March 1, 2025

Language: Английский

Citations

0
Recent advancement in prevention against hepatotoxicity, molecular mechanisms, and bioavailability of gallic acid, a natural phenolic compound: challenges and perspectives DOI Creative Commons
Peng Chen, Fan Zou, Wei Liu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Drug-induced liver injury (DILI) results from the toxicity caused by drugs or their metabolites. Gallic acid (GA) is a naturally occurring secondary metabolite found in many fruits, plants, and nuts. Recently, GA has drawn increasing attention due to its potent pharmacological properties, particularly anti-inflammatory antioxidant capabilities. To best of our knowledge, this first review focus on properties related molecular activation mechanisms regarding protection against hepatotoxicity. We also provide thorough explanation physicochemical fruit sources, toxicity, pharmacokinetics after reviewing substantial number studies. Pharmacokinetic studies have shown that quickly absorbed eliminated when taken orally, which restricts use development. However, bioavailability can be increased optimizing structure changing form administration. Notably, according toxicology conducted range animals clinical trials, rarely exhibits side effects. The antioxidation mainly involved Nrf2, while MAPKs NF-κB signaling pathways. Owing marked prospective candidate for management diverse xenobiotic-induced discuss applications cutting-edge technologies (nano-delivery systems, network pharmacology, organoids) DILI. In addition guiding future research development as medicine, study offers theoretical foundation application.

Language: Английский

Citations

0
Organoid development and applications in gynecological cancers: the new stage of tumor treatment DOI Creative Commons
Yang Li, Meiying Qin, Ning Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 16, 2025

Gynecologic cancers (GCs), including cervical cancer (CC), ovarian (OC), endometrial (EC), as well vulvar and vaginal cancers, represent major health threats to women, with increasing incidence rates observed globally. Conventional treatments, such surgery, radiation therapy, chemotherapy, are often hindered by challenges drug resistance recurrence, contributing high mortality rates. Organoid technology has emerged a transformative tool in research, offering vitro models that closely replicate the tumor cell architecture heterogeneity of primary cancers. Tumor-derived organoids preserve histological molecular characteristics original tumors, making them invaluable for studying biology, pathways, immune microenvironment. Furthermore, play crucial role biomarker discovery, screening, development personalized therapeutic strategies. In contrast traditional lines patient-derived xenograft (PDX) models, gynecologic accurately mirror genetic mutations specific gene expression profiles tumors. This review provides an overview recent advancements organoid highlighting their contributions understanding disease mechanisms, facilitating advancing precision medicine. It also addresses potential technology, focus on its treatment approaches GCs.

Language: Английский

Citations

0
Tumor organoids in cancer medicine: from model systems to natural compound screening DOI Creative Commons
Rong Cong, Can Lu, Xinying Li

et al.

Pharmaceutical Biology, Journal Year: 2025, Volume and Issue: 63(1), P. 89 - 109

Published: Feb. 1, 2025

The advent of tissue engineering and biomedical techniques has significantly advanced the development three-dimensional (3D) cell culture systems, particularly tumor organoids. These self-assembled 3D clusters closely replicate histopathological, genetic, phenotypic characteristics primary tissues, making them invaluable tools in cancer research drug screening. This review addresses challenges developing vitro models that accurately reflect heterogeneity explores application organoids research, with a specific focus on screening natural products for antitumor therapies. synthesizes information from major databases, including Chemical Abstracts, Medicinal Aromatic Plants ScienceDirect, Google Scholar, Scopus, PubMed Springer Link. Publications were selected without date restrictions, using terms such as 'organoid', 'natural product', 'pharmacological', 'extract', 'nanomaterial' 'traditional uses'. Articles related to agriculture, ecology, synthetic work or published languages other than English excluded. identifies key efficiency variability organoid generation discusses ongoing efforts enhance their predictive capabilities personalized medicine. Recent studies utilizing patient-derived compound are highlighted, demonstrating potential these new classes anticancer agents. integration presents promising approach discovering novel compounds elucidating mechanisms action.

Language: Английский

Citations

0