Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 656 - 656

Published: Nov. 25, 2024

Background/Objective: A dysregulated metabolism has been studied as a key aspect of the COVID-19 pathophysiology, but its longitudinal progression in severe cases remains unclear. In this study, we aimed to investigate metabolic dysregulation over time patients with requiring mechanical ventilation (MV). Methods: single-center, prospective, observational obtained 236 serum samples from 118 adult on MV an ICU. The metabolite measurements were performed using capillary electrophoresis Fourier transform mass spectrometry, and categorized sampling points into three zones align them disease progression: zone 1 (T1) (the hyperacute phase, days 1–3 post-MV initiation), T2 acute 4–14), T3 chronic 15–30). Using volcano plots enrichment pathway analyses, identified differential metabolites (DMs) enriched pathways (EPs) between survivors non-survivors for each zone. DMs EPs further grouped early-stage, late-stage, consistent groups based which they detected. Results: With 566 annotated metabolites, 38 17 early-stage group, indicated enhanced energy production glucose, amino acid, fatty acid metabolisms non-survivors. As late-stage 84 10 showed upregulated sphingolipid, taurine, tryptophan–kynurenine downregulated steroid hormone synthesis Three 23 group more pronounced dopamine arachidonic across all Conclusions: This study elucidated temporal differences COVID-19, offering insights mechanisms.

Language: Английский