Population Pharmacokinetics of Vancomycin in Intensive Care Patients with the Time-Varying Status of Temporary Mechanical Circulatory Support or Continuous Renal Replacement Therapy DOI Creative Commons
Meng‐Ta Tsai, Wei Wang, Jun‐Neng Roan

et al.

Infectious Diseases and Therapy, Journal Year: 2024, Volume and Issue: 13(12), P. 2617 - 2635

Published: Nov. 14, 2024

This study characterized the population pharmacokinetics (PK) of vancomycin in patients treated with and without continuous renal replacement therapy (CRRT) or temporary mechanical circulatory support (tMCS), including extracorporeal membrane oxygenation ventricular assist device. Critically ill adults tMCS CRRT prescribed were enrolled for PK modeling. Monte Carlo simulation provided dosing recommendations based on probability target attainment (PTA), achieving a 24-h area under curve (AUC24h) 400–600 mg*h/L. Twenty-five 184 plasma samples analyzed. The median age was 61.0 years. final model two-compartment model. CRRT, serum creatinine, body weight significant predictors clearance. covariate central volume distribution. significantly decreased intercompartmental simulated mean trough levels at 48th hour lower group (13.4 versus 14.2 mg/dL non-tMCS, p < 0.001) 70-kg subject creatinine 1 daily dose 20 mg/kg, but PTA similar (61.8% 62.2%). A reduction maintenance from 30 to 10 mg/kg/day loading 25 15 mg/kg is recommended while progresses 0.5 4.0 mg/dL. For optimal regimen consists 20–25 mg/kg/day. strategy can be function, regardless tMCS. Intercompartmental clearance decreases tMCS, which mislead adjustment level.

Language: Английский

Population Pharmacokinetics of Vancomycin in Intensive Care Patients with the Time-Varying Status of Temporary Mechanical Circulatory Support or Continuous Renal Replacement Therapy DOI Creative Commons
Meng‐Ta Tsai, Wei Wang, Jun‐Neng Roan

et al.

Infectious Diseases and Therapy, Journal Year: 2024, Volume and Issue: 13(12), P. 2617 - 2635

Published: Nov. 14, 2024

This study characterized the population pharmacokinetics (PK) of vancomycin in patients treated with and without continuous renal replacement therapy (CRRT) or temporary mechanical circulatory support (tMCS), including extracorporeal membrane oxygenation ventricular assist device. Critically ill adults tMCS CRRT prescribed were enrolled for PK modeling. Monte Carlo simulation provided dosing recommendations based on probability target attainment (PTA), achieving a 24-h area under curve (AUC24h) 400–600 mg*h/L. Twenty-five 184 plasma samples analyzed. The median age was 61.0 years. final model two-compartment model. CRRT, serum creatinine, body weight significant predictors clearance. covariate central volume distribution. significantly decreased intercompartmental simulated mean trough levels at 48th hour lower group (13.4 versus 14.2 mg/dL non-tMCS, p < 0.001) 70-kg subject creatinine 1 daily dose 20 mg/kg, but PTA similar (61.8% 62.2%). A reduction maintenance from 30 to 10 mg/kg/day loading 25 15 mg/kg is recommended while progresses 0.5 4.0 mg/dL. For optimal regimen consists 20–25 mg/kg/day. strategy can be function, regardless tMCS. Intercompartmental clearance decreases tMCS, which mislead adjustment level.

Language: Английский

Citations

1